Patents Assigned to Mallinckrodt LLC
  • Patent number: 10604488
    Abstract: The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhibitor, as well as methods for using the combination compositions to treat pain.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: March 31, 2020
    Assignee: Mallinckrodt LLC
    Inventors: Bobby N. Trawick, David W. Berberich, Christopher W. Grote
  • Publication number: 20200079785
    Abstract: The present invention provides MMC prodrug compounds and liposomal MMC prodrugs and compositions thereof for the treatment of cancer. The compositions include liposomes containing a phosphatidylcholine lipid, a sterol, a PEG-lipid and a MMC prodrug. The present invention also provides liposomal compositions for the treatment of cancer comprising administering to a patient in need thereof a liposome, wherein the liposome comprises: a phosphatidylcholine lipid; a sterol; a PEG-lipid and a MMC prodrug or a pharmaceutically-acceptable salt thereof.
    Type: Application
    Filed: November 8, 2017
    Publication date: March 12, 2020
    Applicant: Mallinckrodt LLC
    Inventors: William McGHEE, Michelle SCHMIDT, Margaret GRAPPERHAUS, Kah Tiong KUAN
  • Patent number: 10383823
    Abstract: The present invention provides a composition for the treatment of cancer including zwitterionic liposomes consisting essentially of: 50-65 mol % of a phosphatidylcholine lipid, 30-45 mol % of cholesterol, and 2-8 mol % of a PEG-lipid; and cisplatin. Cisplatin is encapsulated in the liposomes in an amount such that the ratio of the total lipid weight to the cisplatin weight is from about 65:1 to about 95:1. Methods for the preparation of liposomal cisplatin and the treatment of cancer are also disclosed.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: August 20, 2019
    Assignee: MALLINCKRODT LLC
    Inventor: William McGhee
  • Patent number: 10363251
    Abstract: The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat a variety of disorders.
    Type: Grant
    Filed: July 31, 2015
    Date of Patent: July 30, 2019
    Assignee: Mallinckrodt LLC
    Inventors: Bobby N. Trawick, David W. Berberich, Christopher W. Grote
  • Patent number: 10213385
    Abstract: The present invention provides methods for delivery of therapeutic agents to a subject using multi-component liposomal systems. The methods include administration of a therapeutic liposome containing an active agent, followed by a administration of an attacking liposome that induces release of the agents from the therapeutic liposome.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: February 26, 2019
    Assignee: MALLINCKRODT LLC
    Inventors: Jun Yang, Stephen H. Wu, Cliff J. Herman
  • Patent number: 10039716
    Abstract: The present invention provides a composition for the treatment of cancer including zwitterionic liposomes consisting essentially of: 50-65 mol % of a phosphatidylcholine lipid, 30-45 mol % of cholesterol, and 2-8 mol % of a PEG-lipid; and cisplatin. Cisplatin is encapsulated in the liposomes in an amount such that the ratio of the total lipid weight to the cisplatin weight is from about 65:1 to about 95:1. Methods for the preparation of liposomal cisplatin and the treatment of cancer are also disclosed.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: August 7, 2018
    Assignee: MALLINCKRODT LLC
    Inventor: William McGhee
  • Patent number: 9914695
    Abstract: Processes for preparing 3-substituted phenylalkylamines comprising reacting a phenyl boronic compound with an ?-? unsaturated carbonyl-containing compound via an asymmetric 1,4-addition reaction, followed by reductive alkylation. The processes may be useful in the synthesis of tapentadol.
    Type: Grant
    Filed: July 6, 2016
    Date of Patent: March 13, 2018
    Assignee: Mallinckrodt LLC
    Inventors: Doug Teramura, Subo Liao
  • Publication number: 20180008596
    Abstract: The present invention generally relates to processes for preparing highly pure morphinan-6-one products. The processes involve reducing the concentration of alpha, beta unsaturated ketone compounds present as impurities in morphinan 6 one products or reaction mixtures including morphinan 6 one compounds by treatment with a sulfur-containing compound.
