Abstract: Novel and known substituted purine compounds and salts thereof act as adenosine A2a receptor (A2aR) antagonists for cancer immunotherapy, depression, anxiety, multiple sclerosis, NASH, scleroderma, ADHD, Alzheimer's and Parkinsons. Pharmaceutical compositions comprising such compounds, and methods of their use in treating depression are also taught.
Abstract: Purine compounds and salts thereof act as adenosine A2a receptor (A2aR) antagonists for treating cancer immunotherapy, depression, anxiety, multiple sclerosis, NASH, scleroderma, ADHD, Alzheimer's and Parkinson's. Pharmaceutical compositions comprising such compounds, and methods of their use in treating depression are also taught. Form. (I) & (II).
Abstract: A compound of Formula (6): Formula (8): and Formula (10): are prepared and found useful in the treatment and/or prevention of diseases and conditions such as Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, fetal alcohol exposure, autism, schizophrenia, traumatic brain injury, stroke, addictions, Huntington's disease, Fragile X and Rett's syndrome.