Abstract: Interventional immobilization devices used to immobilize a body part and then, during a medical procedure, orient a medical device to treat located tissue within the body part are provided. The devices are designed to immobilize body tissue while preserving, or substantially preserving, the three-dimensional or volumetric integrity of the immobilized tissue. The device enables real time (RT) imaging-guided interventional (IGI) capabilities when the devices are coupled with medical imaging systems, such as magnetic resonance imaging (MRI) systems.