Abstract: Antibodies having a high specificity and high affinity towards the human gene product MUC1, which in specific variants is associated with neoplastic cells, i.e. tumor tissue, to the use of the antibodies for medical purposes, i.e. for tumor treatment, and for analytical purposes, e.g. for tumor diagnosis. Compositions comprising the antibodies, e.g. for use in the analytical processes and analysis, to pharmaceutical compositions comprising the antibodies, and to use of the antibodies in the manufacture of pharmaceutical compositions for tumor treatment or for diagnostic purposes.
Type:
Grant
Filed:
July 17, 2009
Date of Patent:
January 17, 2017
Assignee:
MAB FACTORY GMBH
Inventors:
Christian Behrens, Holger Thie, Michael Hust, Lars Toleikis, Thomas Schirrmann, Stefan Dübel, Christophe De Romeuf
Abstract: The present invention provides a novel antibody-RNase conjugate which is a single chain protein, providing both the specificity of its antibody portion and the RNase activity of its RNase portion, resulting in an antigen specific effectiveness against cells when applied in vivo or in vitro, wherein the RNase portion is effectively cytotoxic in at least a fraction of cells presenting the antigen, e.g. after internalization by endocytosis. In detail, the present invention provides scAb-RNase conjugate having the principal structure of scFvFc-RNase. This structure could also be shown to allow the effective production of antigen-specific and cytotoxic conjugate protein in cell culture, the conjugate having a high activity with respect to antigen specificity and cyto toxicity.
Type:
Application
Filed:
April 24, 2007
Publication date:
January 21, 2010
Applicant:
MAB-FACTORY GMBH
Inventors:
Stefan Dubel, Thomas Schirrmann, Thomas Jostok, Christian Menzel