Patents Assigned to Marshall University Research Corporation
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Publication number: 20130295198Abstract: Methods for selecting chemotherapeutic agents for treating a cancer are provided that include the steps of providing a cancer cell sample having a population of bulk cancer cells and a population of cancer stem-like cells, culturing a first portion of the cancer cell sample in a hydrodynamic focusing bioreactor under microgravity conditions and for a period of time to selectively enhance the population of cancer stem-like cells and selectively kill the population of bulk cancer cells, contacting the cancer stem-like cells with one or more chemotherapeutic agents, and then selecting the one or more chemotherapeutic agents for treating the cancer if there is an increase in an amount of cytotoxicity. Methods for treating a cancer are also provided in which the identified chemotherapeutic agents are administered to a subject. Further provided are methods for identifying a test compound useful for treating a cancer.Type: ApplicationFiled: March 19, 2013Publication date: November 7, 2013Applicant: Marshall University Research CorporationInventor: Marshall University Research Corporation
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Publication number: 20130183352Abstract: Compositions are provided comprising a nanofiber scaffold that is seeded with one or more relevant cells and has a basketweave configuration that mimics the structure of a tissue, such as a cardiac tissue. Methods for treating damaged cardiac tissue in a subject are also provided and include applying an effective amount of the composition to damaged cardiac tissue. Methods for making nanofiber scaffold compositions are further provided and include electrospinning a biodegradable polymer onto a mandrel to create a mat of electrospun nanofibers, dividing the mat into nanofiber strips; and weaving the strips into a nanofiber scaffold having a basketweave configuration that mimics the structure of a tissue.Type: ApplicationFiled: January 16, 2013Publication date: July 18, 2013Applicant: MARSHALL UNIVERSITY RESEARCH CORPORATIONInventor: Marshall University Research Corporation
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Patent number: 8399649Abstract: Compositions and methods for detecting and controlling the conversion to mucoidy in Pseudomonas aeruginosa are disclosed. The present invention provides for detecting the switch from nonmucoid to mucoid state of P. aeruginosa by measuring mucE expression or MucE protein levels. The interaction between MucE and AlgW controls the switch to mucoidy in wild type P. aeruginosa. Also disclosed is an alginate biosynthesis heterologous expression system for use in screening candidate substances that inhibit conversion to mucoidy.Type: GrantFiled: June 21, 2010Date of Patent: March 19, 2013Assignee: Marshall University Research CorporationInventors: Hongwei D. Yu, Dongru Qiu
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Publication number: 20130040381Abstract: A thermal cycle system and method suitable for mass production of DNA comprising a temperature control body having at least two sectors. Each sector has at least one heater, cooler, or other means for changing temperature. A path traverses the sectors in a cyclical fashion. In use, a piece of tubing or other means for conveying is placed along the path and a reaction mixture is pumped or otherwise moved along the path such that the reaction mixture is repetitively heated or cooled to varying temperatures as the reaction mixture cyclically traverses the sectors. The reaction mixture thereby reacts to form a product. In particular, polymerase chain reaction reactants may continuously be pumped through the tubing to amplify DNA. The temperature control body is preferably a single aluminum cylinder with a grooved channel circling around its exterior surface, and preferably has wedge-shaped or pie-shaped sectors separated by a thermal barrier.Type: ApplicationFiled: September 19, 2012Publication date: February 14, 2013Applicant: Marshall University Research CorporationInventor: Marshall University Research Corporation
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Patent number: 8293471Abstract: A thermal cycle system and method suitable for mass production of DNA comprising a temperature control body having at least two sectors. Each sector has at least one heater, cooler, or other means for changing temperature. A path traverses the sectors in a cyclical fashion. In use, a piece of tubing or other means for conveying is placed along the path and a reaction mixture is pumped or otherwise moved along the path such that the reaction mixture is repetitively heated or cooled to varying temperatures as the reaction mixture cyclically traverses the sectors. The reaction mixture thereby reacts to form a product. In particular, polymerase chain reaction reactants may continuously be pumped through the tubing to amplify DNA. The temperature control body is preferably a single aluminum cylinder with a grooved channel circling around its exterior surface, and preferably has wedge-shaped or pie-shaped sectors separated by a thermal barrier.Type: GrantFiled: January 28, 2005Date of Patent: October 23, 2012Assignee: Marshall University Research CorporationInventors: Derek A. Gregg, Elizabeth E. Murray, Michael L. Norton, Justin T. Swick, Herbert Tesser
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Publication number: 20120139262Abstract: A motion induced electric generator is mounted to a vehicle or conveyance to harness the oscillatory motion generated during travel of the vehicle or conveyance, and may be coupled to at least one device or system, such as an external rail car lighting system, a global positioning device, a diagnostic device, or a combination thereof. Once the motion of the vehicle is harnessed and translated into usable and/or storable energy, the current or voltage is transmitted directly to the units for immediate consumption or for storage in a battery, capacitor, or a combination thereof.Type: ApplicationFiled: October 14, 2011Publication date: June 7, 2012Applicant: MARSHALL UNIVERSITY RESEARCH CORPORATIONInventors: Richard D. Begley, Donald W. Osborne, Anthony B. Szwilski, Frank Adkins
