Patents Assigned to Marligen Biosciences, Inc.
  • Methods of detecting a plurality of sequence specific DNA binding proteins with oligonucleotide detection duplexes
    Patent number: 7771940
    Abstract: Compositions and methods are provided for detecting and measuring DNA-binding proteins. The compositions and methods permit the simultaneous or near-simultaneous detection of multiple DNA-binding proteins in a multiplex or array format, and can be used to generate profiles of DNA binding activity by proteins, specifically, transcription factors. Multiple protein-DNA binding events in a single sample may be detected and quantitated in a high-throughput format.
    Type: Grant
    Filed: October 16, 2006
    Date of Patent: August 10, 2010
    Assignee: Marligen Biosciences, Inc.
    Inventors: Peter A. Clausen, David P. Carlson, James G. Lazar
  • Methods of detecting sequence-specific DNA binding proteins
    Publication number: 20090208927
    Abstract: Compositions and methods are provided for detecting and measuring DNA-binding proteins. The compositions and methods permit the simultaneous or near-simultaneous detection of multiple DNA-binding proteins in a multiplex or array format, and can be used to generate profiles of DNA binding activity by proteins, specifically, transcription factors. Multiple protein-DNA binding events in a single sample may be detected and quantitated in a high-throughput, format.
    Type: Application
    Filed: October 16, 2006
    Publication date: August 20, 2009
    Applicant: Marligen Biosciences, Inc.
    Inventors: Peter A. Clausen, David P. Carlson, James G. Lazar
  • Multiplex method of detecting sequence-specific DNA binding proteins using detection duplexes comprising unmodified nucleic acid sequences as capture tags
    Patent number: 7122317
    Abstract: Compositions and methods are provided for detecting and measuring DNA-binding proteins. The compositions and methods permit the simultaneous or near-simultaneous detection of multiple DNA-binding proteins in a multiplex or array format, and can be used to generate profiles of DNA binding activity by proteins, specifically, transcription factors. Multiple protein-DNA binding events in a single sample may be detected and quantitated in a high-throughput format.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: October 17, 2006
    Assignee: Marligen Biosciences, Inc.
    Inventors: Peter A. Clausen, David P. Carlson, James G. Lazar
  • Detection of protease enzymes
    Publication number: 20060134774
    Abstract: Methods and compositions for the detection of biomolecules, for example, proteases, are provided. The novel compositions, methods, and kits of the present invention have broad applicability in the detection of proteases, and providing enhanced specificity in the detection of proteases. The compositions and methods may be used to measure the activities of multiple proteases simultaneously or in a multiplexed format, particularly in planar and liquid array formats.
    Type: Application
    Filed: November 24, 2003
    Publication date: June 22, 2006
    Applicant: Marligen Biosciences, Inc.
    Inventors: Peter Clausen, James Lazar