Patents Assigned to Lyt, Inc.
  • Publication number: 20250164261
    Abstract: A computer system that coordinates traffic management is described. During operation, the computer system may receive information from a traffic-management system of an environment and second information from at least an instance of traffic-mapping software associated with an electronic device of a user, where the information specifies the traffic-light patterns in a time interval. Then, the computer system may compute a route, for at least a vehicle associated with the user from a current location associated with the electronic device to a destination based at least in part on the information and the second information. Next, the computer system may provide instructions addressed to the electronic device, where the one or more instructions specify the computed route.
    Type: Application
    Filed: November 20, 2024
    Publication date: May 22, 2025
    Applicant: Lyt, Inc.
    Inventors: Timothy Menard, Dustin Harber, Shmuel Silverman
  • Publication number: 20250124791
    Abstract: A computer system that coordinates traffic management is described. During operation, the computer system may receive information from a traffic-management system of an environment and second information from at least an instance of traffic-mapping software associated with an electronic device of a user. Then, the computer system may compute a route, for at least a vehicle associated with the user from a current location associated with the electronic device to a destination based at least in part on the information and the second information. Next, the computer system may provide instructions addressed to the electronic device, where the one or more instructions specify the computed route.
    Type: Application
    Filed: October 15, 2024
    Publication date: April 17, 2025
    Applicant: Lyt, Inc.
    Inventors: Timothy Menard, Dustin Harber, Shmuel Silverman
  • Patent number: 12084500
    Abstract: Disclosed herein are antibodies specific to a delta-1 chain of a ?? T cell receptor and methods of using such for modulating ?? T cell bioactivity. Such anti-Delta 1 antibodies may also be used to treat diseases associated with ?? T cell activation, such as solid tumors, or for detecting presence of ??1 T cells.
    Type: Grant
    Filed: January 23, 2020
    Date of Patent: September 10, 2024
    Assignees: New York University, PureTech LYT, Inc.
    Inventors: Shohei Koide, George Miller, Akiko Koide, Tatyana Panchenko, Takamitsu Hattori, Aleksandra Filipovic, Eric Elenko, Joseph Bolen
  • Publication number: 20240287195
    Abstract: Methods for treating an ocular melanoma in a patient. e.g., uveal melanoma, comprising administering to the patient an effective amount of an antibody that binds galectin-9). Also provided herein are methods for identifying a subject as having the ocular melanoma based on the level of Galectin-9) in a biological sample (e.g., a blood sample) from a subject suspected of having the ocular melanoma.
    Type: Application
    Filed: October 26, 2021
    Publication date: August 29, 2024
    Applicant: PURETECH LYT, INC.
    Inventors: Aleksandra FILIPOVIC, Joseph BOLEN, Eric ELENKO
  • Publication number: 20240245788
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Application
    Filed: January 10, 2024
    Publication date: July 25, 2024
    Applicants: PureTech LYT, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Rishab R. Shyam, Jamie Simpson, Christopher John Porter, Natalie Trevaskis, Tim Quach, Sifei Han, Luojuan Hu
  • Publication number: 20240190970
    Abstract: Disclosed herein are methods for treating solid tumors (e.g., pancreatic ductal adenocarcinoma (PDAC), colorectal cancer (CRC), hepatocellular carcinoma (HCC), cholangiocarcinoma (CAA), renal cell carcinoma (RCC), urothelial, head and neck, breast cancer, lung cancer, or other gastrointestinal solid tumors), using an anti-Galectin-9) antibody, e.g., as a monotherapy or as a combined therapy with an immune checkpoint inhibitor.
    Type: Application
    Filed: April 29, 2022
    Publication date: June 13, 2024
    Applicant: PURETECH LYT, INC.
    Inventors: Aleksandra FILIPOVIC, Eric ELENKO, Heather PADEN, Christopher KORTH
  • Publication number: 20240182583
    Abstract: Disclosed herein are combined therapies for treating solid tumors (e.g., pancreatic ductal adenocarcinoma (PDAC), colorectal cancer (CRC), hepatocellular carcinoma (HCC), cholangiocarcinoma (CAA), renal cell carcinoma (RCC), urothelial, head and neck, breast cancer, lung cancer, or other gastrointestinal solid tumors), comprising an antibody that binds human galectin-9 (anti-Gal9) antibody, e.g., G9.2-17), and one or more chemotherapeutics, for example, gemcitabine, paclitaxel, or a combination thereof.
    Type: Application
    Filed: April 29, 2022
    Publication date: June 6, 2024
    Applicant: PURETECH LYT, INC.
    Inventors: Aleksandra FILIPOVIC, Eric ELENKO, Heather PADEN, Christopher KORTH
  • Patent number: 11975073
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Grant
    Filed: June 26, 2023
    Date of Patent: May 7, 2024
    Assignees: PureTech LYT, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Rishab R. Shyam, Jamie Simpson, Christopher John Porter, Natalie Trevaskis, Tim Quach, Sifei Han, Luojuan Hu
  • Patent number: 11938137
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Grant
    Filed: January 27, 2022
    Date of Patent: March 26, 2024
    Assignees: PureTech LYT, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Ketki Karanam, Sifei Han, Luojuan Hu, Christopher John Hamilton Porter, Tim Quach, Rishab R. Shyam, Jamie Simpson, Natalie Trevaskis
  • Patent number: 11883497
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a provided lipid prodrug or a pharmaceutical composition thereof.
