Abstract: Novel compounds and their salts are disclosed having the Formulas: ##STR1## wherein: R.sub.1 is hydrogen, phenyl, 9H-fluoren-9-yl, 10,11-dihydro-5H-dibenzo [a,d]cyclohepten-5-yl, 5H-dibenzo[a,d]cyclohepten-5-yl, 1,2,3,4-tetrahydro-1-naphthyl, 9H-xanthen-9-yl, 9H-thioxanthen-9-yl, 2-chloro-9H-thioxanthen-9-yl, 4H-chromanyl, diphenylmethyl, phenylcycloalkylmethyl wherein the bridgehead methylene may optionally be substituted with a hydroxy group and any of the phenyl or benzo-fused rings may be substituted with one or more R.sub.5 groups wherein R.sub.5 is selected from halogen, trifluoromethyl, lower alkyl, hydroxy or lower alkoxy groups; andR.sub.2 and R.sub.3, which may be the same or different, are hydrogen, lower alkyl, phenylalkyl (C.sub.1 -C.sub.5), wherein the phenyl ring may be substituted with one or more R.sub.5 groups or NR.sub.2 R.sub.

Abstract: A combination of the titled compounds, appropriate salt(s) thereof, and/or the like, is employed for significantly alleviating hypertension and so forth.

Abstract: Novel 1-azabicyclo[2.2.2]octan-3-yl 2-aryl-3-azacyclo-2-hydroxypropionates and their quaternary salts and their use as antimuscarinic agents having antisecretory activity selective for the gastrointestinal tract are disclosed. The compounds have the formula: ##STR1## wherein: X=H, halogen, lower alkyl, lower alkoxy, hydroxy, andR=morpholinyl, thiomorpholinyl, piperidinyl, 1,4-dioxa-8-azaspiro[4.5]decanyl, 4-(2,6-dimethylmorpholinyl), 4-ketopiperidinyl, 4-hydroxypiperidinyl, 4-substituted piperazinyl (wherein the substituent is lower alkyl, hydroxyalkyl, acetoxyalkyl, or acyl).Also disclosed are pharmaceutical compositions for treatment of irritable bowel syndrome and methods for using such compounds.

Abstract: A manual liquid filtration device includes a housing having an open lower end providing access to an internal vacuum chamber, and defining a liquid specimen receiving chamber at its upper end adapted for flow communication with the vacuum chamber. An elastic diaphragm extends across the lower open end of the housing and upwardly along its outer peripheral surface so as to cooperate with air orifices in the housing to define valve means enabling unidirectional air flow from the vacuum chamber. A porous membrane filter element is interposed between the specimen receiving chamber and the vacuum chamber and when dry enables air to pass therethrough from the vacuum chamber upon flexing of the diaphragm into the vacuum chamber. When wetted by water, the filter element maintains vacuum in the vacuum chamber but enables liquid from a liquid specimen to be drawn through the filter element so as to retain solid particulate on the filter element for diagnosis or further reagent washing.

Abstract: 1,3-alkylsubstituted-8-(3,4-,3- or 4-substituted phenyl)xanthines and pharmaceutically acceptable salts of such compounds are disclosed. The 3-substituents are hydrogen, dimethylaminomethyl, or 2,3-dihydroxypropyloxy. The 4-substituents are selected from hydroxy, cyano, --NHCON(R.sub.5).sub.2, --C(.dbd.NH)N(R.sub.5).sub.2, --NH--C(.dbd.NH)N(R.sub.5).sub.2, with each R.sub.5 independently being hydrogen or an alkyl group of one to three carbons and provided that when the 3-substituent is hydrogen the 4-substituent is not hydroxy or hydrogen.The compounds are potent adenosine receptor antagonists having relatively low lipophilicity. The compounds are intended for use as bronchodilators and cardiotonics.

Abstract: A unit in the form of a bubble pack for creating an anaerobic gaseous atmosphere in a bag and for indicating the presence of the anaerobic atmosphere in the bag. One bubble of the pack houses an acid-containing ampoule and also houses tablets which generate hydrogen and carbon dioxide when activated by squeezing the bubble to crush the ampoule and release the acid. Another bubble communicates with the first bubble by way of a tunnel-like bubble and serves as an expansion chamber for the gas and the released acid. Gas flows from the expansion bubble into the bag and enters still another bubble which houses an ampoule containing a redox color indicating liquid. When the latter ampoule is crushed, the liquid moistens an absorbent pad which changes colors as the atmosphere of the bag changes from aerobic to anaerobic.

Abstract: An apparatus and method for spray application of a burn treating agent is disclosed. The apparatus delivers substantially all of the treating agent from a flexible source thereof through a spray nozzle, preferably without bringing the agent into contact with ambient air or contaminants. In a preferred embodiment, silver sulfadiazine cream is sprayed on a burn wound by urging the cream toward an outlet in a collapsible bag in which the cream is disposed by means of pressure applied to the exterior surface of the bag and conveying the cream from the outlet to a sanitary spray nozzle by means of a compressed air operated sanitary pump.

