Abstract: The subject matter of the present invention is the novel molecules of formulae E, E? and F. These molecules prove to be synthesis intermediates that are very advantageous for the manufacture of derivatives of sphingosine or of ceramides functionalized in position 1, with good yields, in which R1 and R2 are fatty chains, R3 is an alkyl group and R4 is a protective group for alcohol functions. Another subject of the invention is the use of the intermediates of type F for converting same into intermediates of type G, by means of reduction in the presence of lithium borohydride. The G molecules are precursors that are known to make it possible to obtain sphingolipids or sphingomyelin.
Type:
Grant
Filed:
January 14, 2014
Date of Patent:
October 17, 2017
Assignee:
M2I DEVELOPMENT
Inventors:
Loic Guilloneau, Samuel Dufour, Olivier Guerret
Abstract: The present invention concerns novel chemical compounds corresponding to formulae (I) and (II): (I) (II) which, when marked with fluorine-18, can be used as markers of NMDA receptors for carrying out studies with a scanner.
Type:
Grant
Filed:
May 27, 2014
Date of Patent:
July 25, 2017
Assignee:
M2I DEVELOPMENT
Inventors:
Olivier Guerret, Samuel Dufour, Hafid Belhadj-Tahar
Abstract: The present invention relates to a process for preparing sordidin, comprising a step of preparing 4-(2-ethyl-1,3-dioxolan-2-yl)pentan-2-one by means of a reaction in which 2-ethyl-2-(pent-4-en-2-yl)-1,3-dioxolane is oxidized in the presence of a catalyst chosen from the group comprising organometallic complexes of transition metals.
Type:
Grant
Filed:
December 30, 2014
Date of Patent:
May 30, 2017
Assignees:
M2I DEVELOPMENT, M2I SALIN
Inventors:
Samuel Dufour, Valérie LeJeune, Hubert Sevestre
Abstract: The present invention relates to a process for preparing sordidin, comprising a step of preparing 4-(2-ethyl-1,3-dioxolan-2-yl)pentan-2-one by means of a reaction in which 2-ethyl-2-(pent-4-en-2-yl)-1,3-dioxolane is oxidized in the presence of a catalyst chosen from the group comprising organometallic complexes of transition metals.
Type:
Application
Filed:
December 30, 2014
Publication date:
December 8, 2016
Applicants:
M2I DEVELOPMENT, M2I SALIN
Inventors:
Samuel DUFOUR, Valérie LEJEUNE, Hubert SEVESTRE
Abstract: The present invention concerns novel chemical compounds corresponding to formulae (I) and (II): (I) (II) which, when marked with fluorine-18, can be used as markers of NMDA receptors for carrying out studies with a scanner.
Type:
Application
Filed:
May 27, 2014
Publication date:
April 21, 2016
Applicant:
M2I DEVELOPMENT
Inventors:
Olivier GUERRET, Samuel DUFOUR, Hafid BELHADJ-TAHAR
Abstract: The subject matter of the present invention is the novel molecules of formulae E, E? and F. These molecules prove to be synthesis intermediates that are very advantageous for the manufacture of derivatives of sphingosine or of ceramides functionalized in position 1, with good yields, in which R1 and R2 are fatty chains, R3 is an alkyl group and R4 is a protective group for alcohol functions. Another subject of the invention is the use of the intermediates of type F for converting same into intermediates of type G, by means of reduction in the presence of lithium borohydride. The G molecules are precursors that are known to make it possible to obtain sphingolipids or sphingomyelin.
Type:
Application
Filed:
January 14, 2014
Publication date:
March 24, 2016
Applicant:
M2I DEVELOPMENT
Inventors:
Loic GUILLONEAU, Samuel DUFOUR, Olivier GUERRET