Patents Assigned to Masarykova Univerzita
-
Patent number: 11744855Abstract: Nanodiamonds having a positive ?-potential of at least 1 mV for use in sequestration of at least one FGF family member in organisms in vivo and in vitro. It has been found that nanodiamonds with a positive ?-potential show an extremely strong and selective binding to FGF family members, thus leading to their usability in the treatment of diseases related to aberrant FGF-FGFR signalling and/or interaction.Type: GrantFiled: March 26, 2019Date of Patent: September 5, 2023Assignees: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I, MASARYKOVA UNIVERZITA, FAKULTNI NEMOCNICE U SV, ANNY V BRNEInventors: Petr Cigler, Lukas Balek, Jan Havlik, Pavel Krejci, Lukas Trantirek, Silvie Trantirkova
-
Patent number: 11746135Abstract: The invention provides an isolated thermostable polypeptide possessing FGF2 activity and having at least 85% sequence identity to SEQ ID NO: 2 (FGF2 wt) or a functional fragment thereof, and comprising at least one amino acid substitution R31L and the use thereof in the cell biology research, regenerative medicine and related medical applications or cosmetics. Further it discloses a culture medium comprising subjected FGF2 suitable for culturing a human pluripotent stem cells involving both human embryonic stem cells and induced pluripotent stem cells.Type: GrantFiled: October 3, 2016Date of Patent: September 5, 2023Assignees: Masarykova Univerzita, Enantis s.r.o.Inventors: Petr Dvorak, Pavel Krejci, Lukas Balek, Livia Eiselleova, Zaneta Konecna, Pavel Dvorak, David Bednar, Jan Brezovsky, Eva Sebestova, Radka Chaloupkova, Veronika Stepankova, Pavel Vanacek, Zbynek Prokop, Jiri Damborsky, Michaela Bosakova
-
Patent number: 11648255Abstract: A new approach to treatment of hematological malignancies. A GAB1 inhibitor for use in a method of treatment of a hematological malignancy is disclosed. The GAB1 inhibitor may be administered alone, or simultaneously or sequentially with a BTK inhibitor to achieve a synergistic effect.Type: GrantFiled: July 6, 2020Date of Patent: May 16, 2023Assignees: MASARYKOVA UNIVERZITA, FAKULTNI NEMOCNICE BRNOInventors: Marek Mraz, Vaclav Seda, Laura Ondrisova
-
Publication number: 20230061133Abstract: The device for treatment of liquids by the help of generation of an electrically powered discharge of low-temperature plasma in liquid environment where is, when the liquid flows, possible to achieve generation of cavitation or super-cavitation which consists of mutually in series connected a pressure regulator and a cavitation tube which is formed by two mutually connected inlet chamber, confusor, working chamber, diffusor and a discharge chamber, where the essence of the invention is that there is in the inlet chamber in its lengthwise axis in direction of liquid flow placed a powered electrode which by its free end reaches into the working chamber and to it is electrically conductive connected a high voltage source whereas the powered electrode is electrically insulated from the body of the cavitation tube and also is in the discharge chamber placed a grounding electrode which is in electric contact with the liquid.Type: ApplicationFiled: December 7, 2020Publication date: March 2, 2023Applicants: VYSOKE UCENI TECHNICKE V BRNE, MASARYKOVA UNIVERZITA, BOTANICKY USTAV AV CR V.V.I.Inventors: Pavel Rudolf, Frantisek Pochyly, Pavel Stahel, Jozef Rahel, Jan Cech, Blahoslav Marsalek
-
Patent number: 11584742Abstract: Compounds represented by the structural formula (1) R1, R2, R3, R4, R5, R6 are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.Type: GrantFiled: April 15, 2019Date of Patent: February 21, 2023Assignee: MASARYKOVA UNIVERZITAInventors: Kamil Paruch, Benoit Carbain, Stepan Havel, Jiri Damborsky, Jan Brezovsky, Lukas Daniel, Alexandra Sisakova, Fedor Nikulenkov, Lumir Krejci
-
Patent number: 11498920Abstract: Novel 4-(1H-imidazol-5-yl)-1H-pyrrolo[2,3-b]pyridine compounds that are useful in the treatment of lymphomas, leukaemias, and solid tumors.Type: GrantFiled: March 26, 2019Date of Patent: November 15, 2022Assignee: MASARYKOVA UNIVERZITAInventors: Vitezslav Bryja, Pavlina Janovska, Michaela Gregorova, Vaclav Nemec, Prashant Khirsariya, Kamil Paruch
-
Patent number: 11453663Abstract: Compounds represented by the structural formula (1) where R1, R2, R3, R4, R5, R6 are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.Type: GrantFiled: April 15, 2019Date of Patent: September 27, 2022Assignee: MASARYKOVA UNIVERZITAInventors: Kamil Paruch, Benoit Carbain, Stepan Havel, Vit Vsiansky, Fedor Nikulenkov, Lumir Krejci
