Patents Assigned to Lung Biotechnology PBC
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Publication number: 20200040306Abstract: A printable composition for the manufacture of cell-receiving scaffolds comprising about 0.3 wt % to about 3.0 wt % of one or more collagens; about 5.0 wt % to about 40.0 wt % of one or more monomers; about 0.5 wt % to about 2.0 wt % of a photo initiator; and 0 wt % to about 75 wt % of a vehicle comprising a protic solvent, by weight of the printable composition; wherein the printable composition has a resolution of about 100 microns or less when printed, a photo speed (Dp/Ec) of about 0.1-5 mm (Dp) and about 10-100 mJ/cm2 (Ec) when printed, and a green strength of at least about 5 kPa after drying. The present technology further includes methods of manufacturing a three-dimensional cell-receiving scaffold using the printable composition.Type: ApplicationFiled: August 1, 2019Publication date: February 6, 2020Applicant: Lung Biotechnology PBCInventors: Pingyong Xu, Luis Alvarez, Derek Morris, Iman Yazdi
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Publication number: 20190202797Abstract: The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost.Type: ApplicationFiled: March 11, 2019Publication date: July 4, 2019Applicant: Lung Biotechnology PBCInventors: Hitesh Batra, Sudersan M. Tuladhar, Sri Harsha Tummala, Raju Penmasta, David A. Walsh
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Publication number: 20190194156Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.Type: ApplicationFiled: March 1, 2019Publication date: June 27, 2019Applicant: Lung Biotechnology PBCInventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar
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Patent number: 10266509Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analog compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.Type: GrantFiled: April 24, 2018Date of Patent: April 23, 2019Assignee: Lung Biotechnology PBCInventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar
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Patent number: 10246430Abstract: The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost.Type: GrantFiled: May 4, 2018Date of Patent: April 2, 2019Assignee: Lung Biotechnology PBCInventors: Hitesh Batra, Sudersan M. Tuladhar, Sri Harsha Tummala, Raju Penmasta, David A. Walsh
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Publication number: 20180265490Abstract: The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost.Type: ApplicationFiled: May 4, 2018Publication date: September 20, 2018Applicant: Lung Biotechnology PBCInventors: Hitesh Batra, Sudersan M. Tuladhar, Sri Tummala, Raju Penmasta, David A. Walsh
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Publication number: 20180237408Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.Type: ApplicationFiled: April 24, 2018Publication date: August 23, 2018Applicant: Lung Biotechnology PBCInventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar
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Patent number: 10005753Abstract: The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost. In one aspect, a process is provided to produce a pharmaceutical compound represented by the general Formula (I) via a radical cyclization route. The process is completed in fewer steps than the known synthetic methods and may be conducted to prepare commercially useful quantities. In another aspect, synthetic methods are provided for producing Beraprost and its derivatives, which are stereoselective, efficient, scalable and economical. In another aspect, substantially isomerically pure compounds and intermediates are produced by the above processes.Type: GrantFiled: May 19, 2015Date of Patent: June 26, 2018Assignee: Lung Biotechnology PBCInventors: Hitesh Batra, Sudersan M. Tuladhar, Sri Harsha Tummala, Raju Penmasta, David A. Walsh
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Patent number: 9969706Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analog compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.Type: GrantFiled: February 23, 2017Date of Patent: May 15, 2018Assignee: Lung Biotechnology PBCInventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar
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Publication number: 20170166545Abstract: The present invention is directed to methods for preparing Beraprost and novel synthetic intermediates for Beraprost. In one aspect, a process is provided to produce a pharmaceutical compound represented by the general Formula (I) via a radical cyclization route. The process is completed in fewer steps than the known synthetic methods and may be conducted to prepare commercially useful quantities. In another aspect, synthetic methods are provided for producing Beraprost and its derivatives, which are stereoselective, efficient, scalable and economical. In another aspect, substantially isomerically pure compounds and intermediates are produced by the above processes.Type: ApplicationFiled: May 19, 2015Publication date: June 15, 2017Applicant: Lung Biotechnology PBCInventors: Hitesh Batra, Sudersan M. Tuladhar, Sri Harsha Tummala, Raju Penmasta, David A. Walsh
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Publication number: 20170158658Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.Type: ApplicationFiled: February 23, 2017Publication date: June 8, 2017Applicant: Lung Biotechnology PBCInventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar
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Patent number: 9611243Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.Type: GrantFiled: April 8, 2016Date of Patent: April 4, 2017Assignee: Lung Biotechnology PBCInventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar
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Patent number: 9579442Abstract: An array of hollow fibers including a plurality of hollow fibers of a predetermined diameter configured to receive a gas having oxygen therein and transfer the oxygen to a fluid and/or transfer carbon dioxide in the fluid to a gas. The array is configured in a predetermined pattern having a predetermined packing density that is a fraction of a total cross-sectional area of the array occupied by the hollow fibers.Type: GrantFiled: January 5, 2015Date of Patent: February 28, 2017Assignee: Lung Biotechnology PBCInventors: Anna M. Galea, Kristen LeRoy, Nicholas Vitale
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Publication number: 20160244422Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.Type: ApplicationFiled: April 8, 2016Publication date: August 25, 2016Applicant: Lung Biotechnology PBCInventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar
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Patent number: 9334255Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.Type: GrantFiled: March 12, 2015Date of Patent: May 10, 2016Assignee: Lung Biotechnology PBCInventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar
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Patent number: 9181212Abstract: An improved method is described for making single isomers of synthetic benzoprostacyclin analog compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds.Type: GrantFiled: June 3, 2014Date of Patent: November 10, 2015Assignee: Lung Biotechnology PBCInventors: Vijay Sharma, Hitesh Batra, Sudersan Tuladhar