Patents Assigned to Mallinckrodt Inc.
  • Sustained-Release Opiate and Opiate Derivative Compositions
    Publication number: 20110077222
    Abstract: The present invention provides sustained-release opiate compositions. In particular, the present invention provides sustained-release opiate compositions that include an opiate attached to a blood albumin binder. The present invention also relates to methods of administering an opiate with a sustained release pharmacokinetic profile.
    Type: Application
    Filed: September 30, 2010
    Publication date: March 31, 2011
    Applicant: Mallinckrodt Inc.
    Inventors: Carl J. Schaefer, Gary L. Cantrell
  • One-Pot Preparation of Hexahydroisoquinolines from Dihydroisoquinolines
    Publication number: 20110071300
    Abstract: The present invention provides an efficient process for the preparation of hexahydroisoquinolines from dihydroisoquinolines. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines.
    Type: Application
    Filed: September 24, 2010
    Publication date: March 24, 2011
    Applicant: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Frank W. Moser, Peter X. Wang, Gary L. Cantrell, David W. Berberich
  • MEDICAL DEVICE WITH ANTIMICROBIAL LAYER
    Publication number: 20110067703
    Abstract: A medical device includes a conduit for a fluid. The conduit has a wall formed of a hydrophobic polymer with a hydrophilic polymer layer extruded over it, and an antimicrobial substantially dispersed within the hydrophilic polymer. The antimicrobial compound may be a predetermined amount of phosphorus-based glass having a predetermined quantity of a metal such as silver substantially dispersed therein. The medical device may be an endotracheal tube made by providing a hydrophobic polymer, a hydrophilic polymer and an antimicrobial compound, forming the hydrophobic polymer, the hydrophilic polymer and the antimicrobial compound into a conduit, and forming a cuff on an end of the conduit.
    Type: Application
    Filed: December 1, 2010
    Publication date: March 24, 2011
    Applicant: Mallinckrodt Inc.
    Inventors: Paul W. Martens, Robert L. Nieto, Robert Virag, Adin M. Potter
  • Methods for Producing Hydrocodone, Hydromorphone or a Derivative Thereof
    Publication number: 20110071297
    Abstract: The present disclosure generally relates to methods for producing opioid derivatives. More particularly, the present disclosure relates to the preparation of hydromorphone, hydrocodone, or a derivative thereof, by means of a non-catalytic hydrogenation reaction of thebaine, oripavine or a derivative thereof, respectively, using a hydrazide reagent, followed by hydrolysis of the hydrogenated intermediate at a low temperature and for a short period of time. Additionally, the present disclosure relates to a composition comprising the desired hydromorphone, hydrocodone, or a derivative thereof, in combination with a 6-beta compound that is structurally related thereto.
    Type: Application
    Filed: September 20, 2010
    Publication date: March 24, 2011
    Applicant: Mallinckrodt inc.
    Inventors: Brian Orr, William E. Dummitt
  • Heterogeneous Ruthenium Metal Catalyst for the Production of Hydrocodone, Hydromorphone or a Derivative Thereof
    Publication number: 20110071016
    Abstract: The present disclosure generally relates to catalytic methods for producing opioid derivatives. More particularly, the present disclosure relates to the preparation of hydrocodone, hydromorphone, or a derivative thereof, by means of a conversion or an isomerization of codeine, morphine, or a derivative thereof, respectively, using a heterogeneous ruthenium metal catalyst.
    Type: Application
    Filed: September 21, 2010
    Publication date: March 24, 2011
    Applicant: Mallinckrodt Inc.
    Inventor: David E. GINDELBERGER
  • Preparation of 10-Keto Morphinans by Benzylic Oxidation
    Publication number: 20110071296
    Abstract: The present invention provides processes for the preparation of 10-keto and/or 10-hydroxy morphinans. In particular, the invention provides to processes for preparing a 10-keto morphinan by chromium-catalyzed benzylic oxidation of a morphinan with a periodic acid.
    Type: Application
    Filed: September 7, 2010
    Publication date: March 24, 2011
    Applicant: Mallinckrodt Inc.