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Patent number: 8180590Abstract: A Railroad Surveying and Monitoring System configured on a mobile platform for surveying, monitoring, and analyzing rail position and superstructure and terrain substructure of railroad tracks (20a,b) or other structures. The system employs two or more High Accuracy Differential Global Positioning System devices (110,112), ground penetrating radar devices (116), terrain conductivity instruments (118), optical cameras (124), and data receivers and processors (126), which in turn process, display, and store the data in a usable database. Precise coordinate data generated from a High Accuracy Global Positioning System provides both location data for subsurface sensors and surface sensors and rail position coordinates to monitor track displacements during track inspection in real time.Type: GrantFiled: October 6, 2004Date of Patent: May 15, 2012Assignee: Marshall University Research CorporationInventors: Anthony B. Szwilski, Richard D. Begley
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Publication number: 20110184157Abstract: Methods for mass producing bacterial alginate, bacterial cultures for producing alginate, and pharmaceutical compositions containing bacterial alginate are contemplated.Type: ApplicationFiled: April 29, 2009Publication date: July 28, 2011Applicant: Marshall University Research CorporationInventors: Hongwei D. YU, Dongru Qiu, F. Heath Damron
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Publication number: 20110008786Abstract: Compositions and methods for detecting and controlling the conversion to mucoidy in Pseudomonas aeruginosa are disclosed. The present invention provides for detecting the switch from nonmucoid to mucoid state of P. aeruginosa by measuring mucE expression or MucE protein levels. The interaction between MucE and AlgW controls the switch to mucoidy in wild type P. aeruginosa. Also disclosed is an alginate biosynthesis heterologous expression system for use in screening candidate substances that inhibit conversion to mucoidy.Type: ApplicationFiled: June 21, 2010Publication date: January 13, 2011Applicant: MARSHALL UNIVERSITY RESEARCH CORPORATIONInventors: Hongwei D. Yu, Dongru Qiu
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Patent number: 7781166Abstract: Compositions and methods for detecting and controlling the conversion to mucoidy in Pseudomonas aeruginosa are disclosed. The present invention provides for detecting the switch from nonmucoid to mucoid state of P. aeruginosa by measuring mucE expression or MucE protein levels. The interaction between MucE and AlgW controls the switch to mucoidy in wild type P. aeruginosa. Also disclosed is an alginate biosynthesis heterologous expression system for use in screening candidate substances that inhibit conversion to mucoidy.Type: GrantFiled: March 29, 2007Date of Patent: August 24, 2010Assignee: Marshall University Research CorporationInventors: Hongwei D. Yu, Dongru Qiu
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Publication number: 20100062435Abstract: The present invention relates to methods for rapidly expanding a stem cell population with or without culture supplements in simulated microgravity conditions. The present invention relates to methods for rapidly increasing the life span of stem cell populations without culture supplements in simulated microgravity conditions. The present invention also relates to methods for increasing the sensitivity of cancer stem cells to chemotherapeutic agents by culturing the cancer stem cells under microgravity conditions and in the presence of omega-3 fatty acids. The methods of the present invention can also be used to proliferate cancer cells by culturing them in the presence of omega-3 fatty acids. The present invention also relates to methods for testing the sensitivity of cancer cells and cancer stem cells to chemotherapeutic agents by culturing the cancer cells and cancer stem cells under microgravity conditions.Type: ApplicationFiled: March 17, 2009Publication date: March 11, 2010Applicant: Marshall University Research CorporationInventors: Pier Paolo Claudio, Jagan V. Valluri
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Publication number: 20090264316Abstract: UV/ozone treatment can be used to alter the hydrophobicity of organosilane coated surfaces. Methods are contemplated for producing micropatterned surfaces by coating a surface with an organosilane to produce an organosilane surface; and exposing the organosilane surface to ultraviolet light in the presence of oxygen, wherein the micropatterned organosilane surface is produced without the use of photoresist. Methods for producing substrate-micropatterned surfaces further are also contemplated. Suitable substrates include nucleotides, proteins, carbohydrates, and cells. The organosilane coated devices of the present invention may be used in, for example, arrays.Type: ApplicationFiled: April 17, 2009Publication date: October 22, 2009Applicant: Marshall University Research CorporationInventors: Eric R. BLOUGH, Hideyo TAKATSUKI, Kevin Matthew RICE, Brian Scott DAY
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Patent number: 6509380Abstract: The present invention relates to methods of controlling iron overload in a patient in need thereof. The present invention particularly relates to methods of treating hemochromatosis and other causes of iron overload.Type: GrantFiled: December 14, 2001Date of Patent: January 21, 2003Assignee: Marshall University Research CorporationInventor: Ernest M. Walker, Jr.
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Patent number: 5958461Abstract: Gelled vaginal pharmaceutical composition containing:a water-soluble bioadhesive polymer, a peroxide source and pH buffer wherein the composition has a pH between about 3.0 and about 6.0; and methods of using same.Type: GrantFiled: June 20, 1997Date of Patent: September 28, 1999Assignee: Marshall University Research CorporationInventor: Bryan Larsen
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Patent number: 5741525Abstract: Gelled vaginal pharmaceutical composition containing:a water-soluble bioadhesive polymer, a peroxide source and pH buffer wherein the composition has a pH between about 3.0 and about 6.0; and methods of using same.Type: GrantFiled: October 24, 1995Date of Patent: April 21, 1998Assignee: Marshall University Research CorporationInventor: Bryan Larsen