Patents Assigned to MannKind Corporation
  • Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
    Patent number: 9283193
    Abstract: Methods are provided for coating crystalline microparticles with an active agent by altering the surface properties of the microparticles in order to facilitate favorable association on the microparticle by the active agent. Type of surface properties that are altered by the disclosed methods include by electrostatic properties, hydrophobic properties and hydrogen bonding properties.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: March 15, 2016
    Assignee: MannKind Corporation
    Inventors: Keith A. Oberg, Joseph Sulner, Marshall L. Grant
  • Diketopiperazine salts for drug delivery and related methods
    Patent number: 9259471
    Abstract: Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent. Related methods for making and using the biologically active agent delivery compositions are also provided. In certain embodiments, the pharmaceutically acceptable salts described can be formed by removal of solvent by methods including distillation, evaporation, spray drying or lyophilization.
    Type: Grant
    Filed: January 8, 2014
    Date of Patent: February 16, 2016
    Assignee: MannKind Corporation
    Inventors: Andrea Leone-Bay, Destardi Moye-Sherman, Bryan R. Wilson
  • Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
    Patent number: 9241903
    Abstract: Methods are provided for drying a particle. Specifically, there is provided a spray-dried diketopiperazine-insulin particle formulation having improved aerodynamic performance and in which the active agent is more stabile and efficiently delivered as compared to that of the lyophilized diketopiperazine-insulin formulation. The dry powders have utility as pharmaceutical formulations for pulmonary delivery.
    Type: Grant
    Filed: July 15, 2013
    Date of Patent: January 26, 2016
    Assignee: MannKind Corporation
    Inventors: Bryan R. Wilson, Marshall Grant
  • IRE-1? inhibitors
    Patent number: 9241942
    Abstract: Compounds which directly inhibit IRE-1? activity in vitro, prodrugs, and pharmaceutically acceptable salts thereof. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response and can be used as single agents or in combination therapies.
    Type: Grant
    Filed: November 13, 2013
    Date of Patent: January 26, 2016
    Assignee: MannKind Corporation
    Inventors: John Bruce Patterson, David Gregory Lonergan, Gary A. Flynn, Qingping Zeng, Peter V. Pallai
  • Methods and compositions for treating pain
    Patent number: 9233159
    Abstract: Methods and compositions for treating pain are disclosed. The compositions are based on dry powders comprising microparticles of diketopiperazines and an analgesic active agent. The analgesic in the compositions comprises one or more peptide analgesics or derivatives thereof, which are administered to a subject using a pulmonary inhalation drug delivery system comprising a dry powder inhaler and the analgesic composition. The present compositions produce fewer side effects associated with current opioid therapy.
    Type: Grant
    Filed: October 24, 2012
    Date of Patent: January 12, 2016
    Assignees: MannKind Corporation, Torrey Pines Institute for Molecular Studies
    Inventors: Andrea Leone-Bay, Richard A. Houghten, Joseph J. Guarneri, Grayson W. Stowell
  • Substituted diketopiperazine analogs for use as drug delivery agents
    Patent number: 9220687
    Abstract: Disclosed are drug delivery systems for the delivery of small molecule and macromolecular drugs. More particularly, disclosed are substituted analogs of 3,6-di(alkyl-4 aminobutyl)-2,5-diketopiperazine (which may also be referred to DKP), their use in the formulation of both small molecule and macromolecular drugs including therapeutic, prophylactic and diagnostic agents, stabilizing agents and systems for their delivery.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: December 29, 2015
    Assignee: MannKind Corporation
    Inventor: Kelly Sullivan Kraft
  • Powder dispenser modules and powder dispenser assemblies
    Patent number: 9221561
    Abstract: A powder dispenser module (54) includes a housing (150) that defines a conduit connecting a powder inlet and a powder outlet, a feed wand (160) to move powder through the conduit from the powder inlet to the powder outlet, the feed wand (200) including a lower feed element (230) coupled to a first drive shaft and an upper feed element (220) coupled to a second drive shaft, a first actuator coupled to the first drive shaft to rotate the lower feed element (230), and a second actuator coupled to the second drive shaft to rotate the upper feed element (220). In other embodiments, the feed wand (200) includes a shaft having a fluidizing element and an actuator produces oscillatory movement of the feed wand during dispensing of powder. Dispenser module arrays include one or a few rows of dispenser modules.
