Abstract: The present invention relates to a surface expression vector having pgsBCA, a gene coding poly-gamma-glutamate synthetase and a method for expression of target protein at the surface of microorganism using the vector. The vector, in which foreign genes are inserted, transforms microorganisms and makes foreign proteins expressed stably on the surface of microorganisms.
Type:
Grant
Filed:
August 9, 2002
Date of Patent:
June 30, 2009
Assignees:
Bioleaders Corporation, M.D. Lab Co., Ltd., Department of Veterinary Science Chung Nam University
Abstract: The present invention relates to a composition for an immunopotentiator (adjuvant) containing poly-gamma-glutamic acid and a composition for a vaccine containing the immunopotentiator, and more particularly, to an immunopotentiator containing poly-gamma-glutamic acid capable of enhancing antibody production rate by administering it to an animal together with antigen having low immunogenicity, and a composition for a vaccine containing the immunopotentiator and antigen. The inventive adjuvant has almost no toxicity and side effects, and show high antibody titer even when it is used with antigen having poor immunogenicity, so it can be used by adding to medical composition including preventive or curative vaccine for non-contagious chronic diseases as well as cancer, especially prostatic carcinoma, colon carcinoma, lung cancer, breast cancer, ovarian cancer, head and neck cancer, pudendum cancer, bladder cancer, brain tumor and glioma.
Type:
Application
Filed:
December 6, 2005
Publication date:
June 26, 2008
Applicants:
BIOLEADERS CORPORATION, M.D. LAB CO., LTD, Korea Research Institute Of Bioscience and Biotechnology
Inventors:
Moon-Hee Sung, Chul-Joong Kim, Ha Ryoung Poo, Seung Pyo Hong, Jong Soo Lee, Ji Youn Kim