Patents Assigned to Macfarlan Smith Limited
  • Processes for making a solid-state form of relugolix
    Patent number: 11655256
    Abstract: The present invention is directed to processes for making an anhydrous form of relugolix, designated herein as Form T of anhydrous relugolix. The processes of making Form T of anhydrous relugolix are from the following: (i) Form A of the DMF solvate of relugolix; (ii) Form B of anhydrous relugolix; or (iii) amorphous relugolix.
    Type: Grant
    Filed: November 6, 2021
    Date of Patent: May 23, 2023
    Assignee: Macfarlan Smith Limited
    Inventor: Nicholas Paschalides
  • Solid-state forms of Regadenoson, their use and preparation
    Patent number: 11535644
    Abstract: The invention relates to a crystalline methanol or dimethyl sulfoxide solvated form of regadenoson and an anhydrous polymorph of regadenoson. The invention is also directed to the preparation of the methanol or dimethyl sulfoxide solvated and anhydrous solid-state forms of regadenoson. In particular, the invention relates to the preparation of the anhydrous polymorph of regadenoson in a stable form from the dimethyl sulfoxide solvated form of regadenoson, which preparation is purifiable and scalable.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: December 27, 2022
    Assignee: Macfarlan Smith Limited
    Inventor: Padmini Kavuru
  • Niraparib solid state form
    Patent number: 11524953
    Abstract: The present disclosure relates to a stabilized anhydrous p-toluenesulfonic acid salt of niraparib, Form A. The present disclosure is also related to processes for the preparation of the stabilized anhydrous p-toluenesulfonic acid salt of niraparib. Further, the present disclosure also relates to pharmaceutical compositions comprising the stabilized anhydrous p-toluenesulfonic acid salt of niraparib and methods for treating disease using the stabilized anhydrous p-toluenesulfonic acid salt of niraparib.
    Type: Grant
    Filed: April 5, 2021
    Date of Patent: December 13, 2022
    Assignee: Macfarlan Smith Limited
    Inventor: Padmini Kavuru
  • Morphinone reductase for the preparation of hydromorphone and hydrocodone
    Patent number: 5571685
    Abstract: A morphinone reductase enzyme and related process provide for the preparation of hydromorphone from morphinone and hydrocodone from neopinone or codeinone. The enzyme has no significant activity with compounds of similar ring structure, has a molecular weight of approximately 81 kilodaltons and is composed of two identical subunits. The enzyme uses NADH as a cofactor and displays no significant enzymatic activity in the reverse direction.
    Type: Grant
    Filed: November 30, 1994
    Date of Patent: November 5, 1996
    Assignee: MacFarlan Smith Limited
    Inventors: Anne M. Hailes, Christopher E. French, Neil C. Bruce
  • Dehydrohalogenation of a 7-halodihydrocodeinone dialkyl ketal
    Patent number: 4025520
    Abstract: A process for the dehydrohalogenation of a 7-halo- or a 1,7-dihalodihydrocodeinone dialkyl ketal of the general formula (I): ##STR1## in which R represents an alkyl group containing from 1 to 6 carbon atoms, X represents hydrogen or chlorine or bromine and Y represents chlorine or bromine which comprises subjecting the ketal to the action of a base in the presence of a polar aprotic solvent. The process has utility in facilitating the production of codeine.
    Type: Grant
    Filed: March 28, 1975
    Date of Patent: May 24, 1977
    Assignee: Macfarlan Smith Limited
    Inventors: Edward Leon Grew, Nigel David Vaughan Wilson