Abstract: The disclosure relates to an improved brachytherapy device, methods of preparation, and uses thereof. More particularly, a flexible bioresorbable brachytherapy device is provided for application on a wound site in a subject. The device includes a sealed radioactive source having opposite first and second sides, wherein the sealed radioactive source includes a radioactive component comprising a plurality of radio-isotope particles dispersed within a carrier. A barrier surrounds the radioactive component providing the sealed radioactive source, wherein the barrier functions as a barrier, when implanted at the wound site, providing the sealed radioactive source for at least six half-lives of the plurality of radio-isotope particles. A bioresorbable shield located on the first side of the sealed radioactive source is configured to shield radioactivity when implanted at the wound site for at least six half-lives of the plurality of radio-isotope particles.

Abstract: A flexible brachytherapy device includes a bioresorbable carrier matrix structure comprising a plurality of radio-isotope particles and having opposite first and second surfaces. The bioresorbable carrier matrix structure degrades, when implanted at a wound site, at a rate such that the bioresorbable carrier matrix structure has a half-life that is longer than a half-life of the plurality of radio-isotope particles. A hydrophilic substrate located adjacent to the first surface of the bioresorbable carrier matrix structure degrades, when implanted at the wound site, at a rate faster than the bioresorbable carrier matrix structure. A hydrogel substrate located adjacent to the second surface of the bioresorbable carrier matrix structure shields radioactivity and degrades at a rate such that the hydrogel substrate has a half-life that is longer than the half-life of the plurality of radio-isotope particles.