Patents Assigned to Mahidol University
  • Patent number: 10335478
    Abstract: Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural viral proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: July 2, 2019
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Mahidol University
    Inventors: Richard M. Kinney, Claire Y. H. Kinney, Siritorn Butrapet, Duane J. Gubler, Natth Bhamarapravati
  • Patent number: 9557341
    Abstract: The present invention provides a method of predicting the risk of a patient for developing cutaneous adverse drug reaction to non-nucleoside reverse transcriptase inhibitors such as nevirapine by using HLA-B*3505 allele and/or polymorphisms in the CCHCR1 gene.
    Type: Grant
    Filed: December 11, 2009
    Date of Patent: January 31, 2017
    Assignees: MAHIDOL UNIVERSITY, RIKEN, DEPARTMENT OF MEDICAL SCIENCES, MINISTRY OF PUBLIC, THAILAND CENTER OF EXCELLENCE FOR LIFE SCIENCES (OKMD)
    Inventors: Somnuek Sungkanuparph, Sasisopin Kiertiburanakul, Thanyachai Sura, Wasun Chantratita, Soranun Chantarangsu, Angkana Charoenyingwattana, Surakameth Mahasirimongkol, Michiaki Kubo, Taisei Mushiroda, Yusuke Nakamura
  • Publication number: 20160367658
    Abstract: Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural viral proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
    Type: Application
    Filed: September 6, 2016
    Publication date: December 22, 2016
    Applicants: The Government of the USA, as represented by the Secretary, Department of Health and Human Services, Mahidol University
    Inventors: Richard M. Kinney, Claire Y.H. Kinney, Siritorn Butrapet, Duane J. Gubler, Natth Bhamarapravati
  • Patent number: 9463233
    Abstract: Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural viral proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
    Type: Grant
    Filed: January 28, 2014
    Date of Patent: October 11, 2016
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Mahidol University
    Inventors: Richard M. Kinney, Claire Y. H. Kinney, Siritorn Butrapet, Duane J. Gubler, Natth Bhamarapravati
  • Publication number: 20140141040
    Abstract: Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural viral proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
    Type: Application
    Filed: January 28, 2014
    Publication date: May 22, 2014
    Applicants: Mahidol University, The Government of the USA, as represented by the Secretary, Department of Health and Human Services
    Inventors: Richard M. Kinney, Claire Y.H. Kinney, Siritorn Butrapet, Duane J. Gubler, Natth Bhamarapravati
  • Patent number: 8673316
    Abstract: Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural viral proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
    Type: Grant
    Filed: August 18, 2011
    Date of Patent: March 18, 2014
    Assignees: The United States of America, as represented by the Secretary, Department of Health and Human Services, Centers for Disease Control and Prevention, Mahidol University
    Inventors: Richard M. Kinney, Claire Y. H. Kinney, Duane J. Gubler, Siritorn Butrapet, Natth Bhamarapravati
  • Publication number: 20120021936
    Abstract: The present invention provides protein-based biomarkers and biomarker combinations that are useful in qualifying dengue status in a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as infected with dengue or not infected with dengue. The biomarkers can be detected by SELDI mass spectrometry.
    Type: Application
    Filed: October 14, 2009
    Publication date: January 26, 2012
    Applicants: Mahidol University, The Royal Institution for the Advancement of Learning/McGill University
    Inventors: Brian Ward, Momar Ndao, Takol Chareonsirisuthikul, Sukathida Ubol
  • Publication number: 20110301043
    Abstract: The present invention provides a method of predicting the risk of a patient for developing cutaneous adverse drug reaction to non-nucleoside reverse transcriptase inhibitors such as nevirapine by using HLA-B*3505 allele and/or polymorphisms in the CCHCR1 gene.
    Type: Application
    Filed: December 11, 2009
    Publication date: December 8, 2011
    Applicants: MAHIDOL UNIVERSITY, RIKEN, DEPARTMENT OF MEDICAL SCIENCES
    Inventors: Somnuek Sungkanuparph, Sasisopin Kiertiburanakul, Thanyachai Sura, Wasun Chantratita, Soranun Chantarangsu, Angkana Charoenyingwattana, Surakameth Mahasirimongkol, Michiaki Kubo, Taisei Mushiroda, Yusuke Nakamura
  • Patent number: 8025887
    Abstract: Chimeric flaviviruses that are avirulent and immunogenic are provided. The chimeric viruses are constructed to contain amino acid mutations in the nonstructural viral proteins of a flavivirus. Chimeric viruses containing the attenuation-mutated nonstructural genes of the virus are used as a backbone into which the structural genes of a second flavivirus strain are inserted. These chimeric viruses elicit pronounced immunogenicity yet lack the accompanying clinical symptoms of viral disease. The attenuated chimeric viruses are effective as immunogens or vaccines and may be combined in a pharmaceutical composition to confer simultaneous immunity against several strains of pathogenic flaviviruses.
