Patents Assigned to Mallinckrodt Pharma IP Trading D.A.C.
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Patent number: 10562956Abstract: The present invention relates to nucleotide sequences encoding a fibrinogen alpha, beta or gamma chain. The sequences are optimized for expression in a eukaryotic cell culture system. Such optimized nucleotide sequences allow for the efficient expression of recombinant fibrinogen and variants thereof in intact form in a eukaryotic cell culture system.Type: GrantFiled: October 24, 2016Date of Patent: February 18, 2020Assignee: Mallinckrodt Pharma IP Trading D.A.C.Inventors: Abraham Bout, Joseph Grimbergen, Jacob Koopman
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Patent number: 10456505Abstract: The present invention relates to extravascular supports. In particular, to extravascular supports which are used in vein grafting. More in particular, it relates to extravascular supports which are biodegradable.Type: GrantFiled: January 6, 2017Date of Patent: October 29, 2019Assignee: Mallinckrodt Pharma IP Trading D.A.C.Inventor: Jacob Laurens Koopman
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Patent number: 10052426Abstract: The present invention provides methods of administering nitric oxide (NO) to a patient, the method comprising delivering nitric oxide-containing gas directly into arterial or arterialized blood. The methods of the present invention may be used in the treatment or prevention of a variety of diseases and disorders responsive to nitric oxide, including those resulting from ischemia or hypoxia.Type: GrantFiled: May 30, 2013Date of Patent: August 21, 2018Assignee: Mallinckrodt Pharma IP Trading D.A.C.Inventors: Brahm Goldstein, Jim Potenziano
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Patent number: 10010705Abstract: Provided is a device for the dispensing of powders of the type in which a generated gas flow entrains the powder to be dispensed and carries the powder from the device via a barrel. The barrel has a bore including a main portion with a continuous internal surface, and is characterized in that the length of the main portion is at least fifteen times its maximum internal diameter; and/or the internal bore of the main portion is tapered; and/or the barrel has an outwardly flared outlet portion.Type: GrantFiled: December 23, 2011Date of Patent: July 3, 2018Assignee: Mallinckrodt Pharma IP Trading D.A.C.Inventors: Paul Greenhalgh, Eliane Schutte
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Patent number: 10004787Abstract: The present invention relates to fibrinogen preparations enriched in ?-extended fibrinogen. Compositions comprising such preparations show improved clotting properties compared to preparations based on HMW Fib which typically contain no or only low amounts of ?-extended fibrinogen. In particular, clot formation time and the clot strength of a clot made by ?-extended fibrinogen are improved. In addition, plasmin-mediated degradation of ?-extended fibrinogen is reduced as compared to plasma derived fibrinogen.Type: GrantFiled: June 5, 2017Date of Patent: June 26, 2018Assignee: Mallinckrodt Pharma IP Trading D.A.C.Inventors: Joseph Grimbergen, Jacob Koopman, Abraham Bout
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Patent number: 9827205Abstract: The invention provides a composition comprising a mixture of first microparticles that comprise fibrinogen and trehalose, and second microparticles that comprise thrombin and trehalose. The invention further provides methods for treating wounds by administering the novel microparticle composition.Type: GrantFiled: December 12, 2009Date of Patent: November 28, 2017Assignees: Mallinckrodt Pharma IP Trading D.A.C., Quadrant Drug Delivery LimitedInventors: Nicola Whitfield, Jaap Koopman, Jos Grimbergen
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Patent number: 9789221Abstract: Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. Phase invertible compositions in accordance with the invention are prepared by combining a liquid proteinaceous substrate and a liquid crosslinking composition, where the liquid crosslinking composition includes a macromolecular crosslinking agent. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.Type: GrantFiled: February 11, 2014Date of Patent: October 17, 2017Assignee: Mallinckrodt Pharma IP Trading D.A.C.Inventors: Ronald Dieck, Ian J. Handley, Neil Winterbottom, Joanna Wong
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Patent number: 9717821Abstract: The present invention relates to novel formulations comprising a dry powder fibrin sealant comprised of a mixture of fibrinogen and/or thrombin, for use in the treatment of wounds or injuries, in particular for use as a topical hemostatic composition or for surgical intervention.Type: GrantFiled: July 6, 2012Date of Patent: August 1, 2017Assignee: Mallinckrodt Pharma IP Trading D.A.C.Inventors: Eliane Schutte, Linda Zuckerman, Richard Senderoff, Glen Martyn
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Patent number: 9629798Abstract: Provided herein are hemostatic compositions. In one embodiment, the hemostatic composition includes cross-linked polymer microspheres, such as cross-linked gelatin microspheres with pores. In another embodiment, the hemostatic composition comprises an additive such as a wetting agent, a suspending agent, or both. The hemostatic compositions may also include a hemostatic agent such as thrombin, and may include a high concentration of thrombin. The hemostatic compositions may also include plasma. Also provided herein are devices for dispersing said hemostatic compositions in a diluent, and delivering said dispersed hemostatic composition. The hemostatic compositions may also fabricated with a selected geometry as administration suggests.Type: GrantFiled: March 26, 2009Date of Patent: April 25, 2017Assignee: MALLINCKRODT PHARMA IP TRADING D.A.C.Inventors: Richard I. Senderoff, Jeffrey D. Meyer, Emily N. Rollins, Steven D. Hughes, Richard M. Garcia, Paul D. Bishop, Gerald W. Lasser
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Patent number: 9597062Abstract: Provided is a surgical applicator and applicator tip configured to attach in fluid communication, for the delivery of beneficial fluids. The applicator tip may also be configured to reversibly attach, in fluid communication, with a pledget. For example, the applicator tip may include male or female threads, and the pledget has threads that are complementary to the thread configuration of the tip. The applicator tip may further comprise at least one fluid transfer lumen for transfer of a fluid from the tip to the pledget. In one embodiment of the invention, the tip includes male threads and the pledget includes a pledget attachment portion. There are also provided methods for connecting the tip to the pledget. In one embodiment, a tip comprising male threads is attached to the pledget, comprising a pledget attachment portion, by tapping or pressing the tip into the pledget attachment portion.Type: GrantFiled: April 27, 2009Date of Patent: March 21, 2017Assignee: Mallinckrodt Pharma IP Trading D.A.C.Inventors: William Allan Alexander, Paul D. Bishop, Steve R. Carter, Alisa M. Littau
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Patent number: 9440000Abstract: Biocompatible phase invertible proteinaceous compositions and methods for making and using the same are provided. The subject phase invertible compositions are prepared by combining a crosslinker and a proteinaceous substrate. The proteinaceous substrate includes one or more proteins and a polyamine, where the polyamine and a proteinaceous substrate are present in synergistic viscosity enhancing amounts, and may also include one or more of: a carbohydrate, a tackifying agent, a plasticizer, or other modification agent. In certain embodiments, the crosslinker is a heat-treated dialdehyde, e.g., heat-treated glutaraldehyde. Also provided are kits for use in preparing the subject compositions. The subject compositions, kits and systems find use in a variety of different applications.Type: GrantFiled: February 11, 2014Date of Patent: September 13, 2016Assignee: Mallinckrodt Pharma IP Trading D.A.C.Inventors: Ian J. Handley, Joanna Wong