-
Publication number: 20220073507Abstract: Compounds represented by the structural formula (1) where R1, R2, R3, R4, R5, R6 are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.Type: ApplicationFiled: April 15, 2019Publication date: March 10, 2022Applicant: MASARYKOVA UNIVERZITAInventors: Kamil PARUCH, Benoit CARBAIN, Stepan HAVEL, Vit VSIANSKY, Fedor NIKULENKOV, Lumir KREJCI
-
Publication number: 20220002282Abstract: Compounds represented by the structural formula (1) R1, R2, R3, R4, R5, R6 are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.Type: ApplicationFiled: April 15, 2019Publication date: January 6, 2022Applicant: MASARYKOVA UNIVERZITAInventors: Kamil PARUCH, Benoit CARBAIN, Stepan HAVEL, Jiri DAMBORSKY, Jan BREZOVSKY, Lukas DANIEL, Alexandra SISAKOVA, Fedor NIKULENKOV, Lumir KREJCI
-
Publication number: 20220000879Abstract: A new approach to treatment of hematological malignancies. A GAB1 inhibitor for use in a method of treatment of a hematological malignancy is disclosed. The GAB1 inhibitor may be administered alone, or simultaneously or sequentially with a BTK inhibitor to achieve a synergistic effect.Type: ApplicationFiled: July 6, 2020Publication date: January 6, 2022Applicants: Masarykova Univerzita, Fakultni Nemocnice BrnoInventors: Marek Mraz, Vaclav Seda, Laura Ondrisova
-
Publication number: 20210388448Abstract: A method is disclosed for determining prognosis for a patient suffering from follicular lymphoma, that determines the amount of miR-31 in a biological sample taken from the body of the patient, and assigns the patient to a prognostic group based on the determined amount of miR-31, wherein the prognostic groups and the threshold values for assignment to the prognostic groups are obtained by analyzing the amount of miR-31 in biological samples of patients with known prognosis. In the biological sample taken from the patient, the miR-31 expression may be determined along with the expression of an endogenous control, which is a small nuclear RNA or stably expressed miRNA, and, in case of absolute quantification, the expression of synthetic standards of these miRNAs and endogenous controls of known number of molecules are determined. The method allows the assignment of patients to prognostic groups by determining miR-31 expression.Type: ApplicationFiled: October 14, 2019Publication date: December 16, 2021Applicants: MASARYKOVA UNIVERZITA, FAKULTNI NEMOCNICE BRNOInventors: Marek MRAZ, Jan DEVAN, Katerina LITZMANOVIA
-
Publication number: 20210130904Abstract: Method of diagnosing and prognosing colorectal cancer using piRNA-hsa-5937, having the sequence TCCCTGGTGGTCTAGTGGTTAGGATTCGGCA (SEQ ID NO. 1), as a biomarker, in combination with at least one miRNA selected from: (SEQ?ID?NO.?3) miR-23a-3p,?having?the?sequence AUCACAUUGCCAGGGAUUUCC, (SEQ?ID?NO.?4) miR-27a-3p,?having?the?sequence UUCACAGUGGCUAAGUUCCGC, (SEQ?ID?NO.?5) miR-142-5p,?having?the?sequence CAUAAAGUAGAAAGCACUACU. The resulting method uses a body fluid as the input, is non-invasive, has a high sensitivity and specificity even in very early stages of the disease, and is cost-effective.Type: ApplicationFiled: July 13, 2018Publication date: May 6, 2021Applicants: MASARYKOVA UNIVERZITA, MASARYKUV ONKOLOGICKY USTAVInventors: Ondrej SLABY, Petra VYCHYTILOVA, Marek SVOBODA, Milana SACHLOVA
-
Publication number: 20210040086Abstract: Novel 4-(1H-imidazol-5-yl)-1H-pyrrolo[2,3-b]pyridine compounds that are useful in the treatment of lymphomas, leukaemias, and solid tumors.Type: ApplicationFiled: March 26, 2019Publication date: February 11, 2021Applicant: MASARYKOVA UNIVERZITAInventors: Vitezslav BRYJA, Pavlina JANOVSKA, Michaela GREGOROVA, Vaclav NEMEC, Prashant KHIRSARIYA, Kamil PARUCH
-
Publication number: 20210015856Abstract: Nanodiamonds having a positive ?-potential of at least 1 mV for use in sequestration of at least one FGF family member in organisms in vivo and in vitro. It has been found that nanodiamonds with a positive ?-potential show an extremely strong and selective binding to FGF family members, thus leading to their usability in the treatment of diseases related to aberrant FGF-FGFR signalling and/or interaction.Type: ApplicationFiled: March 26, 2019Publication date: January 21, 2021Applicants: USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V.V.I., MASARYKOVA UNIVERZITA, FAKULTNI NEMOCNICE U SV. ANNY V BRNEInventors: Petr CIGLER, Lukas BALEK, Jan HAVLIK, Pavel KREJCI, Lukas TRANTIREK, Silvie TRANTIRKOVA