    Type: Grant
    Filed: October 28, 2009
    Date of Patent: September 27, 2011
    Assignees: The United States of America as represented by the Department of Health and Human Services, Centers for Disease Control and Prevention, Mahidol University
    Inventors: Richard M. Kinney, Claire Y. H. Kinney, Duane J. Gubler, Siritorn Butrapet, Natth Bhamarapravati
  • Patent number: 7629117
    Abstract: The present specification discloses methods of determining risk of developing Dengue Hemorrhagic Fever/Dengue Shock Syndrome (DHF/DSS) in an individual infected with dengue virus (DV). The methods comprise determining, in a fluid or tissue sample of an individual, the presence, absence or quantity of dengue virus protein NS1, and determining, in a fluid or tissue sample of the individual, presence, absence or quantity of SC5b-9 complement complex. The methods can further comprise comparing the levels of NS1 protein and SC5b-9 complement complex with a database comprising epidemiological data correlating levels of NS1 protein and SC5b-9 complement complex with probability of developing DHF/DSS in a population.
    Type: Grant
    Filed: June 15, 2007
    Date of Patent: December 8, 2009
    Assignee: Mahidol University
    Inventors: Panisadee Avirutnan, Prida Malasit, Sucharit Bhakdi Punyaratabhandu, Watchara Kasinrerk, Chunya Pauttikhunt
  • Patent number: 7135164
    Abstract: A composition in the form of a biodegradable gel, chip or ointment is provided, for adjunct treatment of periodontitis, comprising: (i) an antimicrobial extract having antimicrobial or antibacterial activity against periodontal pathogens, preferably from one or more of the plants Andrographis paniculata, mangosteen (Garcinia mangostana) and turmeric (Curcuma longa); and (ii) a gel base containing a mixture of glyceryl monooleate and triglyceride. The composition is biodegradable, and forms a liquid crystal structure on contacting gingival fluid, which liquid crystal structure releases active ingredients gradually, to provide a sustained release dosage form.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: November 14, 2006
    Assignee: Mahidol University
    Inventors: Pleumchitt Rojanapanthu, Wandee Gritsanapan, Mullika Sirirat, Cholticha Amornchat
  • Patent number: 7098016
    Abstract: An enzyme is re-engineered to be a zymogen, an enzyme precursor which is converted into an enzyme by protease cleavage. In the example described here, an RNase A enzyme is converted into a zymogen by adding to the enzyme a bridge of amino acids linking the amino and carboxyl termini of the enzyme. The bridge has built in it a protease cleavage site for a specific protease, for example the protease plasmepsin II, produced by the malaria parasite. Since RNase A can be made cytotoxic, this permits a cytotoxic enzyme to be made in the form of a zymogen that becomes active only when it is acted on by a protease only present in a particular target cell such as a pathogen.
    Type: Grant
    Filed: June 13, 2003
    Date of Patent: August 29, 2006
    Assignees: Wisconsin Alumni Research Foundation, Mahidol University
    Inventors: Ronald T. Raines, Parit Plainkum, Stephen M. Fuchs
  • Publication number: 20030091517
    Abstract: A composition in the form of a biodegradable gel, chip or ointment is provided, for adjunct treatment of periodontitis, comprising: (i) an antimicrobial extract having antimicrobial or antibacterial activity against periodontal pathogens, preferably from one or more of the plants Andrographis paniculata, mangosteen (Garcinia mangostana) and turmeric (Curcuma longa); and (ii) a gel base containing a mixture of glyceryl monooleate and triglyceride. The composition is biodegradable, and forms a liquid crystal structure on contacting gingival fluid, which liquid crystal structure releases active ingredients gradually, to provide a sustained release dosage form.
    Type: Application
    Filed: November 8, 2002
    Publication date: May 15, 2003
    Applicant: Mahidol University
    Inventors: Pleumchitt Rojanapanthu, Wandee Gritsanapan, Mullika Sirirat, Cholticha Amornchat