Patents Assigned to Mandom Corporation
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Publication number: 20230057230Abstract: The present invention provides a novel method for detecting an indicator of T cell lymphoma. The method for detecting an indicator of T cell lymphoma includes the step of detecting acetylated tubulin in a T cell that has been collected from a subject.Type: ApplicationFiled: January 7, 2021Publication date: February 23, 2023Applicants: MANDOM CORPORATION, OSAKA UNIVERSITY, PUBLIC UNIVERSITY CORPORATION NAGOYA CITY UNIVERSITYInventors: Manami Toriyama, Fumitaka Fujita, Fumihiro Okada, Akimichi Morita, Motoki Nakamura
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Patent number: 11464720Abstract: This TRPA1 activity inhibitor contains a compound represented by formula (I) wherein R1, R2, R3 and R4 each independently represent a hydrogen atom or a methyl group, and R5, R6, R7 and R8 each independently represent a hydrogen atom, a methyl group or —O—R9—OH (in the formula, R9 represents an alkylene group optionally having a substituent group), provided that at least one group of R5, R6, R7 and R8 is —O—R9—OH.Type: GrantFiled: March 13, 2018Date of Patent: October 11, 2022Assignees: MANDOM CORPORATION, TAKASAGO INTERNATIONAL CORPORATIONInventors: Masayuki Takaishi, Fumitaka Fujita, Hironori Shimizu, Shu Sakuyama, Kenya Ishida, Kenji Maruyama
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Publication number: 20210361549Abstract: Provided is an antiperspirant which serves to control secretion of sweat secreted from sweat glands and is capable of doing so by acting on sweat glands without closing sweat pores, the antiperspirant containing, as an active ingredient to control secretion of sweat secreted from sweat glands, at least one type of pentacyclic compound selected from the group consisting of compounds represented by formula (I): and derivatives thereof, and compounds represented by formula (VII): and derivatives thereof.Type: ApplicationFiled: March 18, 2019Publication date: November 25, 2021Applicants: MANDOM CORPORATION, OSAKA UNIVERSITYInventors: Kie Nakashima, Ryuichiro Kurata, Fumitaka Fujita, Fumihiro Okada
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Patent number: 11085916Abstract: A method for observing the dynamics of sweat glands and a method for evaluating a substance of interest, which are useful for development of a preparation for external application, such as a cosmetic. In each of the methods, an observation sample is used, which is prepared by staining all sweat glands, which are isolated alive, with a staining reagent, and then holding the all sweat glands on a support using at least one material selected from the group consisting of collagen, agarose, basement membrane matrix, poly-D-lysine and a membrane.Type: GrantFiled: July 18, 2017Date of Patent: August 10, 2021Assignees: MANDOM CORPORATION, OSAKA UNIVERSITYInventors: Kie Nakashima, Ryuichiro Kurata, Fumitaka Fujita, Kiyotoshi Sekiguchi, Atsushi Tanemura, Hiroyuki Murota, Ichiro Katayama
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Patent number: 11060061Abstract: An immortalized sweat gland myoepithelial cell which expresses ?-SMA and pan-cytokeratin and has a sphere forming ability after subculture at least 5 times. A method for producing immortalized sweat gland myoepithelial said method comprising: while culturing a cell structure, wherein sweat gland myoepithelial cells are exposed on a surface, in a state of being suspended in a medium, transferring an immortalizing gene into the cells; and then culturing the transgenic structure thus obtained in a state of being suspended in the medium to thereby obtain immortalized sweat gland myoepithelial cells.Type: GrantFiled: August 7, 2018Date of Patent: July 13, 2021Assignees: MANDOM CORPORATION, OSAKA UNIVERSITYInventors: Tomohisa Hayakawa, Ryuichiro Kurata, Fumitaka Fujita, Fumihiro Okada, Kiyotoshi Sekiguchi
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Patent number: 11047849Abstract: Provided is a method for observing a sebaceous gland, the method making it possible to observe dynamics of a sebaceous gland which dynamics are close to dynamics of a sebaceous gland in a living body. The method includes: an anchoring step of anchoring a sebaceous gland structure to a support so that a sebaceous gland that is included in the sebaceous gland structure and is to be observed and the support are not in biological contact with each other, the sebaceous gland structure being obtained by removing all or part of each of dermis and hypodermis from a skin tissue; and an observation step of observing the sebaceous gland structure obtained in the anchoring step.Type: GrantFiled: September 5, 2019Date of Patent: June 29, 2021Assignee: MANDOM CORPORATIONInventors: Shuta Ishizuka, Ryuichiro Kurata
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Publication number: 20210003546Abstract: Provided is a method whereby an objective indicator of an immune-related disease can be rapidly and easily detected, the method comprising detecting, as an indicator of an immune-related disease, a difference in the result of observing a primary cilium of an immune-related cell between a subject specimen and a normal specimen.Type: ApplicationFiled: March 8, 2019Publication date: January 7, 2021Applicants: MANDOM CORPORATION, OSAKA UNIVERSITY, NATIONAL INSTITUTES OF BIOMEDICAL INNOVATION, HEALTH AND NUTRITIONInventors: Manami Toriyama, Fumitaka Fujita, Fumihiro Okada, Ken Ishii
