Abstract: A peptide comprising the amino acid sequence: U-O-X-glu-Z or O-X-glu-Z-ala-glu, wherein: U is an amino acid residue selected from val and ile; O is an amino acid residue selected from ala and thr: X is an amino acid residue selected from asp and glu: and Z is an amino acid residue selected from ile and val: the use of the peptide in the preparation of a vaccine; a composition for vaccination against malaria induced by Plasmodium falciparum, comprising such peptide in admixture with a pharmaceutically acceptable carrier; and a method of inducing immunity against malaria induced by Plasmodium falciparum, which comprises administering to a person in need of such immunity an effective amount of said composition.
Type:
Grant
Filed:
April 8, 1993
Date of Patent:
March 11, 1997
Assignee:
Malvac Foundation
Inventors:
Niklas Ahlborg, Klavs Berzins, Peter Perlmann