Patents Assigned to Martek Biosciences
  • PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    Publication number: 20080044870
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Application
    Filed: July 16, 2007
    Publication date: February 21, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: James Metz, Craig Weaver, William Barclay, James Flatt
  • PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    Publication number: 20080044867
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Application
    Filed: July 12, 2007
    Publication date: February 21, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: James Metz, James Flatt, Jerry Kuner, William Barclay
  • PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    Publication number: 20080044868
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Application
    Filed: July 16, 2007
    Publication date: February 21, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: James Metz, Craig Weaver, William Barclay, James Flatt
  • PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    Publication number: 20080044869
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Application
    Filed: July 16, 2007
    Publication date: February 21, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: James Metz, Craig Weaver, William Barclay, James Flatt
  • PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    Publication number: 20080044871
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Application
    Filed: July 16, 2007
    Publication date: February 21, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: James Metz, Craig Weaver, William Barclay, James Flatt
  • Solventless Extraction Process
    Publication number: 20080044876
    Abstract: The present invention provides a method for extracting lipids from microorganisms without using organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from microorganisms by lysing cells and removing water soluble compound and/or materials by washing the lysed cell mixtures with aqueous washing solutions until a substantially non-emulsified lipid is obtained.
    Type: Application
    Filed: July 24, 2007
    Publication date: February 21, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: Craig Ruecker, Swithin Adu-peasah, Brian Engelhardt, George Veeder
  • Production of DHA in Microalgae in Low pH Medium
    Publication number: 20080044866
    Abstract: Methods for production of highly unsaturated fatty acids by marine microorganisms, including the heterotrophic marine dinoflagellate Crypthecodinium, using low levels of chloride ion are disclosed. Specifically, methods of increasing production of highly unsaturated fatty acids by marine microorganisms while growing in low chloride media by manipulating sodium ion and potassium ion levels. The invention also relates to methods of production of highly unsaturated fatty acids by marine organisms at low pH levels, and includes methods for generation of low pH tolerant strains.
    Type: Application
    Filed: April 20, 2007
    Publication date: February 21, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: Paul Behrens, John Thompson, Kirk Apt, Joseph Pfeifer, James Wynn, James Lippmeier, Jaouad Fichtali, Jon Hansen
  • Method for Production of Arachidonic Acid
    Publication number: 20080044388
    Abstract: The present invention relates to a process for producing arachidonic acid. In one embodiment, Mortierella sect. schmuckeri microorganisms are cultured in fermentation medium, preferably containing a component of a complex nitrogen source. Further disclosed is a food product which includes Mortierella sect. schmuckeri microorganisms or lipid isolated from such microorganisms to enhance the arachidonic acid content of the food product.
    Type: Application
    Filed: July 24, 2007
    Publication date: February 21, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventor: William Barclay
  • PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    Publication number: 20080044874
    Abstract: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
    Type: Application
    Filed: July 23, 2007
    Publication date: February 21, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: Craig Weaver, Ross Zirkle, James Metz
  • PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    Publication number: 20080044872
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Application
    Filed: July 16, 2007
    Publication date: February 21, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: James Metz, Craig Weaver, William Barclay, James Flatt
  • PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    Publication number: 20080038799
    Abstract: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
    Type: Application
    Filed: July 23, 2007
    Publication date: February 14, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: Craig Weaver, Ross Zirkle, James Metz
  • Solventless Extraction Process
    Publication number: 20080038800
    Abstract: The present invention provides a method for extracting lipids from microorganisms without using organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from microorganisms by lysing cells and removing water soluble compound and/or materials by washing the lysed cell mixtures with aqueous washing solutions until a substantially non-emulsified lipid is obtained.
    Type: Application
    Filed: July 24, 2007
    Publication date: February 14, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: Craig Ruecker, Swithwin Adu-peasah, Brian Engelhardt, George Veeder
  • PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    Publication number: 20080038797
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Application
    Filed: July 16, 2007
    Publication date: February 14, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: James Metz, Craig Weaver, William Barclay, James Flatt
  • PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    Publication number: 20080038378
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Application
    Filed: July 12, 2007
    Publication date: February 14, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: James Metz, James Flatt, Jerry Kuner, William Barclay
  • PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    Publication number: 20080038798
    Abstract: Disclosed are the complete polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems from the bacterial microorganisms Shewanella japonica and Shewanella olleyana, and biologically active fragments and homologues thereof. More particularly, this invention relates to nucleic acids encoding such PUFA PKS systems, to proteins and domains thereof that comprise such PUFA PKS systems, to genetically modified organisms (plants and microorganisms) comprising such PUFA PKS systems, and to methods of making and using the PUFA PKS systems disclosed herein. This invention also relates to genetically modified plants and microorganisms and methods to efficiently produce lipids enriched in various polyunsaturated fatty acids (PUFAs) as well as other bioactive molecules by manipulation of a PUFA polyketide synthase (PKS) system.
    Type: Application
    Filed: July 23, 2007
    Publication date: February 14, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: Craig Weaver, Ross Zirkle, James Metz
  • PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    Publication number: 20080038794
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Application
    Filed: July 16, 2007
    Publication date: February 14, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: James Metz, Craig Weaver, William Barclay, James Flatt
  • PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    Publication number: 20080038790
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems isolated from or derived from non-bacterial organisms, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Application
    Filed: March 22, 2007
    Publication date: February 14, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: James Metz, James Flatt, Jerry Kuner, William Barclay
  • PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    Publication number: 20080038795
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Application
    Filed: July 16, 2007
    Publication date: February 14, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: James Metz, Craig Weaver, William Barclay, James Flatt
  • PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    Publication number: 20080040822
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Application
    Filed: July 16, 2007
    Publication date: February 14, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: James Metz, Craig Weaver, William Barclay, James Flatt
  • PUFA POLYKETIDE SYNTHASE SYSTEMS AND USES THEREOF
    Publication number: 20080038379
    Abstract: The invention generally relates to polyunsaturated fatty acid (PUFA) polyketide synthase (PKS) systems, to homologues thereof, to isolated nucleic acid molecules and recombinant nucleic acid molecules encoding biologically active domains of such a PUFA PKS system, to genetically modified organisms comprising PUFA PKS systems, to methods of making and using such systems for the production of bioactive molecules of interest, and to novel methods for identifying new bacterial and non-bacterial microorganisms having such a PUFA PKS system.
    Type: Application
    Filed: July 16, 2007
    Publication date: February 14, 2008
    Applicant: MARTEK BIOSCIENCES CORPORATION
    Inventors: James Metz, Craig Weaver, William Barclay, James Flatt