Abstract: This invention relates to the regulation of FGF-1 export. In addition, this invention provides methods of regulating the export of FGF-1 from the cell membrane, which methods include regulating the Syn-1 molecule to affect the formation of the FGF-1:Syn-1 complex, regulating the enzyme or protease which cleaves Syn-1 in the FGF-1:Syn-1 complex to effect the release of FGF-1 from the cell membrane, or regulating the FGF-1:Syn-1 complex itself at or near the cell membrane. The invention also provides compositions related to the regulation of FGF-1 export.
Type:
Application
Filed:
January 29, 2003
Publication date:
February 12, 2004
Applicant:
Maine Medical Research Center
Inventors:
Thomas Maciag, Wilson H. Burgess, Francesca Tarantini, Susan Gamble, Anthony Q. Jackson, Brian Hampton