Abstract: The present invention is directed to synthetic molecules having biological activity similar to PIM (acyl glycerol phosphatidylinositol manno-oligosaccharide) activity, for use in the treatment and prevention of inflammatory or immune cell mediated diseases or disorders.
Type:
Grant
Filed:
November 18, 2004
Date of Patent:
August 2, 2011
Assignees:
The Malaghan Institute of Medical Research, University of Otago, Agresearch Limited
Inventors:
Gurmit Singh-Gill, David Samuel Larsen, Jeremy David Jones, Wayne Bruce Severn, Jacquie Lucille Harper, Gavin Painter
Abstract: Compounds of formula (I) or formula (II) have anti-inflammatory activity and comprise a new class of NSAIDs. The compounds are useful for treating inflammatory diseases or disorders. The invention also provides pharmaceutical compositions containing these compounds, as well as methods of treating inflammatory diseases or disorders using compounds of formula (III) or formula (IV).
Type:
Grant
Filed:
September 16, 2005
Date of Patent:
October 5, 2010
Assignees:
New Zealand Institute for Crop & Food Research Limited, National Institute of Water and Atmospheric Research Limited, Malaghan Institute of Medical Research
Inventors:
William Alexander Denny, Brent Raymond Copp, Allison Norrie Pearce, Michael Vivian Berridge, Jacquie Lucille Harper, Nigel Brian Perry, Lesley Larsen, Colette Amirah Godfrey
Abstract: This invention is directed to methods of preventing or reducing the severity of asthma or the risk of development of same in an individual. The method relies on administration to the airways of the individual of an immunologically effective dose of a mycobacterium based vaccine. The mycobacteria are effective in inducing a Th1 type immune response in the individual.
Type:
Application
Filed:
November 7, 2002
Publication date:
July 24, 2003
Applicant:
The Malaghan Institute of Medical Research
Inventors:
Graham Stephen Le Gros, Charles Richard William Beasley, John William Holloway, Klaus Erb
Abstract: This invention is directed to methods of preventing or reducing the severity of asthma or the risk of development of same in an individual. The method relies on administration to the airways of the individual of an immunologically effective dose of a mycobacterium based vaccine. The mycobacteria are effective in inducing a Thl type immune response in the individual.
Type:
Grant
Filed:
October 5, 1998
Date of Patent:
May 27, 2003
Assignee:
The Malaghan Institute of Medical Research
Inventors:
Graham Stephen Le Gros, Charles Richard William Beasley, John William Holloway, Klaus Erb