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Publication number: 20200385680Abstract: An immortalized sweat gland myoepithelial cell which expresses ?-SMA and pan-cytokeratin and has a sphere forming ability after subculture at least 5 times. A method for producing immortalized sweat gland myoepithelial said method comprising: while culturing a cell structure, wherein sweat gland myoepithelial cells are exposed on a surface, in a state of being suspended in a medium, transferring an immortalizing gene into the cells; and then culturing the transgenic structure thus obtained in a state of being suspended in the medium to thereby obtain immortalized sweat gland myoepithelial cells.Type: ApplicationFiled: August 7, 2018Publication date: December 10, 2020Applicants: MANDOM CORPORATION, OSAKA UNIVERSITYInventors: Tomohisa Hayakawa, Ryuichiro Kurata, Fumitaka Fujita, Fumihiro Okada, Kiyotoshi Sekiguchi
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Publication number: 20200371090Abstract: Provided is a method for observing a sebaceous gland, the method making it possible to observe dynamics of a sebaceous gland which dynamics are close to dynamics of a sebaceous gland in a living body. The method includes: an anchoring step of anchoring a sebaceous gland structure to a support so that a sebaceous gland that is included in the sebaceous gland structure and is to be observed and the support are not in biological contact with each other, the sebaceous gland structure being obtained by removing all or part of each of dermis and hypodermis from a skin tissue; and an observation step of observing the sebaceous gland structure obtained in the anchoring step.Type: ApplicationFiled: September 5, 2019Publication date: November 26, 2020Applicant: MANDOM CORPORATIONInventors: Shuta Ishizuka, Ryuichiro Kurata
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Publication number: 20200022889Abstract: This TRPA1 activity inhibitor contains a compound represented by formula (I) wherein R1, R2, R3 and R4 each independently represent a hydrogen atom or a methyl group, and R5, R6, R7 and R8 each independently represent a hydrogen atom, a methyl group or —O—R9—OH (in the formula, R9 represents an alkylene group optionally having a substituent group), provided that at least one group of R5, R6, R7 and R8 is —O—R9—OH.Type: ApplicationFiled: March 13, 2018Publication date: January 23, 2020Applicants: MANDOM CORPORATION, TAKASAGO INTERNATIONAL CORPORATIONInventors: Masayuki Takaishi, Fumitaka Fujita, Hironori Shimizu, Shu Sakuyama, Kenya Ishida, Kenji Maruyama
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Publication number: 20200003756Abstract: A method for observing a sebaceous gland, the method being useful for such applications as developing a cosmetic material or other external preparation, and including (I) a step for culturing, in a suspended state in a medium, a sebaceous gland structure in which the dermis and all or a portion of the subcutaneous tissue is removed from a skin tissue, and (II) a step for observing the cultured sebaceous gland structure obtained in step (I).Type: ApplicationFiled: February 28, 2018Publication date: January 2, 2020Applicant: MANDOM CORPORATIONInventors: Shuta Ishizuka, Ryuichiro Kurata
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Publication number: 20190049429Abstract: A method for observing the dynamics of sweat glands and a method for evaluating a substance of interest, which are useful for development of a preparation for external application, such as a cosmetic. In each of the methods, an observation sample is used, which is prepared by staining all sweat glands, which are isolated alive, with a staining reagent, and then holding the all sweat glands on a support using at least one material selected from the group consisting of collagen, agarose, basement membrane matrix, poly-D-lysine and a membrane.Type: ApplicationFiled: July 18, 2017Publication date: February 14, 2019Applicants: MANDOM CORPORATION, OSAKA UNIVERSITYInventors: Kie Nakashima, Ryuichiro Kurata, Fumitaka Fujita, Kiyotoshi Sekiguchi, Atsushi Tanemura, Hiroyuki Murota, Ichiro Katayama
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Patent number: 9737467Abstract: The present invention provides a body odor suppressing agent that contains activated carbon and that has excellent body odor suppressing effects, causes no black soiling on an object to be coated, and has excellent practical aptitude. The present invention also provides a body odor suppressing agent having an excellent feeling of use when the agent is applied to the skin. The present invention further provides a body odor suppressing agent capable of preventing nozzles from clogging when the agent is packed into a spray container and used. The body odor suppressing agent of the present invention includes a titanium oxide-coated activated carbon including an activated carbon having an average particle diameter of 15 to 50 ?m and a titanium oxide present over the surface of the activated carbon.Type: GrantFiled: November 8, 2016Date of Patent: August 22, 2017Assignee: MANDOM CORPORATIONInventors: Takeshi Hara, Hironori Shimizu
