Patents Assigned to Marengo Therapeutics, Inc.
  • Method of treating solid cancers with bispecific interleukin-anti-TCRß molecules
    Patent number: 11965025
    Abstract: The disclosure provides antibody molecules that bind to TCR V? regions and multispecific molecules comprising said antibody molecules. Additionally, disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, pharmaceutical compositions comprising aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.
    Type: Grant
    Filed: August 18, 2022
    Date of Patent: April 23, 2024
    Assignee: Marengo Therapeutics, Inc.
    Inventors: Seng-Lai Tan, Brian Edward Vash, Jonathan Hsu, Dilini Charmain Gunasekera, Sangeetha Sagar Palakurthi, Andreas Loew
  • Anti-TCR antibody molecules and uses thereof
    Patent number: 11845797
    Abstract: The disclosure provides antibody molecules that bind to TCR V? regions and multispecific molecules comprising said antibody molecules. Additionally, disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, pharmaceutical compositions comprising aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: December 19, 2023
    Assignee: Marengo Therapeutics, Inc.
    Inventors: Seng-Lai Tan, Brian Edward Vash, Jonathan Hsu, Dilini Charmain Gunasekera, Sangeetha Sagar Palakurthi, Andreas Loew
  • Multispecific antibody molecules comprising lambda and kappa light chains
    Patent number: 11673971
    Abstract: Multispecific, e.g., bispecific, antibody molecules that include a kappa light chain polypeptide and one lambda light chain polypeptide, and methods of making and using the multispecific antibody molecules, are disclosed.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: June 13, 2023
    Assignee: Marengo Therapeutics, Inc.
    Inventors: Andreas Loew, Brian Edward Vash, Stephanie J. Maiocco
  • Multispecific and multifunctional molecules and uses thereof
    Patent number: 11291721
    Abstract: Multispecific molecules that include i) a tumor-targeting moiety; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule; and/or (iv) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.
    Type: Grant
    Filed: March 21, 2017
    Date of Patent: April 5, 2022
    Assignee: Marengo Therapeutics, Inc.
    Inventors: Andreas Loew, Brian Edward Vash