Abstract: This invention relates to an injectable, stable, sterile aqueous solution of cisplatin in a unit dosage form in a sealed container, the solution being suitable for administration by the injection thereof into man upon the removal thereof from the container, the solution consisting of water and cisplatin, said solution having a concentration of cisplatin between about 0.1 and about 1.3 mg/mL, and a pH in the range of about 3.5 to about 5.0, the solution being substantially free of dissolved oxygen.

Abstract: Nitroglycerin injection that is free of the customary organic solvents and has an extended shelf life of at least 1 year, consisting essentially of water, lactose, and nitroglycerin. Sodium chloride or dextrose may be added during manufacture or upon diluting with an infusion. Commerically safe manufacture and stable dispersion are assured by mixing lactose adsorbate, containing nitroglycerin, with water at high shear so that no nitroglycerin droplets coalesce. Stability is maintained by filtering and filling operations using nonreactive, nonleaching, nonadsorptive materials.

Abstract: A storage-stable liquid oncolytic formulation of cyclophosphamide for parenteral administration is presented. Currently utilized lyophilized formulations have inherent diseconomies and increased hazard is associated with reconstitution. The liquid formulations of the present invention comprise a solution of cyclophosphamide with an organic polyol as cosolvent, which provide enhanced shelf-life and greater ease of administration. The polyol is either propylene glycol, polyethylene glycol or glyerol. The solution of cyclophosphamide is either aqueous, or in the case of propylene glycol may constitute 10-30% by weight of an alcohol.

Abstract: A medicinal vial cover for preventing the introduction of a liquid solution to atmosphere during the removal of the solution from a container of the type having an axially-extending neck and an entrance opening coaxial with the neck in which the opening is sealed by a rubber plug through which a hypodermic needle is inserted to extract the solution into a syringe, the cover having a tip at one of its ends and a hollow base at its other end adapted to be attached over the neck of the container. A hypodermic needle can then be inserted through both the cover and the rubber plug to withdraw the solution into a syringe with any aerosol or droplets being trapped within the cover.