Patents Assigned to Mahmoud H. el Kouni
  • Enzyme inhibitors, their synthesis, and methods for use
    Patent number: 5721241
    Abstract: Novel compounds are provided that are effective to inhibit the activity of DHUDase or UrdPase. Such compounds have the general formula ##STR1## where X is S or Se; Y H is I, F, Cl, Br, methoxy, benzyl, selenenylphenyl, or thiophenyl, and R.sub.1 is H or an acyclo tail having the general formula ##STR2## where R.sub.2 is H, CH.sub.2 OH or CH.sub.2 NH.sub.2 ; R.sub.3 is OH, NH.sub.2, or OCOCH.sub.2 CH.sub.2 CO.sub.2 H; and R.sub.4 is O, S, or CH.sub.2.The compounds can be used in pharmaceutical compositions, along with various chemotherapeutic agents to increase the efficacy of the treatment. These compounds can also be used in methods of treating patients by coadministering or sequentially administering the enzyme inhibiting compounds with a chemotherapeutic agent effective to treat cancers, or viral, fungal, bacterial, or parasitic infections. The compounds have further utility in enhancing imaging.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: February 24, 1998
    Assignees: Mahmoud H. el Kouni, Fardos N. M. Naguib, Raymond F. Schinazi
    Inventors: Mahmoud H. el Kouni, Fardos N. M. Naguib, Raymond F. Schinazi
  • Enzyme inhibitors, their synthesis and methods for use
    Patent number: 5476855
    Abstract: Novel compounds are provided that are effective to inhibit the activity of DHUDase or UrdPase. Such compounds have the general formula ##STR1## where X is S or Se; Y is I, F, Cl, Br, methoxy, benzyl, selenenylphenyl, or thiophenyl, and R.sub.1 is an acyclo tail having the general formula ##STR2## where R.sub.2 is H, CH.sub.2 OH or CH.sub.2 NH.sub.2 ; R.sub.3 is OH, NH.sub.2, or OCOCH.sub.2 CH.sub.2 CO.sub.2 H; and R.sub.4 is O, S, or CH.sub.2.The compounds can be used in pharmaceutical compositions, along with various chemotherapeutic agents to increase the efficacy of the treatment. These compounds can also be used in methods of treating patients by coadministering or sequentially administering the enzyme inhibiting compounds with a chemotherapeutic agent effective to treat cancers, or viral, fungal, bacterial, or parasitic infections. The compounds have further utility in enhancing imaging.
    Type: Grant
    Filed: November 2, 1993
    Date of Patent: December 19, 1995
    Assignees: Mahmoud H. el Kouni, Fardos N. M. Naguib, F. Schinazi
    Inventors: Mahmoud el Kouni, Fardos N. M. Naguib, Raymond F. Schinazi