Patents Assigned to Lupin Ltd.
-
Patent number: 9931405Abstract: A novel pharmaceutical composition, which comprises a therapeutically effective amount of active principle(s) or a pharmaceutically acceptable salt or enantiomer or polymorph thereof, optionally one or more release controlling agent(s) and pharmaceutical acceptable excipient(s) thereof, wherein the composition is formulated to increase the residence time of the said pharmaceutical composition and/or active principle(s) in the gastrointestinal tract. A novel pharmaceutical composition comprising at least two entities wherein one entity is an immediate release/fast release and the other is controlled release. A pharmaceutical composition comprising at least two entities wherein one entity is an immediate release/fast release and the other is bioadhesive. A pharmaceutical composition comprising: at least two entities wherein one entity is controlled release and the other is bioadhesive All the three compositions are formulated to increase the residence time of active principle(s) in the gastrointestinal tract.Type: GrantFiled: February 2, 2015Date of Patent: April 3, 2018Assignee: LUPIN LTD.Inventors: Harshal Anil Jahagirdar, Rajesh Kulkarni, Shirishkumar Kulkarni
-
Patent number: 9149482Abstract: A chewable tablet comprising Cefixime having a mean particle size between 20? and 120? wherein the said composition demonstrates bioequivalence to a suspension of Cefixime trihydrate. The process of preparation of the chewable tablet comprises the steps of optionally micronizing Cefixime such that the mean particle size of the Cefixime particles is between 20? and 120?, blending with other excipients, roll compaction, milling to form granules, blending to form a secondary blend and compression of the secondary blend to form tablets.Type: GrantFiled: May 10, 2004Date of Patent: October 6, 2015Assignee: Lupin Ltd.Inventors: Sanjay Wagh, Hidaytulla Aga, Makarand Avachat, Himadri Sen
-
Publication number: 20140171401Abstract: A chewable tablet comprising Cefixime having a mean particle size between 20? and 120? wherein the said composition demonstrates bioequivalence to a suspension of Cefixime trihydrate. The process of preparation of the chewable tablet comprises the steps of optionally micronizing Cefixime such that the mean particle size of the Cefixime particles is between 20? and 120?, blending with other excipients, roll compaction, milling to form granules, blending to form a secondary blend and compression of the secondary blend to form tablets.Type: ApplicationFiled: February 24, 2014Publication date: June 19, 2014Applicant: LUPIN LTD.Inventors: Sanjay WAGH, Hidaytulla AGA, Makarand AVACHAT, Himadri SEN
-
Patent number: 8269023Abstract: An improved process for synthesis of duloxetine hydrochloride (1) having chiral purity greater than 99.9% that is characterized by the following: (i) preparation of racemic condensed compound (RS)—N,N-di methyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine (4) by reaction of racemic hydroxy compound (2) with 1-fluoronaphthalene (3) in presence of a base such as sodamide, potassium amide or potassium bis(trimethylsilyl)amide (KHDMS) in polar aprotic solvent, (ii) optical resolution of racemic condensed compound (5a+5b) with di-benzoyl-L-tartaric acid (7, DBTA, R=H) or di-para-anisoyl-L-tartaric acid (7, DATA, R=OCH3) to obtain crude (S)—N.N-dimethyl-3-(1-naphthyloxy)-3-(2-thienyl)propanamine dibenzoyl tartarate salt (8a) or (S)—N.Type: GrantFiled: March 5, 2008Date of Patent: September 18, 2012Assignee: Lupin Ltd.Inventors: Rajinder Singh Siyan, Sunil Kumar Vinubhai Gohel, Girij Pal Singh
-
Patent number: 7777056Abstract: A process for preparation of 4-hydroxy-pyran-2-one derivative of formula (I), wherein R is, and wherein R1 and R2 are methyl and R3 is hydrogen or methyl, comprising the steps of, heating a compound of formula (II), wherein R is as defined before, and R4 is hydrogen, NH4+ or an alkali metal, in a solvent mixture consisting of an aromatic hydrocarbon and a ketone in an inert atmosphere at a temperature of between 60° C. to 92° C. in the absence or presence of orthophosphoric acid or its alkali dihydrogen salts or alkali hydrogen salts of a dibasic acid, followed by optional neutralization of the reaction mixture with an organic base and obtaining compound of formula (I) in high purity and substantially free of impurities through a step of isolation and crystallization. The process leads to formation of derivatives of formula I in high purity with dimmer impurity (III) less than 0.1% and anhydro impurity (IV) below 0.15%.Type: GrantFiled: March 30, 2004Date of Patent: August 17, 2010Assignee: Lupin Ltd.Inventors: Milind Moreshwar Gharpure, Swapnil Panditrao Sonawane, Srihari Shivaji Mane, Rajendra Dagesing Mahale
-
