Abstract: A tissue of a multicellular organism is gradually dried during cultivation. After the tissue has been completely dehydrated, water is added to the tissue for its recovery. The tissue of the multicellular organism is submerged in an insect body fluid medium treated with heat, and dried for 48 hours or more.

Abstract: Disclosed herein is a monoclonal antibody of the IgM class which reacts with a glycoprotein antigen having a molecular weight by gel filtration of 1,000,000 or higher, the antigenic determinant to be recognized being a sugar chain with a sialic acid residue at the end thereof. The monoclonal antibody has the following characteristics: (1) a reactivity with human cancers of stomach, large intestine, pancreas, breast, lung, biliary duct, uterus and esophagus; (2) a reactivity with normal human submaxillary gland, proximal renal tubule, bronchial gland, squamous epithelial corneum, pancreatic Langerhans' islands, liver cell membrane and duodenal gland; (3) a reactivity with human intestinal metaplastic gastric mucosa; and (4) a non-reactivity with normal human prostate gland, biliary duct and pancreatic duct.Also provided in the invention is a method for production of monoclonal antibodies.