Patents Assigned to Malladi Drugs & Pharmaceuticals Ltd.
  • Thrombolytic enzyme and a process for its preparation
    Patent number: 8835145
    Abstract: The invention relates to a thrombolytic enzyme referred to as Thrombinase having a molecular weight of 31,000 to 32,000. Such a thrombolytic enzyme can be used for dissolving blood clots. The process comprises culturing a filtrate of Bacillus sphaericus sero type H5a 5b, removing the cell, subjecting the cell supernatant to filtration, salting out the retentate, subjecting the precipitate to dialysis, reprecipitating the precipitate and then reconstituting in buffer and finally decolorizing, purifying and dialyzing.
    Type: Grant
    Filed: October 12, 2007
    Date of Patent: September 16, 2014
    Assignees: National Research Development Corporation, India and Malladi Drugs Pharmaceuticals Ltd.
    Inventors: Subrahamanyam Chivukula Sekar, Sundaramurthy Suresh Babu, Sita Mahadevan
  • Process for the preparation of d-threo-ritalinic acid hydrochloride by resolution of dl-threo-ritalinic acid using chiral carboxylic acid
    Patent number: 8552030
    Abstract: The invention disclosed in this application relates to an improved process for the manufacture of d-threo-ritalinic acid hydrochloride and l-threo-ritalinic acid hydrochloride in an optically pure form by the resolution of dl-threo-ritalinic acid using a chiral carboxylic acid The d-threo-ritalinic acid hydrochloride prepared by the process of the present invention on esterification gives d-threo-methylphenidate, a very well known CNS stimulant.
    Type: Grant
    Filed: July 3, 2009
    Date of Patent: October 8, 2013
    Assignee: Malladi Drugs & Pharmaceuticals Ltd.
    Inventors: Tangirala Prakasam, Borkatte Narasimha Hitesh Kumar, Sangu Perumal, Kothandapani Loganathan
  • Thrombolytic enzyme and a process for its preparation
    Patent number: 7776574
    Abstract: The invention relates to a thrombolytic enzyme referred to as Thrombinase having a molecular weight of 31,000 to 32,000. Such a thrombolytic enzyme can be used for dissolving blood clots. The process comprises culturing a filtrate of Bacillus sphaericus sero type H5a 5b, removing the cell, subjecting the cell supernatant to filtration, salting out the retentate, subjecting the precipitate to dialysis, reprecipitating the precipitate and then reconstituting in buffer and finally decolourizing, purifying and dialyzing.
    Type: Grant
    Filed: May 20, 2004
    Date of Patent: August 17, 2010
    Assignees: National Research Development Corporation, Malladi Drugs & Pharmaceuticals Ltd.
    Inventors: Perurmadom Ramaiyer Mahadevan, Sita Mahadevan, legal representative, Subrahmanyam Chivukula Sekar, Sundaramurthy Suresh Babu
  • Novel thrombolytic enzyme and a process for its preparation
    Publication number: 20090285793
    Abstract: The invention relates to a thrombolytic enzyme referred to as Thrombinase having a molecular weight of 31,000 to 32,000. Such a thrombolytic enzyme can be used for dissolving blood clots. The process comprises culturing a filtrate of Bacillus sphaericus sero type H5a 5b, removing the cell, subjecting the cell supernatant to filtration, salting out the retentate, subjecting the precipitate to dialysis, reprecipitating the precipitate and then reconstituting in buffer and finally decolourizing, purifying and dialyzing.
    Type: Application
    Filed: October 12, 2007
    Publication date: November 19, 2009
    Applicants: National Research Development Corporation, Malladi Drugs & Pharmaceuticals Ltd.
    Inventors: Perurmadom Ramaiyer Mahadevan, Sita Mahadevan, Subrahamanyam Chivukula Sekar, Sundaramurthy Suresh Babu
  • Novel thrombolytic enzyme and a process for its preparation
    Publication number: 20050260704
    Abstract: The invention relates to a thrombolytic enzyme referred to as Thrombinase having a molecular weight of 31,000 to 32,000. Such a thrombolytic enzyme can be used for dissolving blood clots. The process comprises culturing a filtrate of Bacillus sphaericus sero type H5a 5b, removing the cell, subjecting the cell supernatant to filtration, salting out the retentate, subjecting the precipitate to dialysis, reprecipitating the precipitate and then reconstituting in buffer and finally decolourizing, purifying and dialyzing.
    Type: Application
    Filed: May 20, 2004
    Publication date: November 24, 2005
    Applicants: National Research Development Corporation, Malladi Drugs & Pharmaceuticals Ltd.
    Inventors: Perurmadom Mahadevan, Sita Mahadevan, Subrahamanyam Sekar, Sundaramurthy Babu