Patents Assigned to MacKay Medical Foundation The Presbyterian Church
  • Intraluminal therapy system for gastrointestinal infections
    Patent number: 11110209
    Abstract: A novel intraluminal therapy system for providing a quick and effective way to treat gastrointestinal infections. The invention includes a brand new system of treating Helicobacter pylori infections and an agent dispenser for an endoscope apparatus, comprising a pump, a catheter connected to the pump and a nozzle connected to the catheter. The devices are used along with a complex of antibiotic and/or antimicrobial agents to eradicate Helicobacter pylori while performing an endoscopic procedure.
    Type: Grant
    Filed: January 18, 2018
    Date of Patent: September 7, 2021
    Assignee: MACKAY MEDICAL FOUNDATION THE PRESBYTERIAN CHURCH IN TAIWAN MACKAY MEMORIAL HOSPITAL
    Inventor: Tai-Cherng Liou
  • BENZO-HETEROCYCLIC COMPOUNDS AND THEIR APPLICATIONS
    Publication number: 20200339557
    Abstract: The present invention relates to benzoxazole derivatives having the following Formula (I): The compounds of the present invention are found to possess the ability to decrease PD-L1 level, suggesting that the compounds of the invention can be used in cancer immunotherapy and treatment or prevention of sepsis or septic shock.
    Type: Application
    Filed: July 9, 2020
    Publication date: October 29, 2020
    Applicant: MACKAY MEDICAL FOUNDATION THE PRESBYTERIAN CHURCH IN TAIWAN MACKAY MEMORIAL HOSPITAL
    Inventors: Yen-Ta LU, Tzenge-Lien SHIH, Chia-Ming CHANG, Tsai-Yin WEI, Jen-Wei LIU
  • ANTIBODIES AGAINST IMMUNOGENIC GLYCOPEPTIDES, COMPOSITIONS COMPRISING THE SAME AND USE THEREOF
    Publication number: 20180371103
    Abstract: Disclosed herein are antibodies which specifically bind to at least one epitope defined by the immunogenic glycopeptide. Other aspects of the present disclosure are pharmaceutical composition comprising the antibody; and method for preventing and/or treating Globo-H-positive cancer.
    Type: Application
    Filed: March 15, 2018
    Publication date: December 27, 2018
    Applicant: Mackay Medical Foundation The Presbyterian Church In Taiwan Mackay Memorial Hospital
    Inventors: Chih-long CHANG, Chao-chih WU
  • METHODS AND ANTIBODIES FOR MODULATION OF IMMUNORESPONSE
    Publication number: 20180362651
    Abstract: A method fits reversing immune suppression or immune exhaustion or for treating a disease associated with immune suppression includes: administering a co position to a subject in need of such treatments wherein the composition contains a CD11b modulator that binds specifically to CD11b on a cell to inhibit PD-L1 expression. The CD11b modulator is an antibody or an antigen-binding portion thereof, or a compound as described.
    Type: Application
    Filed: June 12, 2016
    Publication date: December 20, 2018
    Applicant: Mackay Medical Foundation The Presbyterian Church In Taiwan Mackay Memorial Hospital
    Inventors: Yen-Ta LU, Chia-Ming CHANG, Tsai-Yin WEI, I-Fang TSAI, Ling-Chiao WU
  • METHODS AND POLYPEPTIDES FOR MODULATION OF IMMUNORESPONSE
    Publication number: 20180141991
    Abstract: A method for modulating an immunoresponse includes binding a TREM-like transcript 1 (TLT-1) polypeptide to an immune cell, wherein the binding of the TLT-1 polypeptide to the immune cell suppresses immunoresponse. A method for treating and/or preventing a disease associated with immune hyper-reactivity includes administering the TLT-1 polypeptide to a subject in need thereof.
