Abstract: The present application relates to computer-based preoperative planning technology, and discloses a preoperative planning method for multimodal ablation treatment and apparatus thereof, which can automatically provide objective, scientific, and quantitative multimodal ablation planning information. In this method, acquiring parameters of an volume to be ablated; calculating property changes of the tissue caused by performing freezing on the volume according to the parameters of the volume to be ablated, and acquiring a first planning data required for the property changes of the tissue to satisfy a first predetermined condition; further calculating property changes of the tissue caused by performing heating on the volume to acquire a second planning data required for the property changes of the tissue to satisfy a second predetermined condition based on the properties satisfying the first predetermined condition; outputting the first planning data and the second planning data.

Abstract: Provided are a tumour immunogen, a preparation method therefore, and an application. After localised sequential cooling-heating treatment is performed on tumour tissue and/or cells, the tumour tissue and/or cells release a large amount of tumour immunogen heat shock protein 70. The obtained tumour immunogen can activate the body's tumour immune system, to convert immunosuppressive cells into mature dendritic cells, thereby increasing immunogen presentation, and activating tumour immunity.