    Type: Grant
    Filed: August 5, 2009
    Date of Patent: December 29, 2015
    Assignee: MannKind Corporation
    Inventors: Rajesh Maheshwari, Rolf Scharger, Trent A. Poole, Per B. Fog
  • DETERMINING PERCENT SOLIDS IN SUSPENSION USING RAMAN SPECTROSCOPY
    Publication number: 20150369743
    Abstract: Methods and apparatus are provided for determining weight percent of solids in a suspension using Raman spectroscopy. The methods can be utilized to acquire Raman spectral data from the suspension and to determine weight percent of solids in a process being carried out, for example, in a vessel, without the need to remove samples for analysis. The weight percent of the solids can be determined with a desired accuracy in a relatively short time, typically 10 minutes or less. The acquired Raman spectral data may be processed by chemometric software using, for example, a partial least squares algorithm and data pretreatment to provide a predicted value of weight percent solids. In some embodiments, the invention is used to determine the weight percent of microparticles of a diketopiperazine in an aqueous solution.
    Type: Application
    Filed: August 31, 2015
    Publication date: December 24, 2015
    Applicant: MannKind Corporation
    Inventors: Jason J. Antunovich, Arthur T. Hamfeldt, Rodney J. Woods, Sam C. Shum
  • Methods for the synthesis of activated ethylfumarates and their use as intermediates
    Patent number: 9193691
    Abstract: Disclosed embodiments relate to improved methods for the synthesis of activated fumarate intermediates and their use in chemical synthesis. Disclosed embodiments describe the synthesis of activated fumarate esters including those derived from activating groups including: 4-nitrophenyl, diphenylphosphoryl azide, pivaloyl chloride, chlorosulfonyl isocyanate, p-nitrophenol, MEF, trifluoroacetyl and chlorine, for example, ethyl fumaroyl chloride and the subsequent use of the activated ester in situ. Further embodiments describe the improved synthesis of substituted aminoalkyl-diketopiperazines from unisolated and unpurified intermediates allowing for improved yields and reactor throughput.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: November 24, 2015
    Assignee: MannKind Corporation
    Inventors: Kelly Sullivan Kraft, John J. Freeman, Paul Serwinski, Vinnie Pavia, Otto Phanstiel, Navneet Kaur
  • Formation of N-protected 3,6-bis-(4-aminobutyl) -2, 5-diketopiperazine through a cyclic ?--protected active amino ester intermediate
    Patent number: 9187433
    Abstract: A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided. The method includes obtaining a cyclic ?-N protected active amino ester and adding it to a mixture of an amine catalyst in an organic solvent.
    Type: Grant
    Filed: February 23, 2015
    Date of Patent: November 17, 2015
    Assignee: MANNKIND CORPORATION
    Inventors: John J. Freeman, Otto Phanstiel, William Elliot Bay, Kelly Sullivan Kraft
  • Determining percent solids in suspension using raman spectroscopy
    Patent number: 9140651
    Abstract: Methods and apparatus are provided for determining weight percent of solids in a suspension using Raman spectroscopy. The methods can be utilized to acquire Raman spectral data from the suspension and to determine weight percent of solids in a process being carried out, for example, in a vessel, without the need to remove samples for analysis. The weight percent of the solids can be determined with a desired accuracy in a relatively short time, typically 10 minutes or less. The acquired Raman spectral data may be processed by chemometric software using, for example, a Partial Least Squares algorithm and data pretreatment to provide a predicted value of weight percent solids. In some embodiments, the invention is used to determine the weight percent of microparticles of a diketopiperazine in an aqueous solution.
    Type: Grant
    Filed: May 4, 2011
    Date of Patent: September 22, 2015
    Assignee: MannKind Corporation
    Inventors: Jason J. Antunovich, Arthur T. Hamfeldt, Rodney J. Woods, Sam C. Shum
  • Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
    Patent number: 9089497
    Abstract: Methods are provided for promoting the adsorption of an active agent to microparticles by modifying the structural properties of the active agent in order to facilitate favorable association to the microparticle.
    Type: Grant
    Filed: September 16, 2010
    Date of Patent: July 28, 2015
    Assignee: MannKind Corporation
    Inventors: Mark Hokenson, Keith A. Oberg
  • Method for treating hyperglycemia with GLP-1
    Patent number: 9078866
    Abstract: A method for treating hyperglycemia and/or diabetes in a subject is provided. In particular, the method is directed for the treatment of patients with Type 2 diabetes mellitus who have a fasting blood glucose concentration greater than about 8 mM, wherein the patient is administered a formulation comprising a GLP-1 molecule and a diketopiperazine by pulmonary inhalation with a dry powder inhalation system.