    Inventors: Hang Sun, John E. Johnson, JR., Ricky L. Fenton, Sarah M. Dorn
  • One-Pot Preparation of Hexahydroisoquinolines from Amides
    Publication number: 20110071299
    Abstract: The present invention provides an efficient process for the preparation of hexahydroisoquinolines from amides. In particular, the invention provides a good yielding, one-pot process for the synthesis of hexahydroisoquinolines.
    Type: Application
    Filed: September 24, 2010
    Publication date: March 24, 2011
    Applicant: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Frank W. Moser, Peter X. Wang, Gary L. Cantrell, David W. Berberich
  • Method and circuit for storing and providing historical physiological data
    Patent number: 7904131
    Abstract: Embodiments of the present invention include systems and methods that relate to pulse oximetry. Specifically, one embodiment includes an oximeter sensor, comprising a light emitting element configured to emit light, a light detector configured to receive the light, and a memory device that stores data, comprising an amount of wetness on the oximeter sensor.
    Type: Grant
    Filed: June 1, 2006
    Date of Patent: March 8, 2011
    Assignee: Mallinckrodt Inc.
    Inventors: Paul D. Mannheimer, Michael E. Fein
  • Bridgehead labelled compounds and methods of using the same
    Patent number: 7901667
    Abstract: The present invention relates to compounds having the general formula: Y-L-BFR-X wherein BFR is a bridged fused ring system; Y is a targeting group; L is optionally present and is a linker for coupling Y to BFR; and X is halogen (e.g., radiohalogen) or a functional group for labelling.
    Type: Grant
    Filed: January 30, 2006
    Date of Patent: March 8, 2011
    Assignee: Mallinckrodt Inc.
    Inventors: Jacobus Donatus M. Herscheid, Joost Verbeek
  • Systems and methods for managing information relating to medical fluids and containers therefor
    Patent number: 7898416
    Abstract: The present invention relates to management of information relating to medical fluids, containers therefore, and medical fluid administration devices for administering such medical fluids to patients. Data tags (e.g., RFID tags) are generally associated with containers of the invention and may be electromagnetically read from and/or written to using an electromagnetic device, for example, that may be associated with a medical fluid administration device of the invention.
    Type: Grant
    Filed: December 29, 2006
    Date of Patent: March 1, 2011
    Assignee: Mallinckrodt Inc.
    Inventors: Frank M. Fago, David W. Wilson, Chad M. Gibson, William E. Bausmith, Vernon D. Ortenzi, Elaine E. Haynes, Elaine F. Borgemenke, John H. Lewis, Gary S. Wagner
  • Thiadiazole compounds and uses thereof
    Patent number: 7888378
    Abstract: Thiadiazole compounds, compositions, bioconjugates, and methods for targeting and photoactivation at target sites.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: February 15, 2011
    Assignee: Mallinckrodt Inc.
    Inventors: Raghavan Rajagopalan, Frederick G. Jacobs, Richard B. Dorshow
  • Method and circuit for storing and providing historical physiological data
    Patent number: 7881761
    Abstract: Embodiments of the present invention relate to a sensor for facilitating detection of a physiological characteristic of a patient. Specifically, one embodiment includes a detector configured to obtain signals from the patient, the signals being indicative of the physiological characteristic, an interface configured to send the signals to a monitor, and a sensor memory coupled with the sensor and separate from the monitor, the sensor memory storing sensor expiration data.
    Type: Grant
    Filed: June 1, 2006
    Date of Patent: February 1, 2011
    Assignee: Mallinckrodt Inc.
    Inventors: Paul D. Mannheimer, Michael E. Fein, Marcia Fein, legal representative
  • (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof
    Publication number: 20110015219
    Abstract: The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as a method for identifying (+)-morphinans that may be therapeutically effective by determining whether the (+)-morphinan inhibits the activation of TLR9. Also provided are methods of using the (+)-morphinans comprising TLR9 antagonist activity to treat conditions such as traumatic pain, neuropathic pain, inflammatory disorders, acetaminophen toxicity, autoimmune disorders, neurodegenerative disorders, and cancer.
