Patents Assigned to Macrophi, Inc.
  • Publication number: 20220372536
    Abstract: An object of the present invention is to provide a lipopolysaccharide production method that contributes to labor hygiene and environmental conservation and is suited for large-scale production and a lipopolysaccharide produced thereby. The present invention relates to a lipopolysaccharide production method, etc., with which a lipopolysaccharide is extracted and purified from gram-negative bacterium and is a lipopolysaccharide production method that includes a first step of performing extraction from the gram-negative bacterium using hot water to obtain an extract liquid that contains the lipopolysaccharide and a second step of purifying the extract liquid or a solution containing the LPS in the extract liquid by using reverse-phase liquid chromatography to obtain the lipopolysaccharide and in that a reverse-phase column used in the reverse-phase liquid chromatography has a packing material constituted of a material having a functional group of 1 to 8 carbons.
    Type: Application
    Filed: September 17, 2020
    Publication date: November 24, 2022
    Applicants: BioMedical Research Group Inc., Macrophi Inc.
    Inventors: Gen-Ichiro Soma, Hiroyuki Inagawa, Chie Kohchi, Kyohei Matsushita, Ryo Hashino, Wenjing Li
  • Patent number: 11278564
    Abstract: A readily-available brain function-improving agent or food composition having an A? intracerebral deposition suppressing effect or a learning function-improving effect is provided based on finding, as a result of orally administering Pantoea LPS to Alzheimer's disease model mice and studying the effects, that oral administration of Pantoea LPS significantly decreased intracerebral A? peptide accumulation and improved learning function.
    Type: Grant
    Filed: December 4, 2017
    Date of Patent: March 22, 2022
    Assignees: Control of Innate Immunity Technology Research Association, National University Corporation Kagawa University, BioMedical Research Group Inc., Macrophi Inc.
    Inventors: Gen-Ichiro Soma, Hiroyuki Inagawa, Chie Kohchi, Yutaro Kobayashi
  • Patent number: 8471001
    Abstract: It has been found that a limulus-positive glycolipid is present in xanthan gum derived from Xanthomonas, which has been commercially available and eaten for many years, and this was purified, and it has been found that this limulus-positive glycolipid has an immunopotentiation effect. A method for safely and inexpensively producing the limulus-positive glycolipid containing an immunopotentiator at high concentrations is provided. The method for producing the limulus-positive glycolipid of the present invention comprises extracting the limulus-positive glycolipid from xanthan gum. A limulus-positive glycolipid composition containing the limulus-positive glycolipid can be used for various applications such as pharmaceuticals, pharmaceuticals for animals, quasi drugs, cosmetics, foods, functional foods, feedstuff and bath agents.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: June 25, 2013
    Assignees: BioMedical Research Group Inc., Macrophi, Inc.
    Inventors: Gen-Ichiro Soma, Chie Kohchi, Hiroyuki Inagawa, Takashi Nishizawa
  • Publication number: 20120046459
    Abstract: It has been found that a limulus-positive glycolipid is present in xanthan gum derived from Xanthomonas, which has been commercially available and eaten for many years, and this was purified, and it has been found that this limulus-positive glycolipid has an immunopotentiation effect. A method for safely and inexpensively producing the limulus-positive glycolipid containing an immunopotentiator at high concentrations is provided. The method for producing the limulus-positive glycolipid of the present invention comprises extracting the limulus-positive glycolipid from xanthan gum. A limulus-positive glycolipid composition containing the limulus-positive glycolipid can be used for various applications such as pharmaceuticals, pharmaceuticals for animals, quasi drugs, cosmetics, foods, functional foods, feedstuff and bath agents.
    Type: Application
    Filed: November 2, 2011
    Publication date: February 23, 2012
    Applicants: Soma, Gen-Ichiro, Macrophi, Inc., BioMedical Research Group Inc.
    Inventors: Gen-Ichiro Soma, Chie Kohchi, Hiroyuki Inagawa, Takashi Nishizawa
  • Patent number: 8071758
    Abstract: It has been found that a limulus-positive glycolipid is present in xanthan gum derived from Xanthomonas, which has been commercially available and eaten for many years, and this was purified, and it has been found that this limulus-positive glycolipid has an immunopotentiation effect. A method for safely and inexpensively producing the limulus-positive glycolipid containing an immunopotentiator at high concentrations is provided. The method for producing the limulus-positive glycolipid of the present invention comprises extracting the limulus-positive glycolipid from xanthan gum. A limulus-positive glycolipid composition containing the limulus-positive glycolipid can be used for various applications such as pharmaceuticals, pharmaceuticals for animals, quasi drugs, cosmetics, foods, functional foods, feedstuff and bath agents.
    Type: Grant
    Filed: February 28, 2007
    Date of Patent: December 6, 2011
    Assignees: BioMedical Research Group Inc., Macrophi, Inc.
    Inventors: Gen-Ichiro Soma, Chie Kohchi, Hiroyuki Inagawa, Takashi Nishizawa
  • Publication number: 20100016577
    Abstract: It has been found that a limulus-positive glycolipid is present in xanthan gum derived from Xanthomonas, which has been commercially available and eaten for many years, and this was purified, and it has been found that this limulus-positive glycolipid has an immunopotentiation effect. A method for safely and inexpensively producing the limulus-positive glycolipid containing an immunopotentiator at high concentrations is provided. The method for producing the limulus-positive glycolipid of the present invention comprises extracting the limulus-positive glycolipid from xanthan gum. A limulus-positive glycolipid composition containing the limulus-positive glycolipid can be used for various applications such as pharmaceuticals, pharmaceuticals for animals, quasi drugs, cosmetics, foods, functional foods, feedstuff and bath agents.
    Type: Application
    Filed: February 28, 2007
    Publication date: January 21, 2010
    Applicants: Soma, Gen-Ichiro, BioMedical Research Group Inc., Macrophi, Inc.
    Inventors: Gen-Ichiro Soma, Chie Kohchi, Hiroyuki Inagawa, Takashi Nishizawa