Patents Assigned to Manufacturas Humberto to Buele Hijos, S.
  • Publication number: 20040267027
    Abstract: A synthesis procedure for the manufacture of byphenylimidazolyl-(1)-phenylmethane involves the reduction of 4-phenyl-benzophenone and subsequent reaction of biphenyl-phenyl-carbinol with imidazole. In a preferred form, there are two synthesis steps, the first step being the reduction of 4-phenyl-benzophenone to biphenyl-phenyl-carbinol being with sodium borohydride in the presence of alumina, and the second step being the reaction between biphenyl-phenyl-carbinol and imidazole assisted by microwaves, in the absence of any organic or inorganic solvents, obtaining a yield between 70 to 74% of pure product in a total reaction time of no more than three hours.
    Type: Application
    Filed: March 22, 2004
    Publication date: December 30, 2004
    Applicant: MANUFACTURAS HUMBERTO TO BUELE HIJOS, S.
    Inventors: Erlinda Handal Vega, Carmen Elena Arias, Jorge Manuel Collazo Garcia
  • Patent number: RE41254
    Abstract: Synthesis of Bifonazole by reducing 4-phenylbenzophenone to the alcohol and reacting the alcohol in solid phase under microwave irradiation with imidazole.
    Type: Grant
    Filed: May 17, 2001
    Date of Patent: April 20, 2010
    Assignee: Manufacturas Humberto to Buele Hijos, S.
    Inventors: Erlinda Handal Vega, Carmen Elena Arias, Jorge Manuel Collazo Garcia