Patents Assigned to Maddon Advisore LLC
  • ACE2-Targeted Compositions and Methods for Treating COVID-19
    Publication number: 20240409659
    Abstract: This invention provides a monoclonal antibody that (i) specifically binds to the extracellular portion of human angiotensin converting enzyme 2 (hACE2); (ii) specifically inhibits binding of SARS-CoV-2 to the extracellular portion of hACE2; and (iii) does not significantly inhibit the ability of hACE2 to cleave angiotensin II and/or a synthetic MCA-based peptide. This invention also provides related recombinant AAV vectors, recombinant AAV particles, compositions, prophylactic and therapeutic methods, and kits.
    Type: Application
    Filed: October 11, 2022
    Publication date: December 12, 2024
    Applicant: Maddon Advisore LLC
    Inventor: Paul J. Maddon