Patents Assigned to Lygos, Inc.
  • Recombinant host cells and methods for the production of glyceric acid and downstream products
    Patent number: 12188008
    Abstract: Methods and materials related to producing glyceric acid and downstream products are disclosed. Specifically, isolated nucleic acids, polypeptides, host cells, methods and materials for producing glycolic acid by direct fermentation from sugars are disclosed.
    Type: Grant
    Filed: February 18, 2019
    Date of Patent: January 7, 2025
    Assignee: Lygos, Inc.
    Inventors: Jeffrey A. Dietrich, Mario Ouellet, Johan van Walsem
  • Advanced production of cannabinoids in yeast
    Patent number: 12043860
    Abstract: Exemplary embodiments provided herein include genetically engineering microorganisms, such as yeast or bacteria, to produce cannabinoids by inserting genes that produce the appropriate enzymes for the metabolic production of a desired compound.
    Type: Grant
    Filed: April 1, 2022
    Date of Patent: July 23, 2024
    Assignee: Lygos, Inc.
    Inventors: Jason L. Poulos, Anthony N. Farina
  • Recombinant host cells and methods for the production of D-lactic acid
    Patent number: 11390891
    Abstract: Methods and materials related to producing D-lactic acid are disclosed. Specifically, isolated synthetic or natural nucleic acids, synthetic or natural polypeptides, host cells, and methods and materials for producing D-lactic acid by direct fermentation from carbon sources are disclosed, along with methods of preparing D-lactic acid polymers.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: July 19, 2022
    Assignee: Lygos, Inc.
    Inventors: Jeffrey A. Dietrich, Mario Ouellet, Andrew Jonathan Conley
  • Process for purification of malonic acid from fermentation broth
    Patent number: 11326191
    Abstract: A process for the preparation of bio-based malonic acid and crystalline calcium malonate is provided. The calcium malonate is highly pure and provides a source of malonic acid made from a renewable carbon source rather than existing processes which rely on the use of petroleum-based products. The calcium malonate provides an improved source of malonic acid, which is important to many industrial processes.
    Type: Grant
    Filed: November 14, 2017
    Date of Patent: May 10, 2022
    Assignee: Lygos, Inc.
    Inventors: Eric Steen, Jeffrey Dietrich, Johan Van Walsem
  • Recombinant host cells and methods for the production of L-lactic acid
    Patent number: 11268112
    Abstract: Provided herein are recombinant fungal or bacterial cells comprising a heterologous L-lactate dehydrogenase, and processes of preparing L-lactic acid employing such cells.
    Type: Grant
    Filed: April 11, 2019
    Date of Patent: March 8, 2022
    Assignee: Lygos, Inc.
    Inventors: Andrew Jonathan Conley, Mario Ouellet, Jeffrey A. Dietrich
  • Recombinant host cells for the production of malonate
    Patent number: 11248215
    Abstract: Systems and methods for the production of malonate in recombinant host cells.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: February 15, 2022
    Assignee: Lygos, Inc.
    Inventors: Jeffrey A. Dietrich, Jeffrey L. Fortman, Eric J. Steen
  • Recombinant host cells for the production of malonate
    Patent number: 10472653
    Abstract: Systems and methods for the production of malonate in recombinant host cells.
    Type: Grant
    Filed: June 19, 2017
    Date of Patent: November 12, 2019
    Assignee: Lygos, Inc.
    Inventors: Jeffrey A. Dietrich, Jeffrey L. Fortman, Eric J. Steen
  • Recombinant host cells for the production of malonate
    Patent number: 10385368
    Abstract: Compositions and methods for producing malonate in recombinant host cells in order to increase malonate titer, yield, and/or productivity are provided. Recombinant host cells comprising nucleic acids encoding MAE1 transport proteins that increase production of malonate by the host cell and vectors for expressing MAE1 transport proteins that increase production of malonate by the host cell are also disclosed.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: August 20, 2019
    Assignee: Lygos, Inc.
    Inventor: Jeffrey A. Dietrich
  • RECOMBINANT HOST CELLS AND METHODS FOR THE PRODUCTION OF L-ASPARTATE AND BETA-ALANINE
    Publication number: 20180258437
    Abstract: Recombinant host cells, materials, and methods for the biological production of L-aspartate and/or beta-alanine under substantially anaerobic conditions.
    Type: Application
    Filed: May 10, 2018
    Publication date: September 13, 2018
    Applicant: Lygos, Inc.
    Inventor: Jeffrey A. Dietrich
  • RECOMBINANT HOST CELLS FOR THE PRODUCTION OF MALONATE
    Publication number: 20170362614
    Abstract: Systems and methods for the production of malonate in recombinant host cells.
    Type: Application
    Filed: June 19, 2017
    Publication date: December 21, 2017
    Applicant: Lygos, Inc.
    Inventors: Jeffrey A. Dietrich, Jeffrey L. Fortman, Eric J. Steen
  • Recombinant host cells for the production of malonate
    Patent number: 9816114
    Abstract: Systems and methods for the production of malonate in recombinant host cells.
    Type: Grant
    Filed: March 6, 2013
    Date of Patent: November 14, 2017
    Assignee: Lygos, Inc.
    Inventors: Jeffrey A. Dietrich, Jeffrey L. Fortman, Eric J. Steen