Abstract: A tamper-resistant packaging arrangement is disclosed which includes a container having a top wall portion defining a container opening, and a closure adapted to be non-removably fitted to the container, and which includes a top wall portion defining a closure opening. The closure is adapted to be fitted to the container and retained threon in a first, unopened position in which the closure opening and the container opening are out of alignment and the container is closed. A coacting arrangement is provided whereby the closure is initially maintained in its first position, and which prevents the closure from being moved back into its first position after it is moved therefrom by relative rotation. The packaging arrangement preferably includes suitable indicia on at least one of the closure and the container to provide a clear visual indication of disposition of the closure in its first, unopened position with respect to the container.