    Type: Application
    Filed: June 12, 2016
    Publication date: May 24, 2018
    Applicant: Mackay Medical Foundation The Presbyterian Church In Taiwan Mackay Memorial Hospital
    Inventors: Yen-Ta LU, Chia-Ming CHANG, Tsai-Yin WEI
  • Antibodies against immunogenic glycopeptides, compositions comprising the same and use thereof
    Patent number: 9951143
    Abstract: Disclosed herein are antibodies which specifically bind to at least one epitope defined by the immunogenic glycopeptide. Other aspects of the present disclosure are pharmaceutical composition comprising the antibody; and method for preventing and/or treating Globo-H-positive cancer.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: April 24, 2018
    Assignee: Mackay Medical Foundation The Presbyterian Church In Taiwan Mackay Memorial Hospital
    Inventors: Chih-long Chang, Chao-chih Wu
  • Aurantiamide dipeptide derivatives for treatment or prevention of angiogenesis-related diseases
    Patent number: 9872882
    Abstract: The invention relates to a use of an aurantiamide dipepetide derivative in the treatment or prevention of angiogenesis-related diseases. Accordingly, aurantiamide dipeptide derivatives can be used as angiogenesis inhibitor, whereby preventing or treating invasive and metastatic cancer and ocular neovascularization (particularly macular degeneration such as pathological neovascularization of age-related macular degeneration (AMD)).
    Type: Grant
    Filed: December 28, 2015
    Date of Patent: January 23, 2018
    Assignees: MACKAY MEDICAL COLLEGE, MACKAY MEDICAL FOUNDATION THE PRESBYTERIAN CHURCH IN TAIWAN MACKAY MEMORIAL HOSPITAL, CHANG GUNG UNIVERSITY
    Inventors: Hung-I Yeh, Shih-Wei Wang, Ching-Hu Chung, Pei-Wen Hsieh
  • ANTIBODIES AGAINST IMMUNOGENIC GLYCOPEPTIDES, COMPOSITIONS COMPRISING THE SAME AND USE THEREOF
    Publication number: 20170362337
    Abstract: Disclosed herein are antibodies which specifically bind to at least one epitope defined by the immunogenic glycopeptide. Other aspects of the present disclosure are pharmaceutical composition comprising the antibody; and method for preventing and/or treating Globo-H-positive cancer.
    Type: Application
    Filed: July 20, 2017
    Publication date: December 21, 2017
    Applicant: Mackay Medical Foundation The Presbyterian Church In Taiwan Mackay Memorial Hospital
    Inventors: Chih-long CHANG, Chao-chih WU
  • Antibodies against immunogenic glycopeptides, compositions comprising the same and use thereof
    Patent number: 9828436
    Abstract: Disclosed herein are antibodies which specifically bind to at least one epitope defined by the immunogenic glycopeptide. Other aspects of the present disclosure are pharmaceutical composition comprising the antibody; and method for preventing and/or treating Globo-H-positive cancer.
    Type: Grant
    Filed: March 19, 2015
    Date of Patent: November 28, 2017
    Assignee: MacKay Medical Foundation The Presbyterian Church In Taiwan MacKay Memorial Hospital
    Inventors: Chih-long Chang, Chao-chih Wu
  • IMMUNOGENIC GLYCOPEPTIDES, COMPOSITION COMPRISING THE GLYCOPEPTIDES AND USE THEREOF
    Publication number: 20170143810
    Abstract: Disclosed herein are an immunogenic glycopeptide for inducing immune response to treat cancer. Other aspects of the present disclosure are pharmaceutical composition comprising the immunogenic glycopeptide; and method for preventing and/or treating a cancer.
    Type: Application
    Filed: March 19, 2015
    Publication date: May 25, 2017
    Applicant: MacKay Medical Foundation The Presbyterian Church In Taiwan MacKay Memorial Hospital
    Inventors: Chih-long CHANG, Chao-Chih WU
  • ANTIBODIES AGAINST IMMUNOGENIC GLYCOPEPTIDES, COMPOSITIONS COMPRISING THE SAME AND USE THEREOF
    Publication number: 20170107297
    Abstract: Disclosed herein are antibodies which specifically bind to at least one epitope defined by the immunogenic glycopeptide. Other aspects of the present disclosure are pharmaceutical composition comprising the antibody; and method for preventing and/or treating Globo-H-positive cancer.
    Type: Application
    Filed: March 19, 2015
    Publication date: April 20, 2017
    Applicant: MacKay Medical Foundation The Presbyterian Church
    Inventors: Chih-long CHANG, Chao-chih WU