-
Patent number: 10138554Abstract: A method of plasma treatment of an internal and/or external surface of a hollow electrically non-conductive body. The internal surface of the body and/or its external surface acts a layer of electrical plasma of a surface dielectric barrier discharge generated in a volume of gas by alternating or pulse voltage with an amplitude higher than 100 V from a pair of liquid electrodes formed by an internal electrically conductive liquid situated inside the body and by an external electrically conductive liquid situated outside the body. The electrical plasma is generated above the surface of the electrically conductive liquid, where in the volume of the gas forms a layer of electrical plasma forming a ring copying the shape of the surface of the body wherein the electrical resistance between the liquid electrodes is greater than 10 k?. The invention also is a device for carrying out the aforementioned method.Type: GrantFiled: December 18, 2014Date of Patent: November 27, 2018Assignee: MASARYKOVA UNIVERZITAInventors: David Pavlinak, Dusan Kovacik, Mirko Cernak
-
Patent number: 9969741Abstract: The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3 and R4 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.Type: GrantFiled: June 17, 2015Date of Patent: May 15, 2018Assignee: MASARYKOVA UNIVERZITAInventors: Jiri Damborsky, Fedor Nikulenkov, Alexandra Sisakova, Stepan Havel, Lumir Krejci, Benoit Carbain, Jan Brezovsky, Lukas Daniel, Kamil Paruch
-
Patent number: 9902733Abstract: The invention relates to furo[3,2-b]pyridines substituted at least in position 5 as inhibitors of protein kinases, regulators or modulators, methods of preparation thereof, pharmaceutical compositions containing the compounds, and pharmaceutical use of the compounds and compositions in the treatment of the diseases such as, for example, cancer or neurodegenerative diseases.Type: GrantFiled: April 29, 2015Date of Patent: February 27, 2018Assignee: MASARYKOVA UNIVERZITAInventors: Kamil Paruch, Michaela Petrujova, Vaclav Nemec
-
Patent number: 9782805Abstract: A method for reducing or removing organic and/or inorganic contamination from a vacuum system of imaging and analytical devices, wherein at least a portion of the area of the inner surface of the vacuum space of the vacuum system is provided with a photocatalytic layer, at least a portion of this photocatalytic layer being cooled to a temperature in the range of 0 K to 280 K, whereby the photocatalytic layer is afterwards at least partially irradiated by electromagnetic radiation, which activates a photocatalytic reaction of the photocatalytic layer with the adsorbed gases of the atmosphere of the inner vacuum space of the vacuum system, where this reaction decomposes the contaminants, reducing their concentration and/or the concentration of water in the inner vacuum space of the vacuum system.Type: GrantFiled: January 29, 2015Date of Patent: October 10, 2017Assignees: MASARYKOVA UNIVERZITA, TESCAN ORSAY HOLDING, A.S.Inventors: Pavel Stahel, Mirko Cernak, Zdenek Navratil, Jaroslav Jiruse, Jiri Fiala, Martin Hanicinec
-
Publication number: 20170197966Abstract: The invention provides compounds represented by the structural formula (1): wherein R1, R2, R3 and R4 are as defined in the claims. The compounds are inhibitors of nucleases, and are useful in particular in a method of treatment and/or prevention of proliferative diseases, neurodegenerative diseases, and other genomic instability associated diseases.Type: ApplicationFiled: June 17, 2015Publication date: July 13, 2017Applicant: MASARYKOVA UNIVERZITAInventors: JIRI DAMBORSKY, Fedor NIKULENKOV, Alexandra SISAKOVA, Stepan HAVEL, Lumir KREJCI, Benoit CARBAIN, Jan BREZOVSKY, Lukas DANIEL, Kamil PARUCH
-
Publication number: 20170037052Abstract: The invention relates to furo[3,2-b]pyridines substituted at least in position 5 as inhibitors of protein kinases, regulators or modulators, methods of preparation thereof, pharmaceutical compositions containing the compounds, and pharmaceutical use of the compounds and compositions in the treatment of the diseases such as, for example, cancer or neurodegenerative diseases.Type: ApplicationFiled: April 29, 2015Publication date: February 9, 2017Applicant: MASARYKOVA UNIVERZITAInventors: KAMIL PARUCH, Michaela PETRUJOVA, Vaclav NEMEC