    Type: Application
    Filed: September 21, 2017
    Publication date: January 11, 2018
    Applicant: Mallinckrodt LLC
    Inventors: Henry J Buehler, William E Dummitt, Anthony Mannino, Dennis C Aubuchon, Hong Gu
  • Patent number: 9856251
    Abstract: The present invention provides processes for the synthesis of substituted berbine compounds. Also provided are intermediates used in the synthesis of substituted berbine compounds.
    Type: Grant
    Filed: August 12, 2016
    Date of Patent: January 2, 2018
    Assignee: Mallinckrodt LLC
    Inventors: Peter X. Wang, Frank W. Moser, Gary L. Cantrell, Christopher W. Grote
  • Patent number: 9766152
    Abstract: A leak testing system (210) for medicament sachets (200) is disclosed. The system (210) includes a base section (220) having a flat surface (226). A plurality of guide rods (230) extend from this flat surface (226) of the base section (220). A press section (240) incorporates a plurality of through-holes (242) that are used to movably mount the press section (240) on the noted guide rods (230). The press section (240) includes a flat surface (246) that is maintained in at least substantially parallel relation to the flat surface (226) of the base section (220). A medicament pouch (200) may be compressed between these flat surfaces (226, 246) of the base section (220) and the press section (240) by sliding the press section (240) along the guide rods (230) and in the direction of the base section (240). Multiple press plates can be added to adjust the force and weight to test for leaks.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: September 19, 2017
    Assignee: MALLINCKRODT LLC
    Inventors: James G. Kostelc, Amelia G. Lukitsch
  • Patent number: 9730885
    Abstract: Pharmaceutical compositions comprising at least one active pharmaceutical ingredient or a pharmaceutically acceptable salt thereof, at least one hydrophilic plastomer, at least one hydrophilic elastomer, and at least one deliquescent plasticizer, wherein the pharmaceutical compositions provide extended release of the API and have abuse deterrent properties. Methods for preparing the pharmaceutical compositions in which the components of the composition are humidified such that the deliquescent plasticizer deliquesces, thereby plasticizing the hydrophilic polymers.
    Type: Grant
    Filed: July 11, 2013
    Date of Patent: August 15, 2017
    Assignee: Mallinckrodt LLC
    Inventors: Brad L. Gower, Carlos H. Castaneda, Jae Han Park, Clifford J. Herman
  • Patent number: 9717686
    Abstract: The present invention provides methods for delivery of therapeutic agents to a subject using multi-component liposomal systems. The methods include administration of a therapeutic liposome containing an active agent, followed by a administration of an attacking liposome that induces release of the agents from the therapeutic liposome.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: August 1, 2017
    Assignee: MALLINCKRODT LLC
    Inventors: Jun Yang, Stephen H. Wu, Cliff J. Herman
  • Patent number: 9713592
    Abstract: The present invention relates to an oral pulse release pharmaceutical composition, which comprises a polymer matrix core, wherein at least one pharmaceutically active ingredient is distributed within the core and on the outer surface of the core. Amphetamine salts, among a number of other pharmaceutically active ingredients, can be formulated as a pharmaceutical composition described herein. The present invention also provides a method for preparing an immediate release component on a solid pharmaceutical formulation.
    Type: Grant
    Filed: March 22, 2006
    Date of Patent: July 25, 2017
    Assignee: MALLINCKRODT LLC
    Inventors: Ashwini Gadre, Mark R. Benmuvhar, Brian Kai-Ming Cheng, Vishal K. Gupta, Cliff J. Herman
  • Patent number: 9662387
    Abstract: The present invention provides optical agents comprising optically functional cross linked supramolecular structures and assemblies useful for tandem optical imaging and therapy. Supramolecular structures and assemblies of the present invention include optically functional shell-cross linked micelles wherein optical functionality is achieved via incorporation of one or more linking groups that include one or more photoactive moieties. The present invention further includes imaging and therapeutic methods using one or more optical agents of the present invention including optically functional shell cross-linked micelles having an associated therapeutic agent.
