Patents Assigned to MAPI PHARMA LIMITED
  • POLYMORPHS OF DARUNAVIR
    Publication number: 20150148412
    Abstract: The present invention provides new pseudopolymorphic forms of darunavir as well as a novel amorphous form of darunavir, pharmaceutical compositions comprising these compounds, methods for their preparation and use thereof in treating retroviral infections, in particular, HIV infection.
    Type: Application
    Filed: November 24, 2014
    Publication date: May 28, 2015
    Applicant: MAPI PHARMA LIMITED
    Inventor: Ehud MAROM
  • POLYMORPHS OF FEBUXOSTAT
    Publication number: 20130225830
    Abstract: The present invention provides new crystalline forms of febuxostat, pharmaceutical compositions comprising same, methods for their preparation and use thereof in treating hyperuricaemia.
    Type: Application
    Filed: March 17, 2011
    Publication date: August 29, 2013
    Applicant: MAPI PHARMA LIMITED
    Inventors: Ehud Marom, Shai Rubnov
  • POLYMORPHS OF ALOGLIPTIN BENZOATE
    Publication number: 20130059872
    Abstract: The present invention provides new amorphous forms of alogliptin benzoate, pharmaceutical compositions comprising same, methods for their preparation and use thereof in treating conditions mediated by DPP-IV, in particular, type 2 diabetes.
    Type: Application
    Filed: November 22, 2010
    Publication date: March 7, 2013
    Applicant: MAPI PHARMA LIMITED
    Inventors: Ehud Marom, Shai Rubnov
  • PREPARATION OF BENZOFURANS AND USE THEREOF AS SYNTHETIC INTERMEDIATES
    Publication number: 20130046103
    Abstract: The present invention provides several synthetic methods for preparing N-(2-butylbenzofuran-5-yl)-N-(methylsulfonyl)methanesulfonamide, a compound of formula (3), an intermediate in the preparation of Dronedarone. The present invention further provides a process for preparing Dronedarone, comprising the steps of converting 2-butyl-5-bis(methanesulfon)-amidobenzofuran of formula (3) to Dronedarone, wherein the 2-butyl-5-bis(methanesulfon)-amidobenzofuran of formula (3) is prepared by the processes of the present invention.
    Type: Application
    Filed: February 10, 2011
    Publication date: February 21, 2013
    Applicant: MAPI PHARMA LIMITED
    Inventors: Ehud Marom, Michael Mizhiritskii, Shai Rubnov
  • POLYMORPHS OF DARUNAVIR
    Publication number: 20130023570
    Abstract: The present invention provides new pseudopolymorphic forms of darunavir as well as a novel amorphous form of darunavir, pharmaceutical compositions comprising these compounds, methods for their preparation and use thereof in treating retroviral infections, in particular, HIV infection.
    Type: Application
    Filed: July 25, 2012
    Publication date: January 24, 2013
    Applicant: MAPI PHARMA LIMITED
    Inventor: Ehud MAROM
  • PROCESS FOR THE PREPARATION OF DARUNAVIR AND DARUNAVIR INTERMEDIATES
    Publication number: 20120296101
    Abstract: The present invention relates to a process for the preparation of darunavir, a nonpeptide protease inhibitor (PI), useful for the treatment of HIV/AIDS patients harboring multidrug-resistant HIV-1 variants that do not respond to previously existing HAART regimens. The present invention further relates to processes for the stereo-directed preparation of darunavir intermediates, in particular (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-ol and to certain novel intermediates obtained by such processes.
    Type: Application
    Filed: January 24, 2011
    Publication date: November 22, 2012
    Applicant: MAPI PHARMA LIMITED
    Inventors: Michael Mizhiritskii, Ehud Marom
  • INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF TAPENTADOL AND RELATED COMPOUNDS
    Publication number: 20120283463
    Abstract: The present invention discloses processes for the preparation of 3-[(1R,2R)-3-(dimethyl-amino)-1-ethyl-2-methyl-propyl]phenol (Tapentadol), salts thereof and related compounds of formula (A), including stereoisomers and pharmaceutically acceptable salts thereof, and to certain intermediates used in such process.
    Type: Application
    Filed: December 26, 2010
    Publication date: November 8, 2012
    Applicant: MAPI PHARMA LIMITED
    Inventors: Ehud Marom, Michael Mizhiritskii
  • POLYMORPHS OF DARUNAVIR
    Publication number: 20120035142
    Abstract: The present invention provides new pseudopolymorphic forms of darunavir as well as a novel amorphous form of darunavir, pharmaceutical compositions comprising these compounds, methods for their preparation and use thereof in treating retroviral infections, in particular, HIV infection.
    Type: Application
    Filed: December 8, 2009
    Publication date: February 9, 2012
    Applicant: MAPI Pharma Limited
    Inventor: Ehud Marom
  • PROCESS FOR THE PREPARATION OF ALOGLIPTIN
    Publication number: 20120029000
    Abstract: The present invention is based on the discovery of a process for preparing pyrimidin-dione compounds, especially alogliptin and its derivatives, which comprises the reaction of a urea derivative of formula (VIII) with a malonic acid or its derivatives to form intermediates of formulae (VII) or (VII-A), which are subsequently converted to a compound of formula (II) upon introduction of a leaving group X. Compound (II) then reacts with an amine to form compound (I), which is optionally converted to its salts of formula (IV).
    Type: Application
    Filed: March 25, 2010
    Publication date: February 2, 2012
    Applicant: MAPI PHARMA LIMITED
    Inventors: Ehud Marom, Michael Mizhiritskii, Shai Rubnov