Abstract: The present disclosure provides biomarkers associated with caveolin-1 peptide therapy in subjects with interstitial lung disease. In particular, the present disclosure describes biomarkers such as MYDGF, soluble RAGE, pSMAD2/3, and PDGFR? associated with caveolin-1 peptide therapy in subjects with idiopathic pulmonary fibrosis. These biomarkers could be used to determine efficacy, monitoring, and optimal dosing of caveolin-1 peptide therapy in subjects with interstitial lung disease.
Abstract: Provided herein are compositions comprising caveolin-1 (Cav-1) peptides. Further provided are methods of using the Cav-1 peptides for the treatment of lung infections or acute or chronic lung injury, particularly lung fibrosis.
Type:
Application
Filed:
February 6, 2024
Publication date:
August 15, 2024
Applicants:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, LUNG THERAPEUTICS, LLC
Inventors:
Robert O. WILLIAMS, III, Alan B. WATTS, Yajie ZHANG, Sawittree SAHAKIJPIJARN, Dale CHRISTENSEN, John J. KOLENG