Abstract: A method of macular disease treatment (500) may include introducing nanocapsules into a body of a patient (502). The nanocapsules may be introduced such that the nanocapsules circulate through at least a portion of a body of the patient. A therapeutic substance and a colorant may be encapsulated into the nanocapsules. After a portion of the nanocapsules enters choroidal neovessels of an eye of the patient, the method may include emitting a pulsed laser radiation through a pupil of the eye (504). Additionally, after a portion of the nanocapsules enters choroidal neovessels of an eye of the patient, the method may include heating the portion of the nanocapsules present in the eye (506) such that at least a portion of the nanocapsules transfer phase and release the therapeutic substance.

Abstract: An optical device can include: an incident light polarizer positioned to receive incident light and configured to polarize incident light such that polarized incident light is directed to a cornea of a subject; at least one corneal light polarizer, wherein the at least one corneal light polarizer is positioned to receive reflected light from the cornea of the subject and polarize the reflected light to a second polarization; at least one rotating mechanism; and at least one receiver. The receiver can be at least one viewing port optically coupled with the at least one corneal light polarizer or an imaging device (e.g., optical detector). The at least one rotating mechanism is: coupled with the incident light polarizer; coupled with the at least one corneal light polarizer; or coupled with the incident light polarizer and the at least one corneal light polarizer.

Abstract: a laser-based ophthalmological treatment system(200) may include a device housing(202), a head fixation assembly(206), and an interactive display device(324, 424). The head fixation assembly(206) may be configured to position and to retain a head of a patient relative to the device housing(202). The interactive display device(324,424) may be positioned in an optical path(304,404). The interactive display device(324,424) may be fixed relative to the head fixation assembly(206). The interactive display device(324,424) may be configured to display a simulation scene(504) that may include a target image(502) into a visual field of the patient. The target image(502) may be displayed in the simulation scene(504) such that optical focus on the target image(502) by the patient aligns a portion of a fundus(130) of an eye of the patient in the optical path(304,404).

Abstract: In some examples, a laser-based ophthalmological surgical system (hereinafter “system”) includes a therapeutic radiation source configured to emit therapeutic radiation with a first wavelength. The system may also include a probe radiation source configured to emit probe radiation with a second wavelength different than the first wavelength. The system may also include one or more optical elements configured to direct the therapeutic radiation and the probe radiation into an eye of a patient and to collect reflected probe radiation from the eye of the patient. The reflected probe radiation may be indicative of an amount of therapeutic radiation exposure of the eye of the patient. The system may also include a photodetector configured to receive the reflected probe radiation from the one or more optical elements and to generate a photocurrent indicative of the amount of therapeutic radiation exposure of the eye of the patient.

Abstract: In some examples, a distributed acoustic detector system may include a frame structure and multiple acoustic detectors. The frame structure may be configured to be retained in a laser-based ophthalmo-logical surgical system aligned to an eye of a patient during therapeutic treatment of the eye of the patient with the laser-based ophthalmological surgical system. The acoustic detectors may be coupled to the frame structure and may be spaced apart from each other and electrically separated from each other.

Abstract: In some examples, a laser-based ophthalmological surgical system (hereinafter “system”) includes a therapeutic radiation source configured to emit therapeutic radiation at a first intensity during a therapeutic portion and to emit probe radiation with a second intensity which is less than the first intensity during a probe portion. The system may also include one or more optical elements configured to direct the therapeutic portion and the probe portion into an eye of a patient and to collect reflected radiation from the eye of the patient. The reflected radiation may be indicative of dynamics of microbubbles in the cells of the eye of the patient.

Abstract: A contact assembly (301,400) for laser surgery may include a contact lens (402) and an optical filter (404). The contact lens (402) may be configured to be positioned in an optical path of therapeutic radiation (310) directed at an eye (100) of a patient. The optical filter (404) may be coupled to an outer surface (402A) of the contact lens (402). The optical filter (404) may be transparent to the therapeutic radiation (310) with a first wavelength and may be opaque to radiation (318) with a second wavelength different than the first wavelength.

Abstract: Technologies are generally described for normalized standard deviation transition based dosimetry monitoring for laser treatment. In some examples, a response signal may be generated based on a physical response to a laser pulse detected through acoustic or optical means. Each response signal may be a time series of data with a number of points. Standard deviation may be determined for each response signal and normalized using a mean or comparable normalization factor. Thus, a robust distribution may be computed from the response to each laser pulse. A change in the normalized standard deviation from each single pulse's time domain response data may be used to determine how many laser pulses remain before completion of the treatment (similar to event onset response). Thus, laser treatment may be continued based on an estimation of remaining pulses for completion or ceased if completion is reached.

Abstract: A lens/sensor subassembly (318) may include a feedback sensor (324), a data transmission line (302), and an electrical element (328). The feedback sensor (324) may be configured to measure a phenomenon in an eye (100) of a patient during a laser-based ophthalmological therapy. The data transmission line (302) may be configured to communicate feedback data measured by the feedback sensor (324) to a laser-based ophthalmological treatment system (200). The electrical element (328) may be degradable in response to exposure to therapeutic radiation (316). The degradation of the electrical element (328) may interrupt communication of the feedback data measured by the feedback sensor (324) to the laser-based ophthalmological treatment system (200).

