Abstract: Minimally invasive surgical systems and corresponding methods that can be quickly and accurately calibrated and/or provided in a pre-calibrated manner are disclosed. The systems and method receive an indication designating at least one portion of the surgical site as a safe or a danger zone and display the designated zone(s) on a livestream of the surgical site. The designated zones identify locations where the surgical instrument should avoid (danger zone), or where the surgical instrument is intended to be placed for the surgery or where the one or more surgical instruments can be safely maneuvered (safe zone and dissection zone).