Abstract: A filtration unit to selectively remove leukocytes from fluids containing platelets and systems including a filtration unit are provided. In one embodiment, a filtration unit is provided including an outer casing enclosing a porous element which includes a leukocyte-removal medium with a coating. The coating includes a polymer containing a main hydrophobic chain and a hydrophilic poly(ethylene oxide) side chain and having a mass average molar mass in the range of from about 1,000 g/mol to about 20,000 g/mol. The hydrophilic poly(ethylene oxide) side chain includes from 9 to 50 ethylene oxide units, and the mass percentage of the poly(ethylene oxide) side chain is less than about 50% of the mass average molar mass of the polymer.

Abstract: The disclosure relates to a centrifuge with a balancing mechanism and method of balancing such a centrifuge. The centrifuge includes a vertical shaft driven in rotation by a motor, and a mechanism for balancing the parts integral with said vertical shaft. The mechanism includes a plate integral with the vertical shaft, at least one compensating mass freely displacing on the plate, the mass being designed to limit the imbalance of parts integral with the vertical shaft, and a mechanism for blocking the compensating mass, the blocking mechanism being designed to immobilize the compensating mass on the plate when the rotation speed exceeds a determined value.

Abstract: Methods for the synthesis of psoralen derivatives are provided.

Abstract: A filtering unit for removing a virucidal substance from a biological fluid including an outer casing having at least one input aperture and at least one output aperture. The outer casing including a filter medium, which separates the filtration unit into an input compartment and an output compartment. The filter medium includes at least one hydrophilic material able to absorb or adsorb the virucidal substance. The at least one hydrophilic material includes either porous non-woven material or a porous membrane.

Abstract: Methods for modifying the physical, chemical and/or biological properties of a fluid by irradiation are provided. In one embodiment, a method comprising supplying a flow of a fluid to an irradiation chamber; focusing the flow of the fluid so as to create at least one fluid layer; and applying radiation to the fluid layer in a defined portion of the irradiation chamber thereby modifying at least one physical, chemical or biological property of the fluid layer is provided. Systems for the implementation of such methods are also provided.

Abstract: The invention includes a bag system for collecting a biological fluid, in particular blood. The system includes a device for collecting the fluid which is in fluid communication with at least one fluid collection bag, and a device for sampling the fluid to be collected which includes at least one sampling receptacle. The sampling device includes a device for transferring the fluid from the bag system into the sampling receptacle or receptacles, in which the transfer device is provided with a device for associating the receptacle or receptacles. The transfer device may be arranged to allow the support of the receptacle or receptacles in a standby position, the guidance of the receptacle or receptacles to a transfer position and, after transfer, the dissociation of the receptacle or receptacles from the bag system.

Abstract: The invention concerns a method of collecting a biological fluid, in particular blood, with an anticoagulant and/or preservation solution added, in which the biological fluid is collected by natural flow and the anticoagulant and/or preservation solution is added by pumping, the method making provision for measuring the flow of fluid collected and slaving the pumping speed to the measured flow, so as to obtain continuously during collection a given ratio between the quantity of fluid collected and the quantity of anticoagulant and/or preservation solution added. The invention also concerns a collection machine and bag system for implementing the method.

Abstract: A biological fluid collection system including a collecting device, a collecting container, a first channel connecting the two, a sampling bag, a second channel connecting the sampling bag and the first tube and at least one substantially irreversible closure device in an open position on at least the first or second channel. The biological fluid may be blood. A method of collecting biological fluid such as blood using the system so that fluid in the sampling bag is substantially irreversibly prevented from entering the collecting container.

Abstract: The invention includes a bag system for collecting a biological fluid, in particular blood. The system includes a device for collecting the fluid which is in fluid communication with at least one fluid collection bag, and a device for sampling the fluid to be collected which includes at least one sampling receptacle. The sampling device includes a device for transferring the fluid from the bag system into the sampling receptacle or receptacles, in which the transfer device is provided with a device for associating the receptacle or receptacles. The transfer device may be arranged to allow the support of the receptacle or receptacles in a standby position, the guidance of the receptacle or receptacles to a transfer position and, after transfer, the dissociation of the receptacle or receptacles from the bag system.

Abstract: The invention includes a bag system for collecting a biological fluid, in particular blood. The system includes a device for collecting the fluid which is in fluid communication with at least one fluid collection bag, and a device for sampling the fluid to be collected which includes at least one sampling receptacle. The sampling device includes a device for transferring the fluid from the bag system into the sampling receptacle or receptacles, in which the transfer device is provided with a device for associating the receptacle or receptacles. The transfer device may be arranged to allow the support of the receptacle or receptacles in a standby position, the guidance of the receptacle or receptacles to a transfer position and, after transfer, the dissociation of the receptacle or receptacles from the bag system.