    Type: Grant
    Filed: January 8, 2010
    Date of Patent: July 14, 2015
    Assignee: MannKind Corporation
    Inventors: Donald Costello, Peter Richardson, Robert A. Baughman, Mark T. Marino
  • Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
    Patent number: 9066881
    Abstract: Methods are provided for promoting the adsorption of an active agent to microparticles by modifying the structural properties of the active agent in order to facilitate favorable association to the microparticle.
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: June 30, 2015
    Assignee: MannKind Corporation
    Inventors: Mark Hokenson, Keith A. Oberg
  • Unit dose capsules and dry powder inhaler
    Patent number: 9061111
    Abstract: Described is a dry powder inhaler comprising an intake section; a mixing section, and a mouthpiece.
    Type: Grant
    Filed: February 29, 2012
    Date of Patent: June 23, 2015
    Assignee: MannKind Corporation
    Inventors: Solomon S. Steiner, Robert Feldstein, Per B. Fog, Trent A. Poole
  • IRE-1? inhibitors
    Patent number: 9040714
    Abstract: Compounds which directly inhibit IRE-1? activity in vitro, prodrugs, and pharmaceutically acceptable salts there-of. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agents or in combination therapies.
    Type: Grant
    Filed: April 5, 2011
    Date of Patent: May 26, 2015
    Assignee: MannKind Corporation
    Inventors: Qingping Zeng, Andras Toro, John Bruce Patterson, Warren Stanfield Wade, Zoltan Zubovics, Yun Yang, Zhipeng Wu
  • Laser diffraction with inhaler enclosed in positive pressure chamber
    Patent number: 9041925
    Abstract: The present disclosure relates to an improved device and methods for adapting to a laser diffraction apparatus used for measuring particle size distribution and density of the plume of a powder composition emitted from a dry powder inhaler.
    Type: Grant
    Filed: July 10, 2013
    Date of Patent: May 26, 2015
    Assignee: MannKind Corporation
    Inventors: Benoit Adamo, Saiyam Shah, Chad C. Smutney
  • Apparatus and method for simulating inhalation efforts
    Patent number: 9016147
    Abstract: An inhalation simulation system is provided for use with inhalers in particular breath-powered dry powder inhalers. The simulation system can recreate a patient's inhalation profile obtained with an inhaler adapted with a sensing and monitoring device for the detection of characteristic signals generated from the inhaler in use, which signals are transmitted to a computer with an algorithm which is configured to analyze the signals and generate new signals via a transmitter to actuate the inhalation simulation system component parts so that a subject's inhalation profile is replicated simultaneously or in real-time, or stored for later use. Methods of measuring the performance of inhalers are also provided.
    Type: Grant
    Filed: November 3, 2010
    Date of Patent: April 28, 2015
    Assignee: MannKind Corporation
    Inventors: Benoit Adamo, John M. Polidoro, Dennis Overfield, Carl R. Sahi, Brendan Laurenzi, Chad C. Smutney, Spencer P. Kinsey
  • Potentiation of glucose elimination
    Patent number: 9006175
    Abstract: Methods related to the treatment of diabetes and improving the efficiency of insulin utilization are provided. The method enables effective control of prandial glucose levels while reducing the risk of postprandial hypoglycemia. In particular, methods of potentiating the activity of endogenous insulin in type 2 diabetics and exogenous long-acting insulin in diabetics requiring basal insulin replacement are provided.
    Type: Grant
    Filed: January 10, 2006
    Date of Patent: April 14, 2015
    Assignee: MannKind Corporation
    Inventors: Anders Hasager Boss, Solomon S. Steiner, Rodney J. Woods, Joseph W. Sulner
  • Formation of N-protected bis-3,6-(4-aminobutyl)-2,5-diketopiperazine through a cyclic alpha-N-protected amino ester
    Patent number: 8962836
    Abstract: A method for the synthesis of N-protected 3,6-aminoalkyl-2,5-diketopiperazines is provided. The method includes obtaining a cyclic ?-N protected active amino ester and adding it to a mixture of an amine catalyst in an organic solvent.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: February 24, 2015
    Assignee: MannKind Corporation
    Inventors: John J. Freeman, Otto Phanstiel, William Elliot Bay, Kelly Sullivan Kraft