    Type: Application
    Filed: July 16, 2010
    Publication date: January 20, 2011
    Applicant: Mallinckrodt Inc.
    Inventors: Bobby N. Trawick, David W. Berberich
  • 3-Oxy-Hydromorphone Derivatives
    Publication number: 20110015398
    Abstract: The present invention provides 3-oxy-hydromorphone derivatives, and in particular, 3-ester, 3-carbonate, and 3-sulfonate derivatives of hydromorphone.
    Type: Application
    Filed: July 9, 2010
    Publication date: January 20, 2011
    Applicant: Mallinckrodt Inc.
    Inventors: Gary L. Cantrell, Robert E. Halvachs, Frank W. Moser, David W. Berberich, Peter X. Wang
  • Method for the Enrichment of Buprenorphine using Chromatographic Techniques
    Publication number: 20110009633
    Abstract: The present invention provides processes for the enrichment of buprenorphine in a product. In particular, the present invention provides processes for the enrichment of buprenorphine in a product using chromatographic techniques.
    Type: Application
    Filed: June 18, 2010
    Publication date: January 13, 2011
    Applicant: Mallinckrodt Inc.
    Inventor: Enrico A. Antonini
  • Systems and methods for managing information relating to medical fluids and containers therefor
    Patent number: 7859473
    Abstract: The present invention relates to management of information relating to medical fluids, containers therefore, and medical fluid administration devices for administering such medical fluids to patients. Data tags (e.g., RFID tags) are generally associated with containers of the invention and may be electromagnetically read from and/or written to using an electromagnetic device, for example, that may be associated with a medical fluid administration device of the invention.
    Type: Grant
    Filed: December 29, 2006
    Date of Patent: December 28, 2010
    Assignee: Mallinckrodt Inc.
    Inventor: Chad M. Gibson
  • Preparation of 6-Alpha-Amino N-Substituted Morphinans by Catalytic Hydrogen Transfer
    Publication number: 20100317683
    Abstract: The present invention provides processes for the stereoselective synthesis of 6-alpha-amino N-substituted morphinans. In particular, the invention provides processes for the reductive amination of 6-keto N-substituted morphinans by catalytic hydrogen transfer.
    Type: Application
    Filed: June 10, 2010
    Publication date: December 16, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Gary L. Cantrell, Joseph P. McClurg, Catherine E. Thomasson, Frank W. Moser
  • Granular Sustained Release Preparation and Production Thereof
    Publication number: 20100316721
    Abstract: There is disclosed a novel sustained release granular resin-pharmaceutical composition comprising an ion exchange resin complexed with a pharmaceutical material wherein said complex is embedded into and on the surface of a diffusion barrier material. There is also disclosed a novel process for preparing the granulated complex wherein an aqueous granulating vehicle is employed to form the complex and the granulated product, thereby avoiding the use of coatings and large amounts of organic solvents in the process.
    Type: Application
    Filed: August 4, 2010
    Publication date: December 16, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Siva N. Raman, John P. Cunningham
  • Remove Amination of 6-Keto Normorphinans by Catalytic Hydrogen Transfer
    Publication number: 20100317861
    Abstract: The present invention provides processes for the stereoselective synthesis of 6-alpha-amino morphinans. In particular, the invention provides processes for the reductive amination of 6-keto normorphinans by catalytic transfer hydrogenation.
    Type: Application
    Filed: June 10, 2010
    Publication date: December 16, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Christopher W. Grote, Gary L. Cantrell, Joseph P. McClurg, Catherine E. Thomasson, Frank W. Moser
  • Solid Phase Peptide for the Production of Goserelin
    Publication number: 20100311946
    Abstract: The present invention provides a process for the production of goserelin. In particular, the process of the invention allows the use of side chain protecting groups during synthesis of the peptide, and the addition of the azaglycine moiety of the peptide.
    Type: Application
    Filed: May 26, 2010
    Publication date: December 9, 2010
    Applicant: Mallinckrodt Inc.
    Inventors: Kripa S. Srivastava, Matthew R. Davis