Abstract: The invention concerns a bag system for collecting a biological fluid the system intended for use in a collection machine including a peristaltic pump, the system including, in closed circuit, a fluid collection device, a solution bag containing an anticoagulant and/or preservation solution, and a collection bag intended to receive the fluid collected with the anticoagulant and/or preservation solution added. The collection bag is in fluid communication with the collection device by way of a first tube provided with a connector and with the solution bag by way of a second tube connected to the connector. A device for associating the first and second tubes is provided to allow, between the connector and the association device, the formation of a loop with the second tube, the conformation of the loop being arranged to enable it to be disposed around at least part of a head of a peristaltic pump.

Abstract: An extraction device for a biological fluid with an additive solution in which it is desirable for the additive solution to be present in a particular volume proportion to the biological fluid. The volume proportion of the additive solution is determined by the ratio of cross sections of two tubes, one which supplies the biological fluid to a collecting bag and a second which supplies the additive solution to a collecting bag. The tubes are periodically constricted in constriction areas by a pump. The tubes are configured so that the additive solution and the biological fluid only mix downstream of the constriction areas, thereby reducing the risk of supplying the additive solution to the source of the biological fluid. In an exemplary embodiment the biological fluid is blood collected from a patient or donor and the additive solution is an anticoagulant and/or preservation solution.

Abstract: A biological fluid collection system including a collecting device, a collecting container, a first channel connecting the two, a sampling bag, a second channel connecting the sampling bag and the first tube and at least one substantially irreversible closure device in an open position on at least the first or second channel. The biological fluid may be blood. A method of collecting biological fluid such as blood using the system so that fluid in the sampling bag is substantially irreversibly prevented from entering the collecting container.

Abstract: A bag system for the collection and sampling of a biological fluid such as blood is described. The system may include a fluid collection bag and a first tube connected on one end to a collection means and on the other end to the collecting bag. It may also include a flexible sampling bag defining an internal volume having a bottom side and an introduction side which is opposite to the bottom and has an inlet orifice. The system also has a second tube, a first end part of which is connected to the first tube and a second end part of which is inserted in the inlet orifice of the sampling bag, so as to extend inside the sampling bag over a distance of between 25% and 60% of the distance between the bottom and the introduction side of the internal volume of the sampling bag.

Abstract: The invention includes a filtration unit for the selective deleukocytation of a fluid containing blood platelets such as blood or a blood component. The unit includes a medium for deleukocytation by adsorption and/or filtration of the leukocytes. The medium is formed by at least one layer of non-woven polyurethane fabric which has been treated by gas plasma. The invention also includes bag systems containing such a unit, including closed filtration systems.

Abstract: The invention relates to a placental blood collection line including a collection bag (1) in fluid communication with at least one collection needle (4, 5) via a first tube (2) associated with an inlet orifice (3) of the bag (1), said line further including a bag (6) containing a rinsing solution and which is connected to or is organized to be connected to said first tube (2) via a second tube (7). The invention also relates to a method of collecting placental 10 blood by using such a line.

Abstract: A filtering unit, which may be used to filter blood or blood components to remove leukocytes. The filtering unit includes a rigid outer casing connected to a filter medium by an impermeable association means to define two compartments. The association means may be flexible and may be disposed around the filter medium. The filtering unit may additionally include a pre-filter and a post-filter.

Abstract: The disclosure includes a flexible bag (1) intended to receive a biological fluid with a view to its centrifugation. The bag includes an external enclosure (2) formed by two sheets of flexible plastic (3, 3?) connected at their periphery (4) so as to define an internal volume (5) for the fluid. The external enclosure (2) is provided with at least one inlet (6) and/or outlet (7) orifice for the fluid. The bag (1) also includes means (8) for the temporary association of at least one component with the bag (1). The means (8) is disposed on the external enclosure (2), in which the temporary association means are assembled on the bag (1) on a part of the periphery (4) of the enclosure (2) and are arranged to allow the insertion of the component between the means (8) and the enclosure (2) so as to provide temporary association during the centrifugation of the bag (1).

Abstract: The invention relates to a method and apparatus for the automatic handling of bag systems in an installation. The method includes the steps of loading at least one bag system having a primary bag containing a body fluid such as blood and a secondary bag into a handling device, wherein the bag system is placed in a position such that no filtering of the body fluid takes place; automatically actuating the handling device so that the bag system is moved to a position wherein filtering occurs; and unloading the bag system from in the handling device when all the filtrate is received in the secondary bag.

Abstract: A bag system for the collection and sampling of a biological fluid such as blood is described. The system may include a fluid collection bag and a first tube connected on one end to a collection means and on the other end to the collecting bag. It may also include a flexible sampling bag defining an internal volume having a bottom side and an introduction side which is opposite to the bottom and has an inlet orifice. The system also has a second tube, a first end part of which is connected to the first tube and a second end part of which is inserted in the inlet orifice of the sampling bag, so as to extend inside the sampling bag over a distance of between 25% and 60% of the distance between the bottom and the introduction side of the internal volume of the sampling bag.