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Patent number: 8992894Abstract: An oral stain remover which can remove a stain or a dental plaque effectively without a need of brushing the surface of teeth with a toothbrush or the like, and an oral composition containing the stain remover. An oral stain remover contains a salt of ultraphosphoric acid, and an oral composition contains the oral stain remover.Type: GrantFiled: June 14, 2007Date of Patent: March 31, 2015Assignees: Mandom Corporation, REGENETISS Inc.Inventors: Toshikazu Shiba, Atsushi Saitou, Kazuyoshi Okada, Yoshio Tsujino
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Publication number: 20150013712Abstract: The present invention provides a powdery solid hair cosmetic that enables easy hairdressing, enables hairdressing into an intended hairstyle without sticky feeling, can impart a natural texture, and has an unprecedented, novel form. The powdery solid composition for hair of the present invention is in a powdery solid form, is used for hair, and contains a powder and an oil.Type: ApplicationFiled: March 27, 2013Publication date: January 15, 2015Applicant: MANDOM CORPORATIONInventors: Takeharu Ishii, Takuji Asada
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Patent number: 7939307Abstract: Modified CueO having excellent enzymatic activity and a composition for dyeing keratin fiber which contains the enzyme. A recombinant protein having an enzymatic activity for oxidizing p-phenylenediamine, the protein is obtained by removing from CueO at least one member selected from the group consisting of helix 5, helix 6, and helix 7; and the composition for dyeing keratin fiber containing the recombinant protein and an oxidation dye.Type: GrantFiled: April 14, 2006Date of Patent: May 10, 2011Assignees: National University Corporation Kanazawa University, Mandom CorporationInventors: Kaori Otsuka, Yoshio Tsujino, Yusuke Konno, Shinji Kurose, Kunishige Kataoka, Takeshi Sakurai
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Publication number: 20100205754Abstract: Modified CueO having excellent enzymatic activity and a composition for dyeing keratin fiber which contains the enzyme. A recombinant protein having an enzymatic activity for oxidizing p-phenylenediamine, the protein is obtained by removing from CueO at least one member selected from the group consisting of helix 5, helix 6, and helix 7; and the composition for dyeing keratin fiber containing the recombinant protein and an oxidation dye.Type: ApplicationFiled: April 14, 2006Publication date: August 19, 2010Applicants: NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSIT, MANDOM CORPORATIONInventors: Kaori Otsuka, Yoshio Tsujino, Yusuke Konno, Shinji Kurose, Kunishige Kataoka, Takeshi Sakurai
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Patent number: 7754774Abstract: The purpose of the present invention is to provide antiseptic disinfectant, and cosmetics and toiletries, medicine or food containing the same, which enhance the antibacterial activity that 1,2-alkanediol originally have against a broad range of strains by compounding 1,2-alkanediol with 5-10 carbons and a certain fragrance component. The present invention relates to an antiseptic disinfectant, and cosmetics and toiletries, medicine or food containing the same, which include 1,2-alkanediol with 5-10 carbons, and one or more materials selected from a group of thymol, eugenol, citronellal, terpinyl acetate, citronellol and ?-pinene.Type: GrantFiled: September 25, 2003Date of Patent: July 13, 2010Assignee: Mandom CorporationInventors: Aki Kobayashi, Hiroya Okamoto, Fumihiro Okada
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Patent number: 7632871Abstract: The present invention relates to methods for producing and using antiseptic disinfectant, cosmetic and toiletries, medicine or food and method for antiseptically disinfecting a cosmetic and toiletries, medicine or food. The cosmetic and toiletries, medicine or food contain an antiseptic disinfectant comprising 1,2-alkanediol with 5-10 carbons and a fragrance component, and the fragrance component enhances the antibacterial activity that the 1,2-alkanediol originally has against a broad range of strains.Type: GrantFiled: May 19, 2006Date of Patent: December 15, 2009Assignee: Mandom CorporationInventors: Aki Kobayashi, Hiroya Okamoto, Fumihiro Okada
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Publication number: 20090280072Abstract: An oral stain remover which can remove a stain or a dental plaque effectively without a need of brushing the surface of teeth with a toothbrush or the like, and an oral composition containing the stain remover. An oral stain remover contains a salt of ultraphosphoric acid, and an oral composition contains the oral stain remover.Type: ApplicationFiled: June 14, 2007Publication date: November 12, 2009Applicant: MANDOM CORPORATIONInventors: Toshikazu Shiba, Atsushi Saitou, Kazuyoshi Okada, Yoshio Tsujino