Publication number: 20090028940Abstract: A pharmaceutical composition comprising therapeutically effective amount of rifaximin or pharmaceutically acceptable salt or enantiomer or polymorph thereof, pharmaceutically acceptable excipient(s) and release controlling agent(s). Pharmaceutical composition of rifaximin comprising: at least two entities wherein one entity is an immediate release or fast release and the other is controlled release. The pharmaceutical composition in the form of multilayer tablet comprising, at least one layer comprising, therapeutically effective amount of rifaximin or pharmaceutically acceptable salt or enantiomer or polymorph thereof, pharmaceutically acceptable excipient(s); said layer providing controlled release rifaximin; and at least one layer which provides increased residence time of the dosage form in the gastrointestinal tract. The pharmaceutical formulation comprising rifaximin having an in vitro dissolution profile, wherein about 70% of rifaximin is released in about 24 hours.Type: ApplicationFiled: June 23, 2008Publication date: January 29, 2009Applicant: LUPIN LTD.Inventors: Harshal Anil Jahagirdar, Rajesh Kulkarni, Shirishkumar Kulkarni
-
Publication number: 20090022809Abstract: A stable taste masked, pharmaceutical composition comprising a plurality of coated, non-disintegrating discrete dosage units, said units comprising of a core comprising one or more cephalosporins such as cefuroxime axetil and cefpodoxime proxetil and one or more coating layers. Cefuroxime axetil is in ?-crystalline and amorphous forms, where at least 30% of the Cefuroxime axetil is in the ?-crystalline form, wherein the particle size distribution of the ?-crystalline form being such that 100% of the particles have a particle size below 250?. The ratio of the crystalline fraction to the amorphous fraction ranges from 0.3:0.7 to 0.99:0.01. The particle size of cefpodoxime proxetil is such that 90% of the particles are below 15?.Type: ApplicationFiled: December 2, 2005Publication date: January 22, 2009Applicant: LUPIN LTD.Inventors: Sachin Pundlik Kolhe, Subrata Kundu, Sanjay Chhagan Wagh, Makarand Krishnakumar Avachat, Himadri Sen
-
Publication number: 20090011019Abstract: A novel pharmaceutical composition, which comprises a therapeutically effective amount of active principle(s) or a pharmaceutically acceptable salt or enantiomer or polymorph thereof, optionally one or more release controlling agent(s) and pharmaceutical acceptable excipient(s) thereof, wherein the composition is formulated to increase the residence time of the said pharmaceutical composition and/or active principle(s) in the gastrointestinal tract. A novel pharmaceutical composition comprising at least two entities wherein one entity is an immediate release/fast release and the other is controlled release. A pharmaceutical composition comprising at least two entities wherein one entity is an immediate release/fast release and the other is bioadhesive. A pharmaceutical composition comprising: at least two entities wherein one entity is controlled release and the other is bioadhesive All the three compositions are formulated to increase the residence time of active principle(s) in the gastrointestinal tract.Type: ApplicationFiled: June 24, 2008Publication date: January 8, 2009Applicant: LUPIN LTD.Inventors: Harshal Anil Jahagirdar, Rajesh Kulkarni, Shirishkumar Kulkarni
-
Patent number: 7456296Abstract: A process for preparation of crystalline perindopril erbumine of formula (II) which exhibits the X-ray (powder) diffraction pattern like that shown in FIG. 2 The process comprises reacting a solution of perindopril of formula (I), in a solvent selected from N,N-dimethylformamide, dimethyl acetals of lower aliphatic aldehydes, dimethyl ketals of lower aliphatic ketones and 1,2-dialkoxyethane with tertiary butylamine and crystallization of the erbumine salt thus obtained by heating the reaction mixture to reflux, filtering hot, cooling gradually to 20° C. to 30° C., and further cooling to 0° C. to 15° C. for 30 minutes to 1 hour and finally filtering off and drying the crystals.Type: GrantFiled: October 21, 2003Date of Patent: November 25, 2008Assignee: Lupin LtdInventors: Girij Pal Singh, Himanshu Madhav Godbole, Sagar Purushottam Nehate
-
Patent number: 7427692Abstract: A process for preparation of 7-[D-?-amino-?-(4-hydroxyphenyl)acetamido]-3-(1-propen-1-yl)-3-cephem-4-carboxylic acid viz. Cefprozil of formula (I) in high purity, substantially free of impurities, which comprises preparation of mixed acid anhydride by selecting the sequence and temperature of addition of the reagents and its subsequent condensation with a protected 7-APCA; followed by hydrolysis, isolation and purification to give Cefprozil of formula (I) in the form of a monohydrate.Type: GrantFiled: February 23, 2006Date of Patent: September 23, 2008Assignee: Lupin Ltd.Inventors: Om Dutt Tyagi, Dnyandev Ragho Rane, Tushar Kumar Srivastava, Krishnarao Tukaram Sirsath
-
Publication number: 20080227836Abstract: A stable solid oral dosage form comprising valsartan or a pharmaceutically acceptable salt thereof and pharmaceutically acceptable additives such as sugar (derivatives) and cellulose (derivatives). The active agent is present in an amount less than 35% by weight based on the total weight of the solid oral dosage form. Disclosed is also a process of forming a valsartan-containing composition; which process comprises blending valsartan with pharmaceutically acceptable additives, dry compressing, milling and screening said mixture to obtain granules. Said granules are compressed into tablets and are subsequently coated.Type: ApplicationFiled: October 26, 2006Publication date: September 18, 2008Applicant: Lupin LtdInventors: Makarand Krishnakumar Avachat, Nikhil Prabhakar Malewar, Umesh Nandkumar Khatavkar
