Patents Assigned to Maria I. C. Gyongyossy-Issa
  • Publication number: 20170095421
    Abstract: A synthetic platelet substitute that interacts with platelets and the (sub)endothelium, comprising: (a) a carrier molecule comprising lipidic particles with a cross-linked surface mesh, the lipidic particles comprising: an inner lipidic particle of pharmaceutically acceptable particle-forming lipids; hydrophilic polymer chains linked to the surface of the lipidic particle, the hydrophilic polymer chains comprising a crosslinkable end group at free ends thereof; and cross-linker groups linking the end groups of the hydrophilic polymer chains to form the cross-linked surface mesh; and (b) at least one receptor molecule attached to the surface of the carrier molecule. The receptor molecule can be a peptide moiety specific for ligands involved in platelet function.
    Type: Application
    Filed: May 2, 2016
    Publication date: April 6, 2017
    Applicant: Maria I. C. Gyongyossy-Issa
    Inventors: MARIA I.C. GYONGYOSSY-ISSA, Jayachandran N. Kizhakkedathu, Iren Constantinescu, William Campbell, Carlos A. Del Carpio Munoz
  • Publication number: 20170095420
    Abstract: A method for producing a composition of lipidic particles coated with a cross-linked surface mesh, the method comprising the steps of: (i) preparing lipidic particles comprising pharmaceutically acceptable lipids, (ii) binding hydrophilic polymer chains to the surface of the lipidic particles, and (iii) cross-linking the hydrophilic polymer chains to form the cross-linked surface mesh. Pharmaceutical compositions comprising surface modified lipidic particles prepared according to this method are also described. The lipidic particles resist fusion with red blood cells and platelets in vitro, and are amenable to further derivatization by targeting molecules for controlled release of component and contents, thus providing a new generation of drug carrier systems.
    Type: Application
    Filed: May 2, 2016
    Publication date: April 6, 2017
    Applicant: Maria I. C. Gyongyossy-Issa
    Inventors: MARIA I.C. GYONGYOSSY-ISSA, Jayachandran N. Kizhakkedathu, Iren Constantinescu