Abstract: Technologies are described for monitoring efficacy of laser treatment through cell lysis determination. Current methods for removing diseased tissue may include directing laser treatment toward cells in a treatment area. The laser treatment may induce lysis of the cells without any visual indication of the lysis occurring. According to some examples, a treatment system may direct a pair of laser pulses to cells in a treatment area. The treatment system may derive a first signal and a second signal based on a detected response to the first and second laser pulse within the pair. A signal processor, according to some examples, may determine a difference between the first signal and the second signal and may modify the laser treatment based on the difference.

Abstract: Technologies are described for detection of eye surface vibrations to determine cell damage within a treatment area of an eye undergoing laser treatment. Eye surface vibrations may be caused by intraocular pressure waves that form during the laser treatment. For example, the pressure waves may originate from a plurality of bubbles forming and/or rupturing inside cells located in the treatment area. The bubbles may form as energy from a treatment laser beam is absorbed by the retinal tissue. The pressure waves may be measured at the surface of the eye through Doppler vibrometry to determine if the cells within the treatment area have been damaged. The damage to the cells may include cell lysis, a rupture of cell membranes, scarring, and/or photocoagulation, among other examples.

Abstract: A dosimetry system may comprise a film stack and a laser system for applying a laser beam to the film stack. The system may further comprise an interferometry system configured to acquire from the film stack a first interferometric dataset comprising a first composite signal and a subsequent interferometric dataset comprising a subsequent composite signal. The system may also include a processor for comparing the first and subsequent composite signals, wherein a difference between the first and subsequent composite signals indicates a change in the film stack thickness. A dosimetry method may comprise applying a laser beam to such a film stack, acquiring the first and subsequent interferometric datasets, comparing them to detect a change in the film stack thickness, and ceasing to apply the laser beam to the film stack if the change in the film stack thickness exceeds a predetermined threshold.

Abstract: The present invention relates to an ophthalmic treatment device and a method of operating same, and provides an ophthalmic treatment device and a method of operating same, the device comprising: a treatment beam generating unit for generating a treatment beam; a beam delivery unit for forming a path through which the treatment beam generated by the treatment beam generating unit travels to a treatment region disposed in a fundus; a monitoring unit for irradiating a detecting beam along the path through which the treatment beam travels, and detecting information of the state of the treatment region based on interference information on the detecting beam reflected from the treatment region; and a controller for controlling the operation of the treatment beam generating unit based on information on the state of the treatment region detected by the monitoring unit.

Abstract: A contact lens, according to the present invention, comprises: a housing having a light-incident part on which a therapeutic beam oscillated from a beam generation part is incident, and a light-emitting part for guiding the therapeutic beam incident from the light-incident part to an eyeball; a first sensing part arranged between the light-incident part and the light-emitting part so as to sense the reaction occurring in a healing site of the eyeball on which the therapeutic beam is irradiated; and a second sensing part arranged in a region of the light-emitting part spaced from the first sensing part so as to sense whether contact has been made with the eyeball.

Abstract: The present invention relates to an ophthalmic treatment apparatus and to a treatment beam radiating method for the apparatus. The ophthalmic treatment apparatus according to the present invention comprises: a beam generating unit for generating a treatment beam; a beam delivery unit for delivering the treatment beam generated by the beam generating unit to the retinal region of an eyeball; an image unit for forming an image of the retinal region of the eyeball in the horizontal direction with respect to the plane of the focal spot of the treatment beam guided by the beam delivery unit; and a control unit for controlling the beam delivery unit such that the location of the plane of the focal spot can be adjusted based on the curvature of the retinal region of the eyeball imaged by the image unit.

Abstract: The present invention relates to an ophthalmic treatment device, a control method therefor and a fundus lesion treatment method, the ophthalmic treatment device comprising: a treatment beam generation unit for generating a treatment beam; a beam delivery unit for forming a path through which the treatment beam generated from the treatment beam generating unit is irradiated into a patient's fundus; and a control unit for controlling the beam delivery unit to irradiate the treatment beam into a location adjacent to the lesion area of the fundus.

Abstract: A drusen treatment method includes confirming a location of drusen in a fundus of a patient; determining a treatment area by including a location on which the drusen exists; and removing the drusen by transferring energy to the treatment area.

Abstract: The present invention relates to an ophthalmic apparatus and to a treatment site measuring method for the apparatus. The ophthalmic apparatus according to the present invention comprises: a first image unit for capturing the lower region of a retina so as to generate an image of the captured retina; a second image unit for capturing the local region of the retina indicated by a surgical operator so as to generate an image of the captured local region of the retina; and a control unit for mapping the image of the local region of the retina generated by the second image unit to the image of the retina generated by the first image unit based on the image of the retina generated by the first image unit.

Abstract: The present invention relates to an ophthalmic treatment apparatus and to a beam control method therefor. The ophthalmic treatment apparatus according to the present invention comprises: a beam generating unit for generating beams having different pulse energies; a bubble sensing unit for sensing whether or not bubbles have been generated, as well as the amount of generated bubbles, on the basis of the pulse energy of the beam generated by the beam generating unit and radiated onto the treatment region of an eyeball; and a control unit for controlling the operation of the beam generating unit such that the pulse energy of the beam generated by the beam generating unit can be adjusted in accordance with the signal from the bubble sensing unit.

Abstract: The present invention relates to an ophthalmic apparatus and to a treatment site measuring method for the apparatus. The ophthalmic apparatus according to the present invention comprises: a first image unit for capturing the lower region of a retina so as to generate an image of the captured retina; a second image unit for capturing the local region of the retina indicated by a surgical operator so as to generate an image of the captured local region of the retina; and a control unit for mapping the image of the local region of the retina generated by the second image unit to the image of the retina generated by the first image unit based on the image of the retina generated by the first image unit.