    Type: Grant
    Filed: February 26, 2016
    Date of Patent: May 30, 2017
    Assignees: Mallinckrodt LLC, Washington University, The Texas A&M University System
    Inventors: William L. Neumann, Richard B. Dorshow, John N. Freskos, Karen L. Wooley, Nam S. Lee, Yun Lin, Guorong Sun
  • Patent number: 9629837
    Abstract: The present disclosure provides extended release pharmaceutical compositions comprising oxycodone and acetaminophen that produce a quick initial onset of analgesia, yet, maintain analgesia for about 12 hours after administration of the composition to a subject in need thereof. The pharmaceutical compositions disclosed herein also reduce the levels of acetaminophen in a subject's blood near the end of the dosing interval because the acetaminophen released by the pharmaceutical composition is being eliminated by a subject's body faster than it is being absorbed.
    Type: Grant
    Filed: March 17, 2015
    Date of Patent: April 25, 2017
    Assignee: MALLINCKRODT LLC
    Inventors: Krishna Devarakonda, Michael J. Giuliani, Vishal K. Gupta, Ralph A. Heasley, Susan Shelby
  • Patent number: 9593111
    Abstract: The present disclosure provides oxidized berbine derivatives, processes for their preparation, and methods of using the oxidized berbine derivatives.
    Type: Grant
    Filed: June 11, 2015
    Date of Patent: March 14, 2017
    Assignee: Mallinckrodt LLC
    Inventor: Christopher W. Grote
  • Patent number: 9579252
    Abstract: A pharmaceutical product supply is disclosed in the form of a container, a pharmaceutical product receiver, pharmaceutical product, an adhesive, and at least one release liner. The pharmaceutical product receiver includes a plurality of receptacles for pharmaceutical product. The container is initially disposed in a first configuration where all of the pharmaceutical product receiver receptacles may be accessible. The container is thereafter disposable in a second configuration where no covering for any of the pharmaceutical product receiver receptacles is accessible through any openable access incorporated by the container. One or more release liners may be moved to expose adhesive for disposing and retaining the container in its second configuration. The noted second configuration of the container facilitates disposal of the pharmaceutical product supply (e.g.
    Type: Grant
    Filed: May 19, 2015
    Date of Patent: February 28, 2017
    Assignee: Mallinckrodt LLC
    Inventors: Robert J. Ziemba, Vernon D. Ortenzi
  • Patent number: 9562014
    Abstract: The present invention provides (+)-morphinans comprising Toll-like receptor 9 (TLR9) antagonist activity, as well as methods for using the (+)-morphinans to treat pain. Also provided are pharmaceutical combination compositions comprising a (+)-morphinan and an opioid agonist/monoamine reuptake inhibitor, as well as methods for using the combination compositions to treat pain.
    Type: Grant
    Filed: December 22, 2010
    Date of Patent: February 7, 2017
    Assignee: Mallinckrodt LLC
    Inventors: Bobby N. Trawick, David W. Berberich, Christopher W. Grote
  • Patent number: 9556108
    Abstract: The invention provides methods for preparing substituted phenylalkanes. In particular, the processes comprise reacting a phenyl boronic compound with an ?-? unsaturated carbonyl-containing compound via an asymmetric 1,4-addition reaction. The processes may be useful in the synthesis of tapentadol.
    Type: Grant
    Filed: July 10, 2015
    Date of Patent: January 31, 2017
    Assignee: Mallinckrodt LLC
    Inventors: Subo Liao, Joseph McClurg, Bobby Trawick
  • Patent number: 9539328
    Abstract: The present disclosure provides an extended release pharmaceutical composition comprising hydrocodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: January 10, 2017
    Assignee: MALLINCKRODT LLC
    Inventors: Krishna Devarakonda, Michael J. Giuliani, Vishal K. Gupta, Ralph A. Heasley, Susan Shelby