-
Publication number: 20070292500Abstract: Extended release pharmaceutical composition of Venlafaxine hydrochloride comprising a pharmaceutically acceptable capsule containing minitablets. The minitablets comprise from about 20% to about 70% by weight effective amount of Venlafaxine hydrochloride, polyvinyl acetate, one or more pharmaceutically acceptable excipients. The minitablets have diameter from about 1 mm to 5 mm and are coated with a release controlling composition.Type: ApplicationFiled: May 21, 2004Publication date: December 20, 2007Applicant: LUPIN LTD.Inventors: Sanjay Wagh, Hidaytulla Aga, Himadri Sen
-
Publication number: 20070286901Abstract: A chewable tablet comprising Cefixime having a mean particle size between 20 ? and 120 ? wherein the said composition demonstrates bioequivalence to a suspension of Cefixime trihydrate. The process of preparation of the chewable tablet comprises the steps of optionally micronizing Cefixime such that the mean particle size of the Cefixime particles is between 20 ? and 120 ?, blending with other excipients, roll compaction, milling to form granules, blending to form a secondary blend and compression of the secondary blend to form tablets.Type: ApplicationFiled: May 10, 2004Publication date: December 13, 2007Applicant: Lupin Ltd.Inventors: Sanjay Wagh, Hidaytulla Aga, Makarand Avachat, Himadri Sen
-
Publication number: 20070149604Abstract: A process for preparation of crystalline perindopril erbumine of formula (II) which exhibits the X-ray (powder) diffraction pattern like that shown in FIG. 2 The process comprises reacting a solution of perindopril of formula (I), in a solvent selected from N,N-dimethylformamide, dimethyl acetals of lower aliphatic aldehydes, dimethyl ketals of lower aliphatic ketones and 1,2-dialkoxyethane with tertiary butylamine and crystallization of the erbumine salt thus obtained by heating the reaction mixture to reflux, filtering hot, cooling gradually to 20° C. to 30° C., and further cooling to 0° C. to 15° C. for 30 minutes to 1 hour and finally filtering off and drying the crystals.Type: ApplicationFiled: October 21, 2003Publication date: June 28, 2007Applicant: Lupin Ltd.Inventors: Girij Singh, Himanshu Godbole, Sagar Nehate
-
Patent number: 7230097Abstract: A process for preparation of 7-[D-?-amino-?-(4-hydroxyphenyl)acetamido]-3-(1-propen-1-yl)-3-cephem-4-carboxylic acid viz. Cefprozil of formula (I) in high purity, substantially free of impurities, which comprises preparation of mixed acid anhydride by selecting the sequence and temperature of addition of the reagents and its subsequent condensation with a protected 7-APCA; followed by hydrolysis, isolation and purification to give Cefprozil of formula (I) in the form of a monohydrate.Type: GrantFiled: March 15, 2004Date of Patent: June 12, 2007Assignee: Lupin Ltd.Inventors: Om Dutt Tyagi, Dnyandev Ragho Rane, Tushar Kumar Srivastava, Krishnarao Tukaram Sirsath
-
Publication number: 20060229438Abstract: The present invention relates to the development of monoclonal antibodies that specifically inhibit DNA gyrase from M. tuberculosis. M. smegmaris and possibly from other related bacterial species. More particularly, it has been shown that the inhibition of the enzyme is by a hitherto unknown and novel mechanism. The present invention also relates to a DNA sequence of single chain antibody consisting of complementarity determining regions of mAb. The monoclonal antibody, single chain antibody and peptides derived thereof could be useful for developing lead molecules for tuberculosis therapy. The antibodies and derived materials could be useful for a variety of purposes, including diagnosis of mycobacterial infections. The present invention also relates to the modification of antibodies and derived materials for use against diverse microbial infections and other potential applications derived thereof.Type: ApplicationFiled: September 20, 2002Publication date: October 12, 2006Applicant: LUPIN LTD.Inventors: Valakunja Nagaraja, Uijini Havaldar, Bhairab Nath
-
Patent number: D948703Type: GrantFiled: July 26, 2019Date of Patent: April 12, 2022Assignee: LUPIN LTD.Inventors: Mukul Dalvi, Imran Shaikh, Xian-Ming Zeng, Antonio Belton
-
Patent number: D948704Type: GrantFiled: July 26, 2019Date of Patent: April 12, 2022Assignee: LUPIN LTD.Inventors: Mukul Dalvi, Imran Shaikh, Xian-Ming Zeng, Antonio Belton
-
Patent number: D949323Type: GrantFiled: July 26, 2019Date of Patent: April 19, 2022Assignee: LUPIN LTD.Inventors: Mukul Dalvi, Imran Shaikh, Xian-Ming Zeng, Antonio Belton
-
Patent number: D949324Type: GrantFiled: December 19, 2019Date of Patent: April 19, 2022Assignee: LUPIN LTD.Inventors: Mukul Dalvi, Imran Shaikh, Xian-Ming Zeng, Antonio Belton