Abstract: The present invention relates to a method for screening maternal urine samples for changes in the pattern of mass spectral fingerprinting which have been found to be characteristic of fetal aneuploidies such as Down's Syndrome and have application for the 5 screening of other fetal abnormalities and disorders of pregnancy including gestational trophoblastic diseases.
Type:
Grant
Filed:
March 20, 2014
Date of Patent:
August 27, 2019
Assignee:
Map IP Holding Limited
Inventors:
Raymond Kruse Iles, Stephen Andrew Butler
Abstract: The method describes rapid screening of whole blood samples, pin prick and blood spot cards, subjected to MALDI-ToF Mass spectrometry. The spectra is generated and compared to those from normal healthy controls. Characteristic spectra are indicative of the presence of a hemoglobinopathy and the method can be used to screen/diagnose all sickle cell diseases, alpha and beta Thalassemias.
Type:
Grant
Filed:
August 27, 2015
Date of Patent:
July 23, 2019
Assignee:
Map IP Holding Limited
Inventors:
Raymond Kruse Iles, Jason Kruse Iles, Thomas Abban, Suzanne Margaret Elizabeth Docherty, Mahmoud Naase
Abstract: The method describes rapid screening of whole blood samples, pin prick and blood spot cards, subjected to MALDI-ToF Mass spectrometry. The spectra is generated and compared to those from normal healthy controls. Characteristic spectra are indicative of the presence of a hemoglobinopathy and the method can be used to screen/diagnose all sickle cell diseases, alpha and beta Thalassemias.
Abstract: A method for determining the likelihood of an ectopic pregnancy and spontaneous miscarriage is described, by measuring the levels of markers, especially hCG and CA-125 which have been found to be characteristic of these conditions. Preferably measuring these biomarker levels at earliest possible presentation of patients with general clinical symptoms and applying cut-off values described determines the likelihood of an ectopic pregnancy and spontaneous miscarriage.
Type:
Application
Filed:
July 2, 2014
Publication date:
August 24, 2017
Applicant:
Map IP Holding Limited
Inventors:
Raymond Kruse Iles, Stephen Andrew Butler