Abstract: A culture collecting swab and a sealed glass ampoule packaged end to end in an envelope and initially are held in an assembled condition by a resiliently yieldable closure member which is carried on the end of the stem of the swab and which includes a cup portion snugly telescoped on one end portion of the ampoule. After a culture has been collected on the tip of the swab, the ampoule is broken open along a score line inside the cup portion of the closure member, the end portion broken off the ampoule being retained in the cup portion. The tip and end of the swab are then inserted into the ampoule through the open end thereof to immerse the tip in a culture-sustaining media and, as an incident to this, a plug portion on the closure member enters and closes the open end of the ampoule.

Abstract: A practice for recovering the contents of filled pharmaceutical capsules wherein the capsules are supported and a cutting blade cuts the supported capsules to allow egress of the capsule contents.

Abstract: Aminoalkylindans of the formula ##STR1## wherein A represents an alkylene group having 2 to 5 carbons in a straight chain, R.sub.1 represents a lower alkyl having 1 to 3 carbons or is a lower alkoxy having 1 to 3 carbons, B represents --CH.sub.2 -- or ##STR2## and R.sub.2 represents phenyl or phenyl-lower alkyl and the phenyl group in such substituents is unsubstituted or is substituted with 1 to 3 lower alkoxy groups, and acid addition salts of the amines.The compounds have hypotensive activity.

Abstract: An anaerobic liquid storage and transport apparatus including a liquid receiver means for receiving and holding an anaerobic liquid, a gas generator container means having a self-contained gas generator for generating at least a reducing gas, conduit means for supplying gas from the gas generator into the liquid receiver means, conduit means for removing gas from the liquid receiver means, and a catalyst which promotes reaction between the reducing gas, when produced by the gas generator, and oxygen in, from and/or around the apparatus.

Abstract: Provided are compounds of the formula ##STR1## wherein R and R.sub.1 are the same or different lower alkyl groups and R.sub.3 is hydrogen or CHO--.

Abstract: Provided are novel 5-alkoxy-2-alkyl-1,2,3,4-tetrahydroisoquinolines of the formula ##STR1## wherein A is CHO--, HOOC--CH.dbd.CH--, or HOOC--CH.sub.2 --CH.sub.2 --, R and R.sub.1 are the same or different lower alkyl groups, and acid addition salts and quaternary ammonium salts thereof.

Abstract: A package for storing, incubating or transporting an anaerobic culture comprising a bag of flexible sheet material of low gas permeability, a self-contained gas generating apparatus in the bag for generating at least a reducing gas, a culture retaining container in the bag, and a catalyst in the bag which promotes reaction between the reducing gas, when produced by the gas generating apparatus, and oxygen in the bag. The bag may also contain a color indicator apparatus which when activated indicates the presence or absence of oxygen in the bag by color change. Hydrogen is the preferred reducing gas which is generated, alone or in conjunction with carbon dioxide.

Abstract: A color indicator apparatus for determining the presence of oxygen which comprises a container which permits flow of gas thereto, an ampoule in the container, said ampoule containing a redox color indicator liquid, and an absorbent material, for the liquid in the ampoule, in the container. Typically the redox color indicator is methylene blue or resazurin. The apparatus is useful for determining if an anaerobic atmosphere exists around a micro-organism culture.

Abstract: Disclosed are 5,6,7 or 8-nuclear substituted benzamido-1,2,3,4-tetrahydroisoquinolines of the formula ##STR1## in which R is a phenyl containing one to three hydroxyl, nitro, halo, lower alkyl or lower alkoxy groups, and R.sub.1 is hydrogen or a lower alkyl. The compounds lower blood pressure in animals.

Abstract: A culture collecting and transporting apparatus comprising a closable container having a collected culture receiving depot therein, means in the container for supplying a culture medium to a culture placed on the depot, and chemical means in the container selectively activated after a culture is placed on the depot, said chemical means when activated supplying gaseous carbon dioxide, and a reducing agent system effective for reducing oxygen, at least in the container space surrounding the collected culture. The reducing agent system may comprise a reducing gas and a catalyst for inducing reaction of the oxygen with the reducing gas. The reducing gas may be hydrogen.

Abstract: A gas generating apparatus, for use in microorganism maintenance during sample transport, storage or incubation, comprising a container having an opening, a gas generating solid material in the container, an ampoule containing a liquid which is reactive with the solid material to produce a gas, said ampoule being openable from outside the container to free the liquid to contact the solid material, and means in the container which prevents liquid from flowing from the container after the ampoule is opened but which permits flow of gas generated in the container out of the container opening. A solid desiccant material may be put in the container to absorb water which may enter the container before the ampoule is opened, thereby preventing degradation or premature reaction of the gas generating solid material.A reducing gas, such as hydrogen, is generated alone or with carbon dioxide. The hydrogen catalytically combines with oxygen to form an anaerobic atmosphere.

Abstract: A gas generating apparatus comprising a container having an opening, a gas generating material in the container, an ampoule containing a liquid which is reactive with the gas generating material to produce a gas, said ampoule being openable from outside the container to free the liquid to contact the gas generating material, and means in the container which prevents liquid from flowing from the container after the ampoule is opened but which permits flow of gas generated in the container out of the container opening.