Abstract: Machines for manufacturing cardboard packaging boxes including a conveyor system for advancing sheets (F) of cardboard from an inlet station to a output station are provided. Such machines may include a cutting station, for making cuts in the sheets (F) in predetermined positions, and a folding and gluing station, downstream of the cutting station, for folding the sheets along score lines and applying adhesive to the sheets. The cutting station may be provided with one or more laser devices, associated with servomechanisms controlled in synchronization with the conveyor system, for directing laser beams which make cuts and/or score lines in the sheets (F) moved by the conveyor system.