Abstract: The present invention provides microspheres intended to be administered by injection comprising a protein active ingredient and an agent coating the active ingredient intended to prolong its release, wherein they are free of any trace of organic solvent and they can be obtained according to a coating method involving bringing the active ingredient and the coating agent into contact, with stirring, in a supercritical fluid, said coating agent being soluble in this supercritical fluid.

Abstract: The invention relates to a filament comprising thermoluminescent particles that are evenly distributed in a polymer matrix, characterized in that the polymer matrix is a thermoplastic polymer having sufficient adhesion with respect to said thermoluminescent particles in order to ensure the cohesion of said filament and being such that the thermoluminescent response (signal) of the filament corresponds substantially to the dose of radiation absorbed and obtained after the filament is placed in contact with a physiological medium. The invention also relates to a method for thermoluminescence-based measurement of doses of beta radiation delivered by a transmitter on a target organ of a mammal, characterized in that a group of inventive filaments is introduced to the desired spot, whereby part of the length of said filaments remains outside the irradiated area, and in that the filaments are removed after irradiation and thermoluminescence is determined.