Abstract: The present disclosure provides a respiratory protection device made of soft material comprising folds in zig-zag pattern on the main body and may be adhered to wearer's face by adhesives instead of straps. The respiratory protection device with folds is expandable from flat-fold configuration to open ready-to-use configuration, collapsible from the open ready-to-use configuration to the flat-fold configuration, and flexible to keep adhered to wearer's face when the respiratory protection device is dragged in conjunction with the movement of the wearer's face. The folding structures not only reduce the storage volume but also support the main body of the respiratory protection device to provide large air chamber for breathing comfortably in a completely sealed space. The present disclosure also provides a process of manufacturing the respiratory protection device by folding and fixing barrier layers and applying adhesives on the barrier layers.