Patents Assigned to Lung Biotechnology Inc.
  • Patent number: 10258570
    Abstract: The invention relates to liposomes for pulmonary application, advantageously comprising at least one first and at least one second phospholipid, cholesterol, and at least one active substance and/or colorant, wherein the first phospholipid is a phosphatidylcholine, preferably DSPC, and the second phospholipid is a phosphatidylcholine or an ethanolamine, preferably selected from the group DMPC, DPPC, DPPE. It is thereby advantageous if the first and the second phospholipid are present at a molar ratio of 0.5:1 to 10:1, preferably at a ratio of 6:1 to 2:1, in particular preferably at a ratio of 3:1. It is further advantageous if the molar ratio between phospholipids and cholesterol is between 10:1 and 1:1, preferably between 6:1 and 3:1, in particular preferably 4:1. The second phospholipid is further preferably DMPC or DPPE, in particular preferably DPPE. The size of the liposomes is advantageously between 0.05 ?m and 5 ?m, preferably between 0.2 ?m and 2.
    Type: Grant
    Filed: June 29, 2010
    Date of Patent: April 16, 2019
    Assignee: Lung Biotechnology Inc.
    Inventors: Tobias Gessler, Thomas Schmehl, Monika Rieger
  • Publication number: 20150183757
    Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Application
    Filed: March 12, 2015
    Publication date: July 2, 2015
    Applicant: Lung Biotechnology Inc.
    Inventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar
  • Publication number: 20150025255
    Abstract: The presently disclosed subject matter provides methods of preparing synthetic prostacyclin analogues, including Beraprost, either as racemic mixtures or as single stereoisomers. Also provided are novel synthetic intermediates for use in these methods.
    Type: Application
    Filed: September 12, 2012
    Publication date: January 22, 2015
    Applicant: Lung Biotechnology Inc.
    Inventors: George Petros Yiannikouros, Panos Kalaritis, Chaminda Priyapushpa Gamage, Denis Viktorovich Arefyev
  • Publication number: 20140275573
    Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Application
    Filed: June 3, 2014
    Publication date: September 18, 2014
    Applicant: LUNG BIOTECHNOLOGY INC.
    Inventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar
  • Patent number: 8779170
    Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: July 15, 2014
    Assignee: Lung Biotechnology Inc.
    Inventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar