Abstract: Described herein are X-ray-based CT systems, specifically those with a stationary X-ray source and a moving object of interest, and methods of using the same, that address limitations in current stationary-source CT, such as scatter contamination and limited scan trajectories. The described systems include a pre-object collimator to form a narrow beam. Scatter contamination is reduced to less than 5% of acquired projections, resulting in high-quality CT images with minimal artifacts, improving diagnostic accuracy and measurement precision. The described system also allows for nonplanar trajectories, providing complete sampling of an object along multiple degrees of freedom.