Patents Assigned to Lusochimica S.p.A.
  • Dimethylamine benzoate or p-anisate catalysed process for the preparation of 4-(nitrophenyl)-dihydropyridines
    Patent number: 6015906
    Abstract: A method for the preparation of 4-(nitrophenyl)-dihydro-pyridines by reacting a benzaldehyde with an acetoacetate and reacting the resulting benzylidene derivative with an enamine derivative. Both reactions are catalyzed by dimethylamine benzoate or p-anisate.
    Type: Grant
    Filed: August 18, 1997
    Date of Patent: January 18, 2000
    Assignee: Lusochimica S.p.A.
    Inventors: Bruno Perego, Elso Manghisi
  • Process for the preparation of diltiazem
    Patent number: 5382663
    Abstract: (+)-Cis-3-(acetoxy)-5-[2-(dimethylamino)-ethyl]-2,3-dihydro-2-(4-methoxyphe nyl)-1,5-benzothiazepin-4(5H)-one hydrochloride is prepared by N-alkylation of (+)-cis-3-hydroxy-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H) -one with dimethylaminoethyl chloride and K.sub.2 CO.sub.3 in toluene/water, addition of a solubilizing agent and in the presence of a phase-transfer catalyst, the toluene phase being directly subjected to the final O-- acetylation.
    Type: Grant
    Filed: June 23, 1993
    Date of Patent: January 17, 1995
    Assignee: Lusochimica S.p.A.
    Inventors: Elso Manghisi, Bruno Perego