Abstract: A bone biopsy needle assembly is disclosed for withdrawing samples of bone, bone marrow and bone marrow cavity fluids as may be required in biopsy and transplant procedures. The assembly comprises a cannula having a sharpened distal end and a stylet, also having a sharpened distal end, coaxially received in the cannula lumen. The handles of the cannula and the stylet are provided with particular features for mating reception when assembled together to assure their secure alignment during the various operations required in use.