    Type: Grant
    Filed: August 29, 2018
    Date of Patent: January 30, 2024
    Assignees: PureTech LYT, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Ketki Karanam, James T. Mutamba, Rishab R. Shyam, Jamie Simpson, Sifei Han, Luojuan Hu, Christopher John Hamilton Porter, Tim Quach, Natalie Trevaskis
  • Publication number: 20240021076
    Abstract: A computer system that manages traffic flow is described. During operation, the computer system may receive information specifying or corresponding to an estimated time of arrival of a vehicle at an intersection. Then, the computer system may receive second information corresponding to traffic conditions in an environment (such as traffic flows), where the traffic conditions are associated with one or more other intersections that input traffic to the intersection, that received output traffic from the intersection, or both, and at least a subset of the one or more other intersections are not along a route of the vehicle. Next, based at least in part on the estimated time of arrival and the traffic conditions associated with the one or more other intersections, the computer system may selectively modify traffic management in at least one of the one or more other intersections.
    Type: Application
    Filed: March 25, 2023
    Publication date: January 18, 2024
    Applicant: Lyt, Inc.
    Inventors: Timothy Menard, Dustin Harber, Murad Salahi
  • Publication number: 20230338552
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Application
    Filed: June 26, 2023
    Publication date: October 26, 2023
    Applicants: PureTech LYT, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Rishab R. Shyam, Jamie Simpson, Christopher John Porter, Natalie Trevaskis, Tim Quach, Sifei Han, Luojuan Hu
  • Publication number: 20230146697
    Abstract: A computer system that performs a remedial action is described. During operation, the computer system may receive information corresponding to traffic conditions in an environment (such as traffic flows in at least a portion of a city), where the information is associated with different types of sources distributed in the environment, and the environment includes multiple intersections and roadways. Then, the computer system may identify an event in at least a portion of the environment based at least in part on the information, such as predicting a change in a traffic condition in the environment in a subsequent time interval. Next, the computer system may perform a remedial action based at least in part on the identified event, such as: providing an alert about the event; providing an instruction based at least in part on the event; and/or modifying traffic management in at least the portion of the environment.
    Type: Application
    Filed: November 8, 2022
    Publication date: May 11, 2023
    Applicant: Lyt, Inc.
    Inventors: Timothy Menard, Dustin Harber
  • Patent number: 11608345
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: March 21, 2023
    Assignees: PureTech LYT, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Sifei Han, Luojuan Hu, Ketki Karanam, Christopher John Porter, Tim Quach, Rishab R. Shyam, Jamie Simpson, Natalie Trevaskis
  • Publication number: 20220395513
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Application
    Filed: August 4, 2022
    Publication date: December 15, 2022
    Applicants: PureTech LYT, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Rishab R. Shyam, Jamie Simpson, Christopher John Porter, Natalie Trevaskis, Tim Quach, Sifei Han, Luojuan Hu
  • Publication number: 20220143038
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Application
    Filed: January 27, 2022
    Publication date: May 12, 2022
    Applicants: PureTech LYT, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Ketki Karanam, Sifei Han, Luojuan Hu, Christopher John Hamilton Porter, Tim Quach, Rishab R. Shyam, Jamie Simpson, Natalie Trevaskis
  • Patent number: 11304954
    Abstract: The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, and methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: April 19, 2022
    Assignees: PureTech LYT, Inc., Monash University
    Inventors: Daniel Kenneth Bonner, Ketki Karanam, Sifei Han, Luojuan Hu, Christopher John Hamilton Porter, Tim Quach, Rishab R. Shyam, Jamie Simpson, Natalie Trevaskis
  • Publication number: 20210290538
    Abstract: The present disclosure provides milk vesicles as drug delivery vehicles, compositions comprising a therapeutic agent encapsulated within or otherwise associated with the milk vesicles, methods of producing such milk vesicles and compositions thereof, as well as methods of delivering such milk vesicles and compositions to a specific patient tissue or organ. Also provided herein is a composition comprising milk vesicles, wherein the milk vesicles comprise a lipid membrane to which one or more proteins are associated, and wherein (a) a relative abundance of casein in the composition is less than about 40%, and/or (b) a relative abundance of lactoglobulin in the composition is less than about 25%.
    Type: Application
    Filed: July 2, 2019
    Publication date: September 23, 2021
    Applicant: PureTech LYT, Inc.
    Inventors: Joseph Bolen, Rishab Shyam, Nicholas Pilla, Katerina Krumova, Bhushan Pattni, Daniel Bonner
  • Publication number: 20210177757
    Abstract: The present invention provides exosomes as drug delivery vehicles, compositions comprising a therapeutic agent encapsulated within such exosomes, methods of producing such exosomes and compositions thereof, as well as methods of delivering such exosomes and compositions to a specific patient tissue or organ. The present invention also provides methods of treating a disease, disorder, or condition such as cancer, an inflammatory disease, an infectious disease, an allergic disease, or an autoimmune disease, comprising administering to a patient in need thereof a provided therapeutic-loaded exosome or a pharmaceutical composition thereof.
    Type: Application
    Filed: July 29, 2020
    Publication date: June 17, 2021
    Applicant: PURETECH LYT, INC.
    Inventors: Joseph Bolen, Daniel Kenneth Bonner, Lisa V. Ferreira, Katerina Krumova, John Jantz, James Tendai Mutamba, Rishab R. Shyam